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Citations to this article

Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.
S Rossol, … , R Williams, N V Naoumov
S Rossol, … , R Williams, N V Naoumov
Published June 15, 1997
Citation Information: J Clin Invest. 1997;99(12):3025-3033. https://doi.org/10.1172/JCI119498.
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Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B.

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Abstract

Interleukin-12, a cytokine with an important role against intracellular pathogens, promotes Th1 cell development, cellmediated cytotoxicity, and interferon-gamma production. We investigated the immunoregulatory role of IL-12 in 72 chronic hepatitis B virus (HBV) carriers, 33 of whom were monitored longitudinally during interferon-alpha treatment. Serum levels of IL-12 heterodimer, IL-12 p40 subunit, IL-4, and Th1 cytokines were determined by specific ELISAs, and hepatitis B core antigen-specific T cell response by a proliferation assay. Chronic HBV carriers had higher serum levels of IL-12 and IL-12 p40 in comparison with controls (P < 0.01), suggesting that IL-12 production is not impaired. The longitudinal analysis revealed a further substantial increase (> 2.5x baseline level) of bioactive IL-12 and Th1 cytokines in patients who cleared HBV and seroconverted to anti- hepatitis B e, unlike the 23 nonresponders with persistent HBV replication (P < 0.01). The IL-12 peak followed the peak of hepatocytolysis by 9.8+/-2.8 wk and occurred either before or simultaneously with hepatitis B e seroconversion. Hepatitis B core antigen-specific T cell proliferation closely correlated with hepatocytolysis and increased significantly in all patients (8 responders and 15 nonresponders) who developed hepatitis flare, irrespective of the virological outcome. These results provide in vivo evidence that IL-12 may have an important role for viral clearance in chronic HBV infection.

Authors

S Rossol, G Marinos, P Carucci, M V Singer, R Williams, N V Naoumov

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Total citations by year

Year: 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1967 Total
Citations: 2 5 5 5 2 3 3 1 7 10 9 9 4 7 4 4 10 7 15 6 9 7 8 9 5 7 3 1 167
Citation information
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Citations to this article in year 2004 (6)

Title and authors Publication Year
Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy
GJ Webster, S Reignat, D Brown, GS Ogg, L Jones, SL Seneviratne, R Williams, G Dusheiko, A Bertoletti
Journal of virology 2004
Kinetics of soluble tumour necrosis factor (TNF)-alpha receptors and cytokines in the early phase of treatment for chronic hepatitis C: comparison between interferon (IFN)-alpha alone, IFN-alpha plus amantadine or plus ribavirin
F Torre, S Rossol, N Pelli, M Basso, A Delfino, A Picciotto
Clinical & Experimental Immunology 2004
In vitro effects of interferon-alpha subtypes on the Th1/Th2 balance in the peripheral blood mononuclear cells from patients with hepatitis C virus infection
N FUJIOKA, T TANAKA, T ARIYASU, Y YANAI, S YAMAMOTO, H YAMAUCHI, H IKEGAMI, M IKEDA, K ORITA, M KURIMOTO
Biomedical Research 2004
Predictive value of serum interleukin-6 and interleukin-12 in children with chronic hepatitis b infection treated with interferon alpha
M Gora-Gebka, A Liberek, W Szydlowska-Lysiak, W Bako, M Korzon
The Pediatric Infectious Disease Journal 2004
Plasma and Liver Carnitine Levels of Children With Chronic Hepatitis B
MA Selimoğlu, RV Yağci
Journal of Clinical Gastroenterology 2004
Review of cytokine profiles in patients with hepatitis
Qiao-Ling Sun, Wei Ran
World journal of gastroenterology : WJG 2004

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