Kidney biopsies from Pima Indians with type II diabetes were analyzed. Subjects were classified clinically as having early diabetes (n = 10), microalbuminuria (n = 17), normoalbuminuria, despite a duration of diabetes equal to that of the subjects with microalbuminuria (n = 12), or clinical nephropathy (n = 12). Subjects with microalbuminuria exhibited moderate increases in glomerular and mesangial volume when compared with those with early diabetes, but could not be distinguished from subjects who remained normoalbuminuric after an equal duration of diabetes. Subjects with clinical nephropathy exhibited global glomerular sclerosis and more prominent structural abnormalities in nonsclerosed glomeruli. Marked mesangial expansion was accompanied by a further increase in total glomerular volume. Glomerular capillary surface area remained stable, but the glomerular basement membrane thickness was increased and podocyte foot processes were broadened. Broadening of podocyte foot processes was associated with a reduction in the number of podocytes per glomerulus and an increase in the surface area covered by remaining podocytes. These findings suggest that podocyte loss contributes to the progression of diabetic nephropathy.
M E Pagtalunan, P L Miller, S Jumping-Eagle, R G Nelson, B D Myers, H G Rennke, N S Coplon, L Sun, T W Meyer
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Quantitative podocyte parameters predict human native kidney and allograft half-lives
Abhijit S. Naik, Farsad Afshinnia, Diane Cibrik, Jeffrey Hodgin, Fan Wu, Min Zhang, Masao Kikuchi, Larysa Wickman, Milagros Samaniego-Picota, Markus Bitzer, Jocelyn Wiggins, Akinlolu Ojo, Yi Li, Roger Wiggins |
JCI Insight | 2016 |
SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion
Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony J Coyle, David J. Salant, Stephen Berasi, Weining Lu |
JCI Insight | 2016 |
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M Edeling, G Ragi, S Huang, H Pavenstädt, K Susztak |
Nature Reviews Nephrology | 2016 |
Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus
PA Kumar, GI Welsh, G Raghu, RK Menon, MA Saleem, GB Reddy |
Archives of Biochemistry and Biophysics | 2016 |
Diabetes and Kidney Disease: Role of Oxidative Stress
JC Jha, C Banal, BS Chow, ME Cooper, K Jandeleit-Dahm |
Antioxidants & Redox Signaling | 2016 |
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JS Lin, K Susztak |
Current Diabetes Reports | 2016 |
Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats
F Cui, Y Gao, W Zhao, D Zou, Z Zhu, X Wu, N Tian, X Wang, J Liu, Y Tong |
Evidence-Based Complementary and Alternative Medicine | 2016 |
Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway
G Huang, J Lv, T Li, G Huai, X Li, S Xiang, L Wang, Z Qin, J Pang, B Zou, Y Wang |
International journal of molecular medicine | 2016 |
Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1
HW Lee, SQ Khan, S Khaliqdina, MM Altintas, F Grahammer, JL Zhao, KH Koh, NJ Tardi, MH Faridi, T Geraghty, DJ Cimbaluk, K Susztak, LF Moita, D Baltimore, PL Tharaux, TB Huber, M Kretzler, M Bitzer, J Reiser, V Gupta |
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JS Kim, BG Han, SO Choi, SK Cha |
BioMed Research International | 2016 |
Treatment with irbesatan may improve slit diaphragm alterations in rats with adriamycin-induced nephropathy
N Wang, R Wei, P Li, Q Li, , Y Yang, M Huang, R Wang, Z Yin, Y Lv, X Chen |
Journal of Renin-Angiotensin-Aldosterone System | 2016 |
Growth arrest specific 2–like protein 1 expression is upregulated in podocytes through advanced glycation end-products
M Liebisch, T Bondeva, S Franke, S Hause, G Wolf |
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VEGF and the diabetic kidney: More than too much of a good thing
S Majumder, A Advani |
Journal of Diabetes and its Complications | 2016 |
Rethinking glomerular basement membrane thickening in diabetic nephropathy: adaptive or pathogenic?
CB Marshall |
American journal of physiology. Renal physiology | 2016 |
Reactive oxygen species are involved in insulin-dependent regulation of autophagy in primary rat podocytes
I Audzeyenka, D Rogacka, A Piwkowska, M Rychlowski, JB Bierla, E Czarnowska, S Angielski, M Jankowski |
The International Journal of Biochemistry & Cell Biology | 2016 |
mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes
S Eid, S Boutary, K Braysh, R Sabra, C Massaad, A Hamdy, A Rashed, S Moodad, K Block, Y Gorin, HE Abboud, AA Eid |
Antioxidants & Redox Signaling | 2016 |
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L Wickman, JB Hodgin, SQ Wang, F Afshinnia, D Kershaw, RC Wiggins, D Long |
PloS one | 2016 |
Diabetes Induced Changes in Podocyte Morphology and Gene Expression Evaluated Using GFP Transgenic Podocytes
J Xu, S Zheng, PM Kralik, L Krishnan, H Huang, JB Hoying, L Cai, EC Carlson, Y Tan, PN Epstein |
International journal of biological sciences | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach
EN Katsoulieris, GI Drossopoulou, ES Kotsopoulou, DV Vlahakos, EA Lianos, EC Tsilibary, V Sánchez-Margalet |
PloS one | 2016 |
Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients
CP Mariana, PA Ramona, BC Ioana, M Diana, RC Claudia, VD Stefan, KI Maria |
International Urology and Nephrology | 2016 |
Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes
KM Wheelock, M Jaiswal, CL Martin, GD Fufaa, EJ Weil, KV Lemley, B Yee, E Feldman, FC Brosius, WC Knowler, RG Nelson, R Pop-Busui |
Journal of Diabetes and its Complications | 2016 |
Cell cycle re-entry sensitizes podocytes to injury induced death
M Hagen, E Pfister, A Kosel, S Shankland, J Pippin, K Amann, C Daniel |
Cell cycle (Georgetown, Tex.) | 2016 |
A previously unrecognized role of C3a in proteinuric progressive nephropathy
M Morigi, M Locatelli, C Rota, S Buelli, D Corna, P Rizzo, M Abbate, D Conti, L Perico, L Longaretti, A Benigni, C Zoja, G Remuzzi |
Scientific Reports | 2016 |
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GD Fufaa, EJ Weil, KV Lemley, WC Knowler, FC Brosius, B Yee, M Mauer, RG Nelson |
Clinical journal of the American Society of Nephrology : CJASN | 2016 |
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K Sawada, M Toyoda, N Kaneyama, S Shiraiwa, H Moriya, H Miyatake, E Tanaka, N Yamamoto, M Miyauchi, M Kimura, T Wada, M Fukagawa |
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Laboratory Investigation | 2016 |
Podocyte Detachment Is Associated with Renal Prognosis in ANCA-Associated Glomerulonephritis: A Retrospective Cohort Study
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Medicine | 2016 |
Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease
H Trimarchi, R Canzonieri, A Muryan, A Schiel, A Araoz, M Paulero, J Andrews, T Rengel, M Forrester, F Lombi, V Pomeranz, R Iriarte, E Zotta |
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Molecules to Medicine with mTOR
R Fernandes, F Reis |
Molecules to Medicine with mTOR | 2016 |
Rapid Progression of Diabetic Glomerulosclerosis with Crescents to End-stage Renal Disease in Newly Diagnosed Type 2 Diabetes
YS Ko, H Yun, EY Lee, K Jang, JH Yi, SW Han |
Korean Journal of Medicine | 2016 |
Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy
F Liu, M Zong, X Wen, X Li, J Wang, Y Wang, W Jiang, X Li, Z Guo, H Qi |
Scientific Reports | 2016 |
Matrine ameliorates adriamycin-induced nephropathy in rats by enhancing renal function and modulating Th17/Treg balance
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Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes
L Duvnjak, MN Perković, K Blaslov |
Journal of Diabetes and its Complications | 2016 |
Endocrinology
C Napier, SH Pearce |
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Molecular medicine reports | 2016 |
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VG Puelles, LA Cullen-McEwen, GE Taylor, J Li, MD Hughson, PG Kerr, WE Hoy, JF Bertram |
American journal of physiology. Renal physiology | 2016 |
Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes
F Lizotte, B Denhez, A Guay, N Gévry, AM Côté, P Geraldes |
Diabetes | 2016 |