Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Podocyte loss and progressive glomerular injury in type II diabetes.
M E Pagtalunan, … , L Sun, T W Meyer
M E Pagtalunan, … , L Sun, T W Meyer
Published January 15, 1997
Citation Information: J Clin Invest. 1997;99(2):342-348. https://doi.org/10.1172/JCI119163.
View: Text | PDF
Research Article Article has an altmetric score of 6

Podocyte loss and progressive glomerular injury in type II diabetes.

  • Text
  • PDF
Abstract

Kidney biopsies from Pima Indians with type II diabetes were analyzed. Subjects were classified clinically as having early diabetes (n = 10), microalbuminuria (n = 17), normoalbuminuria, despite a duration of diabetes equal to that of the subjects with microalbuminuria (n = 12), or clinical nephropathy (n = 12). Subjects with microalbuminuria exhibited moderate increases in glomerular and mesangial volume when compared with those with early diabetes, but could not be distinguished from subjects who remained normoalbuminuric after an equal duration of diabetes. Subjects with clinical nephropathy exhibited global glomerular sclerosis and more prominent structural abnormalities in nonsclerosed glomeruli. Marked mesangial expansion was accompanied by a further increase in total glomerular volume. Glomerular capillary surface area remained stable, but the glomerular basement membrane thickness was increased and podocyte foot processes were broadened. Broadening of podocyte foot processes was associated with a reduction in the number of podocytes per glomerulus and an increase in the surface area covered by remaining podocytes. These findings suggest that podocyte loss contributes to the progression of diabetic nephropathy.

Authors

M E Pagtalunan, P L Miller, S Jumping-Eagle, R G Nelson, B D Myers, H G Rennke, N S Coplon, L Sun, T W Meyer

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1994 1949 Total
Citations: 7 17 21 28 49 48 39 27 46 38 44 57 47 38 39 38 31 38 31 30 25 17 27 21 10 12 6 6 1 3 1 842
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (38)

Title and authors Publication Year
Quantitative podocyte parameters predict human native kidney and allograft half-lives
Abhijit S. Naik, Farsad Afshinnia, Diane Cibrik, Jeffrey Hodgin, Fan Wu, Min Zhang, Masao Kikuchi, Larysa Wickman, Milagros Samaniego-Picota, Markus Bitzer, Jocelyn Wiggins, Akinlolu Ojo, Yi Li, Roger Wiggins
JCI Insight 2016
SLIT2-ROBO2 signaling pathway inhibits non-muscle myosin IIA activity and destabilizes kidney podocyte adhesion
Xueping Fan, Hongying Yang, Sudhir Kumar, Kathleen Tumelty, Anna Pisarek-Horowitz, Hila Milo Rasouly, Richa Sharma, Stefanie Chan, Edyta Tyminski, Michael Shamashkin, Mostafa Belghasem, Joel Henderson, Anthony J Coyle, David J. Salant, Stephen Berasi, Weining Lu
JCI Insight 2016
Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog
M Edeling, G Ragi, S Huang, H Pavenstädt, K Susztak
Nature Reviews Nephrology 2016
Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus
PA Kumar, GI Welsh, G Raghu, RK Menon, MA Saleem, GB Reddy
Archives of Biochemistry and Biophysics 2016
Diabetes and Kidney Disease: Role of Oxidative Stress
JC Jha, C Banal, BS Chow, ME Cooper, K Jandeleit-Dahm
Antioxidants & Redox Signaling 2016
Podocytes: the Weakest Link in Diabetic Kidney Disease?
JS Lin, K Susztak
Current Diabetes Reports 2016
Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats
F Cui, Y Gao, W Zhao, D Zou, Z Zhu, X Wu, N Tian, X Wang, J Liu, Y Tong
Evidence-Based Complementary and Alternative Medicine 2016
Notoginsenoside R1 ameliorates podocyte injury in rats with diabetic nephropathy by activating the PI3K/Akt signaling pathway
G Huang, J Lv, T Li, G Huai, X Li, S Xiang, L Wang, Z Qin, J Pang, B Zou, Y Wang
International journal of molecular medicine 2016
Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1
HW Lee, SQ Khan, S Khaliqdina, MM Altintas, F Grahammer, JL Zhao, KH Koh, NJ Tardi, MH Faridi, T Geraghty, DJ Cimbaluk, K Susztak, LF Moita, D Baltimore, PL Tharaux, TB Huber, M Kretzler, M Bitzer, J Reiser, V Gupta
The Journal of biological chemistry 2016
Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis
JS Kim, BG Han, SO Choi, SK Cha
BioMed Research International 2016
Treatment with irbesatan may improve slit diaphragm alterations in rats with adriamycin-induced nephropathy
N Wang, R Wei, P Li, Q Li, , Y Yang, M Huang, R Wang, Z Yin, Y Lv, X Chen
Journal of Renin-Angiotensin-Aldosterone System 2016
Growth arrest specific 2–like protein 1 expression is upregulated in podocytes through advanced glycation end-products
M Liebisch, T Bondeva, S Franke, S Hause, G Wolf
Nephrology Dialysis Transplantation 2016
VEGF and the diabetic kidney: More than too much of a good thing
S Majumder, A Advani
Journal of Diabetes and its Complications 2016
Rethinking glomerular basement membrane thickening in diabetic nephropathy: adaptive or pathogenic?
CB Marshall
American journal of physiology. Renal physiology 2016
Reactive oxygen species are involved in insulin-dependent regulation of autophagy in primary rat podocytes
I Audzeyenka, D Rogacka, A Piwkowska, M Rychlowski, JB Bierla, E Czarnowska, S Angielski, M Jankowski
The International Journal of Biochemistry & Cell Biology 2016
mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes
S Eid, S Boutary, K Braysh, R Sabra, C Massaad, A Hamdy, A Rashed, S Moodad, K Block, Y Gorin, HE Abboud, AA Eid
Antioxidants & Redox Signaling 2016
Podocyte Depletion in Thin GBM and Alport Syndrome
L Wickman, JB Hodgin, SQ Wang, F Afshinnia, D Kershaw, RC Wiggins, D Long
PloS one 2016
Diabetes Induced Changes in Podocyte Morphology and Gene Expression Evaluated Using GFP Transgenic Podocytes
J Xu, S Zheng, PM Kralik, L Krishnan, H Huang, JB Hoying, L Cai, EC Carlson, Y Tan, PN Epstein
International journal of biological sciences 2016
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
High Glucose Impairs Insulin Signaling in the Glomerulus: An In Vitro and Ex Vivo Approach
EN Katsoulieris, GI Drossopoulou, ES Kotsopoulou, DV Vlahakos, EA Lianos, EC Tsilibary, V Sánchez-Margalet
PloS one 2016
Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients
CP Mariana, PA Ramona, BC Ioana, M Diana, RC Claudia, VD Stefan, KI Maria
International Urology and Nephrology 2016
Cardiovascular autonomic neuropathy associates with nephropathy lesions in American Indians with type 2 diabetes
KM Wheelock, M Jaiswal, CL Martin, GD Fufaa, EJ Weil, KV Lemley, B Yee, E Feldman, FC Brosius, WC Knowler, RG Nelson, R Pop-Busui
Journal of Diabetes and its Complications 2016
Cell cycle re-entry sensitizes podocytes to injury induced death
M Hagen, E Pfister, A Kosel, S Shankland, J Pippin, K Amann, C Daniel
Cell cycle (Georgetown, Tex.) 2016
A previously unrecognized role of C3a in proteinuric progressive nephropathy
M Morigi, M Locatelli, C Rota, S Buelli, D Corna, P Rizzo, M Abbate, D Conti, L Perico, L Longaretti, A Benigni, C Zoja, G Remuzzi
Scientific Reports 2016
Structural Predictors of Loss of Renal Function in American Indians with Type 2 Diabetes
GD Fufaa, EJ Weil, KV Lemley, WC Knowler, FC Brosius, B Yee, M Mauer, RG Nelson
Clinical journal of the American Society of Nephrology : CJASN 2016
Upregulation of α 3 β 1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy
K Sawada, M Toyoda, N Kaneyama, S Shiraiwa, H Moriya, H Miyatake, E Tanaka, N Yamamoto, M Miyauchi, M Kimura, T Wada, M Fukagawa
Journal of Diabetes Research 2016
DA-1229, a dipeptidyl peptidase IV inhibitor, protects against renal injury by preventing podocyte damage in an animal model of progressive renal injury
JE Lee, JE Kim, MH Lee, HK Song, JY Ghee, YS Kang, HS Min, HW Kim, JJ Cha, JY Han, SY Han, DR Cha
Laboratory Investigation 2016
Podocyte Detachment Is Associated with Renal Prognosis in ANCA-Associated Glomerulonephritis: A Retrospective Cohort Study
R Zou, S Wang, G Liu, F Yu, M Chen, MH Zhao
Medicine 2016
Podocyturia: A Clue for the Rational Use of Amiloride in Alport Renal Disease
H Trimarchi, R Canzonieri, A Muryan, A Schiel, A Araoz, M Paulero, J Andrews, T Rengel, M Forrester, F Lombi, V Pomeranz, R Iriarte, E Zotta
Case Reports in Nephrology 2016
Molecules to Medicine with mTOR
R Fernandes, F Reis
Molecules to Medicine with mTOR 2016
Rapid Progression of Diabetic Glomerulosclerosis with Crescents to End-stage Renal Disease in Newly Diagnosed Type 2 Diabetes
YS Ko, H Yun, EY Lee, K Jang, JH Yi, SW Han
Korean Journal of Medicine 2016
Silencing of Histone Deacetylase 9 Expression in Podocytes Attenuates Kidney Injury in Diabetic Nephropathy
F Liu, M Zong, X Wen, X Li, J Wang, Y Wang, W Jiang, X Li, Z Guo, H Qi
Scientific Reports 2016
Matrine ameliorates adriamycin-induced nephropathy in rats by enhancing renal function and modulating Th17/Treg balance
Y Xu, H Lin, W Zheng, X Ye, L Yu, J Zhuang, Q Yang, D Wang
European Journal of Pharmacology 2016
Dipeptidyl peptidase-4 activity is associated with urine albumin excretion in type 1 diabetes
L Duvnjak, MN Perković, K Blaslov
Journal of Diabetes and its Complications 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Astragaloside IV prevents high glucose-induced podocyte apoptosis via downregulation of TRPC6
XM Yao, YJ Liu, YM Wang, H Wang, BB Zhu, YP Liang, WG Yao, H Yu, NS Wang, XM Zhang, W Peng
Molecular medicine reports 2016
Human podocyte depletion in association with older age and hypertension
VG Puelles, LA Cullen-McEwen, GE Taylor, J Li, MD Hughson, PG Kerr, WE Hoy, JF Bertram
American journal of physiology. Renal physiology 2016
Persistent Insulin Resistance in Podocytes Caused by Epigenetic Changes of SHP-1 in Diabetes
F Lizotte, B Denhez, A Guay, N Gévry, AM Côté, P Geraldes
Diabetes 2016

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 4 patents
200 readers on Mendeley
See more details