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Citations to this article

Podocyte loss and progressive glomerular injury in type II diabetes.
M E Pagtalunan, … , L Sun, T W Meyer
M E Pagtalunan, … , L Sun, T W Meyer
Published January 15, 1997
Citation Information: J Clin Invest. 1997;99(2):342-348. https://doi.org/10.1172/JCI119163.
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Research Article Article has an altmetric score of 6

Podocyte loss and progressive glomerular injury in type II diabetes.

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Abstract

Kidney biopsies from Pima Indians with type II diabetes were analyzed. Subjects were classified clinically as having early diabetes (n = 10), microalbuminuria (n = 17), normoalbuminuria, despite a duration of diabetes equal to that of the subjects with microalbuminuria (n = 12), or clinical nephropathy (n = 12). Subjects with microalbuminuria exhibited moderate increases in glomerular and mesangial volume when compared with those with early diabetes, but could not be distinguished from subjects who remained normoalbuminuric after an equal duration of diabetes. Subjects with clinical nephropathy exhibited global glomerular sclerosis and more prominent structural abnormalities in nonsclerosed glomeruli. Marked mesangial expansion was accompanied by a further increase in total glomerular volume. Glomerular capillary surface area remained stable, but the glomerular basement membrane thickness was increased and podocyte foot processes were broadened. Broadening of podocyte foot processes was associated with a reduction in the number of podocytes per glomerulus and an increase in the surface area covered by remaining podocytes. These findings suggest that podocyte loss contributes to the progression of diabetic nephropathy.

Authors

M E Pagtalunan, P L Miller, S Jumping-Eagle, R G Nelson, B D Myers, H G Rennke, N S Coplon, L Sun, T W Meyer

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1994 1949 Total
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Citations to this article in year 2011 (39)

Title and authors Publication Year
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Ken Inoki, Hiroyuki Mori, Junying Wang, Tsukasa Suzuki, SungKi Hong, Sei Yoshida, Simone Blattner, Tsuneo Ikenoue, Markus Ruegg, Michael Hall, David J. Kwiatkowski, Maria-Pia Rastaldi, Tobias Huber, Matthias Kretzler, Larry Holzman, Roger Wiggins, Kun-liang Guan
Journal of Clinical Investigation 2011
Wnt/β-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival*
H Kato, A Gruenwald, JH Suh, JH Miner, L Barisoni-Thomas, MM Taketo, C Faul, SE Millar, LB Holzman, K Susztak
The Journal of biological chemistry 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Comprehensive Physiology
R Terjung
Comprehensive Physiology 2011
Alteration of forkhead box o (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
PY Chuang, Y Dai, R Liu, H He, M Kretzler, B Jim, CD Cohen, JC He
PloS one 2011
Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice
SM Ka, YC Yeh, XR Huang, TK Chao, YJ Hung, CP Yu, TJ Lin, CC Wu, HY Lan, A Chen
Diabetologia 2011
Diminished Met Signaling in Podocytes Contributes to the Development of Podocytopenia in Transplant Glomerulopathy
PA Agustian, M Schiffer, W Gwinner, I Schäfer, K Theophile, F Modde, CL Bockmeyer, J Traeder, U Lehmann, A Grosshennig, HH Kreipe, V Bröcker, JU Becker
The American Journal of Pathology 2011
The Renin Inhibitor Aliskiren Attenuates High-Glucose Induced Extracellular Matrix Synthesis and Prevents Apoptosis in Cultured Podocytes
LM Phillips, Y Wang, T Dai, DL Feldman, J LaPage, SG Adler
Nephron Experimental Nephrology 2011
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes
AS Awad, MD Rouse, K Khutsishvili, L Huang, WK Bolton, KR Lynch, MD Okusa
Kidney International 2011
Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in DOCA-salt hypertensive mice
NE Rhaleb, S Pokharel, U Sharma, OA Carretero
Journal of Hypertension 2011
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JM López-Novoa, AB Rodríguez-Peña, A Ortiz, C Martínez-Salgado, FJ Hernández
Journal of Translational Medicine 2011
Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease
GY Chang, AS Park, K Susztak
Kidney International 2011
Role of smooth muscle protein SM22α in glomerular epithelial cell injury
CB Marshall, RD Krofft, MJ Blonski, J Kowalewska, CM Logar, JW Pippin, F Kim, R Feil, CE Alpers, SJ Shankland
AJP Renal Physiology 2011
Podocytopathy in diabetes: a metabolic and endocrine disorder
A Diez-Sampedro, O Lenz, A Fornoni
American journal of kidney diseases : the official journal of the National Kidney Foundation 2011
TRPC6 Enhances Angiotensin II-induced Albuminuria
J Eckel, PJ Lavin, EA Finch, N Mukerji, J Burch, R Gbadegesin, G Wu, B Bowling, A Byrd, G Hall, M Sparks, ZS Zhang, A Homstad, L Barisoni, L Birbaumer, P Rosenberg, MP Winn
Journal of the American Society of Nephrology : JASN 2011
Role of oxidized low density lipoproteins and free fatty acids in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2 diabetes
R Nosadini, G Tonolo
Nutrition, Metabolism and Cardiovascular Diseases 2011
An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
SG Sayyed, M Ryu, OP Kulkarni, H Schmid, J Lichtnekert, S Grüner, L Green, P Mattei, G Hartmann, HJ Anders
Kidney International 2011
Podocyte Detachment in Type 2 Diabetic Nephropathy
EJ Weil, KV Lemley, B Yee, T Lovato, M Richardson, BD Myers, RG Nelson
American Journal of Nephrology 2011
Using Stereologic Techniques for Podocyte Counting in the Mouse: Shifting the Paradigm
SB Nicholas, JM Basgen, S Sinha
American Journal of Nephrology 2011
Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes
EY Kim, SE Dryer
Journal of Cellular Physiology 2011
Dendrin Location in Podocytes Is Associated with Disease Progression in Animal and Human Glomerulopathy
K Asanuma, M Akiba-Takagi, F Kodama, R Asao, Y Nagai, A Lydia, H Fukuda, E Tanaka, T Shibata, H Takahara, T Hidaka, E Asanuma, E Kominami, T Ueno, Y Tomino
American Journal of Nephrology 2011
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease
DS Jung, SH Lee, SJ Kwak, JJ Li, DH Kim, BY Nam, HY Kang, TI Chang, JT Park, SH Han, TH Yoo, SW Kang
Nephrology Dialysis Transplantation 2011
Podocyte research in rheumatic diseases
H Kajiyama
Japanese Journal of Clinical Immunology 2011
The role of metabolic and haemodynamic factors in podocyte injury in diabetes
N Stieger, K Worthmann, M Schiffer
Diabetes/Metabolism Research and Reviews 2011
Carnosine Prevents Apoptosis of Glomerular Cells and Podocyte Loss in STZ Diabetic Rats
E Riedl, F Pfister, M Braunagel, P Brinkkötter, P Sternik, M Deinzer, SJ Bakker, RH Henning, J Born, BK Krämer, G Navis, HP Hammes, B Yard, H Koeppel
Cellular Physiology and Biochemistry 2011
Urinary Excretion of Nephrin in Patients with Severe Preeclampsia
GH Son, JH Kim, JH Hwang, YH Kim, YW Park, JY Kwon
Hypertension in Pregnancy 2011
The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy
M Tunçdemir, M Öztürk
Acta Histochemica 2011
Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians
HA Chakkera, RL Hanson, S Kobes, MP Millis, RG Nelson, WC Knowler, JK Distefano
Molecular Genetics and Metabolism 2011
Bone Marrow–Derived Progenitor Cells Do Not Contribute to Podocyte Turnover in the Puromycin Aminoglycoside and Renal Ablation Models in Rats
C Meyer-Schwesinger, C Lange, V Bröcker, PA Agustian, PA Agustian, U Lehmann, A Raabe, M Brinkmeyer, E Kobayashi, M Schiffer, G Büsche, HH Kreipe, F Thaiss, JU Becker
The American Journal of Pathology 2011
Microalbuminuria: causes and implications
A Singh, SC Satchell
Pediatric nephrology (Berlin, Germany) 2011
Renal Podocyte Apoptosis in Zucker Diabetic Fatty Rats: Involvement of Methylglyoxal-Induced Oxidative DNA Damage
J Kim, E Sohn, CS Kim, JS Kim
Journal of Comparative Pathology 2011
Urinary Excretion of Nephrin in Patients with Severe Preeclampsia: Urinary Nephrin in Preeclampsia
GH Son, JH Kim, JH Hwang, YH Kim, YW Park, JY Kwon
Hypertension in Pregnancy 2011
Progression is caused by angiotensin II-dependent persistent podocyte loss from destabilized glomeruli
A Fukuda, LT Wickman, M Venkatareddy, Y Sato, M Chowdhury, SQ Wang, K Shedden, R Dysko, JE Wiggins, RC Wiggins
Kidney International 2011
The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy
PA Kumar, FC 3rd, RK Menon
Current diabetes reviews 2011
Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death
AM Berhane, EJ Weil, WC Knowler, RG Nelson, RL Hanson
Clinical journal of the American Society of Nephrology : CJASN 2011
Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes
KN Campbell, L Raij, P Mundel
Current diabetes reviews 2011
Alteration of Forkhead Box O (Foxo4) Acetylation Mediates Apoptosis of Podocytes in Diabetes Mellitus
PY Chuang, Y Dai, R Liu, H He, M Kretzler, B Jim, CD Cohen, JC He, SE Dryer
PloS one 2011
Role of smooth muscle protein SM22α in glomerular epithelial cell injury
CB Marshall, RD Krofft, MJ Blonski, J Kowalewska, CM Logar, JW Pippin, F Kim, R Feil, CE Alpers, SJ Shankland
American journal of physiology. Renal physiology 2011
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter
S Sekiguchi, A Suzuki, S Asano, K Nishiwaki-Yasuda, M Shibata, S Nagao, N Yamamoto, M Matsuyama, Y Sato, K Yan, E Yaoita, M Itoh
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