Kidney biopsies from Pima Indians with type II diabetes were analyzed. Subjects were classified clinically as having early diabetes (n = 10), microalbuminuria (n = 17), normoalbuminuria, despite a duration of diabetes equal to that of the subjects with microalbuminuria (n = 12), or clinical nephropathy (n = 12). Subjects with microalbuminuria exhibited moderate increases in glomerular and mesangial volume when compared with those with early diabetes, but could not be distinguished from subjects who remained normoalbuminuric after an equal duration of diabetes. Subjects with clinical nephropathy exhibited global glomerular sclerosis and more prominent structural abnormalities in nonsclerosed glomeruli. Marked mesangial expansion was accompanied by a further increase in total glomerular volume. Glomerular capillary surface area remained stable, but the glomerular basement membrane thickness was increased and podocyte foot processes were broadened. Broadening of podocyte foot processes was associated with a reduction in the number of podocytes per glomerulus and an increase in the surface area covered by remaining podocytes. These findings suggest that podocyte loss contributes to the progression of diabetic nephropathy.
M E Pagtalunan, P L Miller, S Jumping-Eagle, R G Nelson, B D Myers, H G Rennke, N S Coplon, L Sun, T W Meyer
Title and authors | Publication | Year |
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mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice
Ken Inoki, Hiroyuki Mori, Junying Wang, Tsukasa Suzuki, SungKi Hong, Sei Yoshida, Simone Blattner, Tsuneo Ikenoue, Markus Ruegg, Michael Hall, David J. Kwiatkowski, Maria-Pia Rastaldi, Tobias Huber, Matthias Kretzler, Larry Holzman, Roger Wiggins, Kun-liang Guan |
Journal of Clinical Investigation | 2011 |
Wnt/β-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival*
H Kato, A Gruenwald, JH Suh, JH Miner, L Barisoni-Thomas, MM Taketo, C Faul, SE Millar, LB Holzman, K Susztak |
The Journal of biological chemistry | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
Alteration of forkhead box o (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus
PY Chuang, Y Dai, R Liu, H He, M Kretzler, B Jim, CD Cohen, JC He |
PloS one | 2011 |
Kidney-targeting Smad7 gene transfer inhibits renal TGF-β/MAD homologue (SMAD) and nuclear factor κB (NF-κB) signalling pathways, and improves diabetic nephropathy in mice
SM Ka, YC Yeh, XR Huang, TK Chao, YJ Hung, CP Yu, TJ Lin, CC Wu, HY Lan, A Chen |
Diabetologia | 2011 |
Diminished Met Signaling in Podocytes Contributes to the Development of Podocytopenia in Transplant Glomerulopathy
PA Agustian, M Schiffer, W Gwinner, I Schäfer, K Theophile, F Modde, CL Bockmeyer, J Traeder, U Lehmann, A Grosshennig, HH Kreipe, V Bröcker, JU Becker |
The American Journal of Pathology | 2011 |
The Renin Inhibitor Aliskiren Attenuates High-Glucose Induced Extracellular Matrix Synthesis and Prevents Apoptosis in Cultured Podocytes
LM Phillips, Y Wang, T Dai, DL Feldman, J LaPage, SG Adler |
Nephron Experimental Nephrology | 2011 |
Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes
AS Awad, MD Rouse, K Khutsishvili, L Huang, WK Bolton, KR Lynch, MD Okusa |
Kidney International | 2011 |
Renal protective effects of N-acetyl-Ser-Asp-Lys-Pro in DOCA-salt hypertensive mice
NE Rhaleb, S Pokharel, U Sharma, OA Carretero |
Journal of Hypertension | 2011 |
Etiopathology of chronic tubular, glomerular and renovascular nephropathies: clinical implications
JM López-Novoa, AB Rodríguez-Peña, A Ortiz, C Martínez-Salgado, FJ Hernández |
Journal of Translational Medicine | 2011 |
Tracing the footsteps of glomerular insulin signaling in diabetic kidney disease
GY Chang, AS Park, K Susztak |
Kidney International | 2011 |
Role of smooth muscle protein SM22α in glomerular epithelial cell injury
CB Marshall, RD Krofft, MJ Blonski, J Kowalewska, CM Logar, JW Pippin, F Kim, R Feil, CE Alpers, SJ Shankland |
AJP Renal Physiology | 2011 |
Podocytopathy in diabetes: a metabolic and endocrine disorder
A Diez-Sampedro, O Lenz, A Fornoni |
American journal of kidney diseases : the official journal of the National Kidney Foundation | 2011 |
TRPC6 Enhances Angiotensin II-induced Albuminuria
J Eckel, PJ Lavin, EA Finch, N Mukerji, J Burch, R Gbadegesin, G Wu, B Bowling, A Byrd, G Hall, M Sparks, ZS Zhang, A Homstad, L Barisoni, L Birbaumer, P Rosenberg, MP Winn |
Journal of the American Society of Nephrology : JASN | 2011 |
Role of oxidized low density lipoproteins and free fatty acids in the pathogenesis of glomerulopathy and tubulointerstitial lesions in type 2 diabetes
R Nosadini, G Tonolo |
Nutrition, Metabolism and Cardiovascular Diseases | 2011 |
An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
SG Sayyed, M Ryu, OP Kulkarni, H Schmid, J Lichtnekert, S Grüner, L Green, P Mattei, G Hartmann, HJ Anders |
Kidney International | 2011 |
Podocyte Detachment in Type 2 Diabetic Nephropathy
EJ Weil, KV Lemley, B Yee, T Lovato, M Richardson, BD Myers, RG Nelson |
American Journal of Nephrology | 2011 |
Using Stereologic Techniques for Podocyte Counting in the Mouse: Shifting the Paradigm
SB Nicholas, JM Basgen, S Sinha |
American Journal of Nephrology | 2011 |
Effects of insulin and high glucose on mobilization of slo1 BKCa channels in podocytes
EY Kim, SE Dryer |
Journal of Cellular Physiology | 2011 |
Dendrin Location in Podocytes Is Associated with Disease Progression in Animal and Human Glomerulopathy
K Asanuma, M Akiba-Takagi, F Kodama, R Asao, Y Nagai, A Lydia, H Fukuda, E Tanaka, T Shibata, H Takahara, T Hidaka, E Asanuma, E Kominami, T Ueno, Y Tomino |
American Journal of Nephrology | 2011 |
Apoptosis occurs differentially according to glomerular size in diabetic kidney disease
DS Jung, SH Lee, SJ Kwak, JJ Li, DH Kim, BY Nam, HY Kang, TI Chang, JT Park, SH Han, TH Yoo, SW Kang |
Nephrology Dialysis Transplantation | 2011 |
Podocyte research in rheumatic diseases
H Kajiyama |
Japanese Journal of Clinical Immunology | 2011 |
The role of metabolic and haemodynamic factors in podocyte injury in diabetes
N Stieger, K Worthmann, M Schiffer |
Diabetes/Metabolism Research and Reviews | 2011 |
Carnosine Prevents Apoptosis of Glomerular Cells and Podocyte Loss in STZ Diabetic Rats
E Riedl, F Pfister, M Braunagel, P Brinkkötter, P Sternik, M Deinzer, SJ Bakker, RH Henning, J Born, BK Krämer, G Navis, HP Hammes, B Yard, H Koeppel |
Cellular Physiology and Biochemistry | 2011 |
Urinary Excretion of Nephrin in Patients with Severe Preeclampsia
GH Son, JH Kim, JH Hwang, YH Kim, YW Park, JY Kwon |
Hypertension in Pregnancy | 2011 |
The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy
M Tunçdemir, M Öztürk |
Acta Histochemica | 2011 |
Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians
HA Chakkera, RL Hanson, S Kobes, MP Millis, RG Nelson, WC Knowler, JK Distefano |
Molecular Genetics and Metabolism | 2011 |
Bone Marrow–Derived Progenitor Cells Do Not Contribute to Podocyte Turnover in the Puromycin Aminoglycoside and Renal Ablation Models in Rats
C Meyer-Schwesinger, C Lange, V Bröcker, PA Agustian, PA Agustian, U Lehmann, A Raabe, M Brinkmeyer, E Kobayashi, M Schiffer, G Büsche, HH Kreipe, F Thaiss, JU Becker |
The American Journal of Pathology | 2011 |
Microalbuminuria: causes and implications
A Singh, SC Satchell |
Pediatric nephrology (Berlin, Germany) | 2011 |
Renal Podocyte Apoptosis in Zucker Diabetic Fatty Rats: Involvement of Methylglyoxal-Induced Oxidative DNA Damage
J Kim, E Sohn, CS Kim, JS Kim |
Journal of Comparative Pathology | 2011 |
Urinary Excretion of Nephrin in Patients with Severe Preeclampsia: Urinary Nephrin in Preeclampsia
GH Son, JH Kim, JH Hwang, YH Kim, YW Park, JY Kwon |
Hypertension in Pregnancy | 2011 |
Progression is caused by angiotensin II-dependent persistent podocyte loss from destabilized glomeruli
A Fukuda, LT Wickman, M Venkatareddy, Y Sato, M Chowdhury, SQ Wang, K Shedden, R Dysko, JE Wiggins, RC Wiggins |
Kidney International | 2011 |
The glomerular podocyte as a target of growth hormone action: implications for the pathogenesis of diabetic nephropathy
PA Kumar, FC 3rd, RK Menon |
Current diabetes reviews | 2011 |
Albuminuria and estimated glomerular filtration rate as predictors of diabetic end-stage renal disease and death
AM Berhane, EJ Weil, WC Knowler, RG Nelson, RL Hanson |
Clinical journal of the American Society of Nephrology : CJASN | 2011 |
Role of angiotensin II in the development of nephropathy and podocytopathy of diabetes
KN Campbell, L Raij, P Mundel |
Current diabetes reviews | 2011 |
Alteration of Forkhead Box O (Foxo4) Acetylation Mediates Apoptosis of Podocytes in Diabetes Mellitus
PY Chuang, Y Dai, R Liu, H He, M Kretzler, B Jim, CD Cohen, JC He, SE Dryer |
PloS one | 2011 |
Role of smooth muscle protein SM22α in glomerular epithelial cell injury
CB Marshall, RD Krofft, MJ Blonski, J Kowalewska, CM Logar, JW Pippin, F Kim, R Feil, CE Alpers, SJ Shankland |
American journal of physiology. Renal physiology | 2011 |
Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter
S Sekiguchi, A Suzuki, S Asano, K Nishiwaki-Yasuda, M Shibata, S Nagao, N Yamamoto, M Matsuyama, Y Sato, K Yan, E Yaoita, M Itoh |
American journal of physiology. Renal physiology | 2011 |