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Citations to this article

Podocyte loss and progressive glomerular injury in type II diabetes.
M E Pagtalunan, … , L Sun, T W Meyer
M E Pagtalunan, … , L Sun, T W Meyer
Published January 15, 1997
Citation Information: J Clin Invest. 1997;99(2):342-348. https://doi.org/10.1172/JCI119163.
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Research Article Article has an altmetric score of 6

Podocyte loss and progressive glomerular injury in type II diabetes.

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Abstract

Kidney biopsies from Pima Indians with type II diabetes were analyzed. Subjects were classified clinically as having early diabetes (n = 10), microalbuminuria (n = 17), normoalbuminuria, despite a duration of diabetes equal to that of the subjects with microalbuminuria (n = 12), or clinical nephropathy (n = 12). Subjects with microalbuminuria exhibited moderate increases in glomerular and mesangial volume when compared with those with early diabetes, but could not be distinguished from subjects who remained normoalbuminuric after an equal duration of diabetes. Subjects with clinical nephropathy exhibited global glomerular sclerosis and more prominent structural abnormalities in nonsclerosed glomeruli. Marked mesangial expansion was accompanied by a further increase in total glomerular volume. Glomerular capillary surface area remained stable, but the glomerular basement membrane thickness was increased and podocyte foot processes were broadened. Broadening of podocyte foot processes was associated with a reduction in the number of podocytes per glomerulus and an increase in the surface area covered by remaining podocytes. These findings suggest that podocyte loss contributes to the progression of diabetic nephropathy.

Authors

M E Pagtalunan, P L Miller, S Jumping-Eagle, R G Nelson, B D Myers, H G Rennke, N S Coplon, L Sun, T W Meyer

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1994 1949 Total
Citations: 7 17 21 28 49 48 39 27 46 38 44 57 47 38 39 38 31 38 31 30 25 17 27 21 10 12 6 6 1 3 1 842
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Citations to this article in year 2008 (38)

Title and authors Publication Year
Adipokines and Albuminuria: A Direct Communication Between Adiponectin and Podocytes
Kumar Sharma, M.D.1,2 Satish RamachandraRao, Ph.D.1,2 Gang Qiu, M.S.1, Hitomi Kataoka Usui, M.D., Ph.D1,3 Yanqing Zhu, M.D.1, Stephen R. Dunn, B.S.1 , Raogo Ouedraogo, Ph.D. 4, Kelly Hough, B.S.4, Peter McCue, M.D.5, Lawrence Chan, M.D.6, Bonita Falkner, M.D.7, Barry J. Goldstein, M.D., Ph.D.4
Journal of Clinical Investigation 2008
Recent Progress in the Pathogenesis of Nephrotic Proteinuria
V Tesař, T Zima
Critical Reviews in Clinical Laboratory Sciences 2008
What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?
SC Satchell, JE Tooke
Diabetologia 2008
New Insights into the Mechanisms of Fibrosis and Sclerosis in Diabetic Nephropathy
FC Brosius
Reviews in Endocrine and Metabolic Disorders 2008
NOX enzymes and diabetic complications
T Kakehi, C Yabe-Nishimura
Seminars in Immunopathology 2008
Role of MKK3–p38 MAPK signalling in the development of type 2 diabetes and renal injury in obese db/db mice
AK Lim, DJ Nikolic-Paterson, FY Ma, E Ozols, MC Thomas, RA Flavell, RJ Davis, GH Tesch
Diabetologia 2008
Podocyte injury induced by albumin overload in vivo and in vitro: involvement of TGF-beta and p38 MAPK
S Yoshida, M Nagase, S Shibata, T Fujita
Nephron Experimental Nephrology 2008
Selective loss of podoplanin protein expression accompanies proteinuria and precedes alterations in podocyte morphology in a spontaneous proteinuric rat model
K Koop, M Eikmans, M Wehland, H Baelde, D Ijpelaar, R Kreutz, H Kawachi, D Kerjaschki, E Heer, JA Bruijn
The American Journal of Pathology 2008
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T Hidaka, Y Suzuki, M Yamashita, T Shibata, Y Tanaka, S Horikoshi, Y Tomino
The American Journal of Pathology 2008
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M Nagase, T Fujita
Clinical and Experimental Nephrology 2008
From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy
Y Qian, E Feldman, S Pennathur, M Kretzler, FC Brosius
Diabetes 2008
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MC Wagner, G Rhodes, E Wang, V Pruthi, E Arif, MA Saleem, SE Wean, P Garg, R Verma, LB Holzman, V Gattone, BA Molitoris, D Nihalani
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E Kiss-Tóth, T Roszer
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P Fioretto, ML Caramori, M Mauer
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JA Jefferson, SJ Shankland, RH Pichler
Kidney International 2008
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A Stirban, P Rösen, D Tschoepe
Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine 2008
Rosuvastatin protects against podocyte apoptosis in vitro
FC Cormack-Aboud, PT Brinkkoetter, JW Pippin, SJ Shankland, RV Durvasula
Nephrology Dialysis Transplantation 2008
Predictive power of sequential measures of albuminuria for progression to ESRD or death in Pima Indians with type 2 diabetes
ME Pavkov, WC Knowler, RL Hanson, PH Bennett, RG Nelson
American journal of kidney diseases : the official journal of the National Kidney Foundation 2008
Diagnostic biomarkers of diabetic nephropathy
H Ito, H Fujita, T Takahashi
Expert Opinion on Medical Diagnostics 2008
Expression of Alpha-actinin-4 in Human Diabetic Nephropathy
M Kimura, M Toyoda, M Kato, K Kobayashi, M Abe, T Kobayashi, M Miyauchi, N Yamamoto, T Umezono, D Suzuki
Internal Medicine 2008
The Notch pathway in podocytes plays a role in the development of glomerular disease
T Niranjan, B Bielesz, A Gruenwald, MP Ponda, JB Kopp, DB Thomas, K Susztak
Nature Medicine 2008
Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death
T Tejada, P Catanuto, A Ijaz, JV Santos, X Xia, P Sanchez, N Sanabria, O Lenz, SJ Elliot, A Fornoni
Kidney International 2008
Podocyte foot process effacement as a diagnostic tool in focal segmental glomerulosclerosis
JK Deegens, HB Dijkman, GF Borm, EJ Steenbergen, JG van Berg, JJ Weening, JF Wetzels
Kidney International 2008
Diabetic nephropathy in American Indians, with a special emphasis on the pima Indians
ME Pavkov, WC Knowler, RL Hanson, RG Nelson
Current Diabetes Reports 2008
Applications of LDL-apheresis in nephrology
S Kobayashi
Clinical and Experimental Nephrology 2008
Renin–angiotensin system blockade in diabetic nephropathy
J Ahmad
Diabetes and Metabolic Syndrome Clinical Research and Reviews 2008
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F Bonnet
Médecine des Maladies Métaboliques 2008
Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via α3β1 integrin upregulation and integrin-linked kinase inhibition
J Chen, D Gui, Y Chen, L Mou, Y Liu, J Huang
Biochemical Pharmacology 2008
G/T Substitution in Intron 1 of the UNC13B Gene Is Associated With Increased Risk of Nephropathy in Patients With Type 1 Diabetes
DA Tregouet, PH Groop, S McGinn, C Forsblom, S Hadjadj, M Marre, HH Parving, L Tarnow, R Telgmann, T Godefroy, V Nicaud, R Rousseau, M Parkkonen, A Hoverfalt, I Gut, S Heath, F Matsuda, R Cox, G Kazeem, M Farrall, D Gauguier, SM Brand-Herrmann, F Cambien, M Lathrop, N Vionnet
Diabetes 2008
Diabetic Nephropathy in American Indians, with a Special Emphasis on the Pima Indians
ME Pavkov, WC Knowler, RL Hanson, RG Nelson
Current Diabetes Reports 2008
Podocyte specific knock out of selenoproteins does not enhance nephropathy in streptozotocin diabetic C57BL/6 mice
MN Blauwkamp, J Yu, ML Schin, KA Burke, MJ Berry, BA Carlson, FC Brosius, RJ Koenig
BMC Nephrology 2008
Ischemic Injury to Kidney Induces Glomerular Podocyte Effacement and Dissociation of Slit Diaphragm Proteins Neph1 and ZO-1
MC Wagner, G Rhodes, E Wang, V Pruthi, E Arif, MA Saleem, SE Wean, P Garg, R Verma, LB Holzman, V Gattone, BA Molitoris, D Nihalani
The Journal of biological chemistry 2008
Activation of a local renin angiotensin system in podocytes by glucose
RV Durvasula, SJ Shankland
American journal of physiology. Renal physiology 2008
Rosiglitazone reduces renal and plasma markers of oxidative injury and reverses urinary metabolite abnormalities in the amelioration of diabetic nephropathy
H Zhang, J Saha, J Byun, ML Schin, M Lorenz, RT Kennedy, M Kretzler, EL Feldman, S Pennathur, FC Brosius
American journal of physiology. Renal physiology 2008
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