Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

J L Nichol; M M Hokom; A Hornkohl; W P Sheridan; H Ohashi; T Kato; Y S Li; T D Bartley; E Choi; J Bogenberger

doi:10.1172/JCI118005

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Nichol, J. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Hokom, M. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Hornkohl, A. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Sheridan, W. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Ohashi, H. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Kato, T. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Li, Y. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Bartley, T. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Choi, E. in: JCI | PubMed | Google Scholar

Amgen, Inc., Thousand Oaks, California 91320-1789, USA.

Find articles by Bogenberger, J. in: JCI | PubMed | Google Scholar

Published in Volume 95, Issue 6 on June 1, 1995
J Clin Invest. 1995;95(6):2973–2978. https://doi.org/10.1172/JCI118005.
© 1995 The American Society for Clinical Investigation

Published June 1, 1995 - Version history

The present study shows that recombinant human megakaryocyte growth and development factor (r-HuMGDF) behaves both as a megakaryocyte colony stimulating factor and as a differentiation factor in human progenitor cell cultures. Megakaryocyte colony formation induced with r-HuMGDF is synergistically affected by stem cell factor but not by interleukin 3. Megakaryocytes stimulated with r-HuMGDF demonstrate progressive cytoplasmic and nuclear maturation. Measurable levels of megakaryocyte growth and development factor in serum from patients undergoing myeloablative therapy and transplantation are shown to be elaborated in response to thrombocytopenic stress. These data support the concept that megakaryocyte growth and development factor is a physiologically regulated cytokine that is capable of supporting several aspects of megakaryopoiesis.

Images.

Version 1 (June 1, 1995): No description

Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

J L Nichol, M M Hokom, A Hornkohl, W P Sheridan, H Ohashi, T Kato, Y S Li, T D Bartley, E Choi, and J Bogenberger

Article tools

Metrics

Go to

Megakaryocyte growth and development factor. Analyses of in vitro effects on human megakaryopoiesis and endogenous serum levels during chemotherapy-induced thrombocytopenia.

J L Nichol, M M Hokom, A Hornkohl, W P Sheridan, H Ohashi, T Kato, Y S Li, T D Bartley, E Choi, and J Bogenberger

Article tools

Metrics

Go to

Sign up for email alerts