Citations to this article
Abstract
The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting for 28 and 21% of the genetic variability in systolic and diastolic blood pressures, respectively. Further, the genotype at this locus appears to determine the level of expression of the gene in the kidney. The findings provide strong evidence for a primary genetic involvement of the kidney in hypertension.
Authors
N J Samani, D Lodwick, M Vincent, C Dubay, M A Kaiser, M P Kelly, M Lo, J Harris, J Sassard, M Lathrop
Total citations by year
Citations to this article in year 2002 (4)
| Title and authors | Publication | Year |
|---|---|---|
|
Chromosome 1 blood pressure QTL region influences renal function curve and salt sensitivity in SHR
M Lo, KL Liu, JR Clemitson, J Sassard, NJ Samani |
Physiological genomics | 2002 |
|
Analyses of Differential Gene Expression in Genetic Hypertensive Rats by Microarray
T OKUDA, T SUMIYA, K MUZUTANI, N TAGO, T MIYATA, T TANABE, H KATO, T KATSUYA, J HIGAKI, T OGIHARA, Y TSUJITA, N IWAI |
Hypertension Research | 2002 |
|
The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model
N Ruiz-Opazo, LV Lopez, VL Herrera |
Molecular Medicine | 2002 |
|
Kidney Specificity of Rat Chromosome 1 Blood Pressure Quantitative Trait Locus Region
JR Clemitson, JR Pratt, S Frantz, S Sacks, NJ Samani |
Hypertension | 2002 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)