Citations to this article

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
N J Samani, … , J Sassard, M Lathrop
N J Samani, … , J Sassard, M Lathrop
Published August 1, 1993
Citation Information: J Clin Invest. 1993;92(2):1099-1103. https://doi.org/10.1172/JCI116616.
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A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.

Abstract

The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting for 28 and 21% of the genetic variability in systolic and diastolic blood pressures, respectively. Further, the genotype at this locus appears to determine the level of expression of the gene in the kidney. The findings provide strong evidence for a primary genetic involvement of the kidney in hypertension.

Authors

N J Samani, D Lodwick, M Vincent, C Dubay, M A Kaiser, M P Kelly, M Lo, J Harris, J Sassard, M Lathrop

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Citations to this article in year 1998 (9)

Title and authors Publication Year
Molecular cloning of KS, a novel rat gene expressed exclusively in the kidney
KF Hilgers, SK Nagaraj, EA Karginova, IG Kazakova, RL Chevalier, RM Carey, ES Pentz, RA Gomez 		Kidney International 1998
Hypertension
P Hamet, Z Pausova, V Adarichev, K Adaricheva, J Tremblay 		Journal of Hypertension 1998
Genetic analysis of the SA and Na+/K+-ATPase α1 genes in the Milan hypertensive rat
D Lodwick, L Zagato, MA Kaiser, L Torielli, G Casari, G Bianchi, NJ Samani 		Journal of Hypertension 1998
A primer on the genetics of hypertension
D Cusi, G Bianchi 		Kidney International 1998
Isolation of genes identified in mouse renal proximal tubule by comparing different gene expression profiles
M Takenaka, E Imai, T Kaneko, T Ito, T Moriyama, A Yamauchi, M Hori, S Kawamoto, K Okubo 		Kidney International 1998
Successful Isolation of a Rat Chromosome 1 Blood Pressure Quantitative Trait Locus in Reciprocal Congenic Strains
SA Frantz, M Kaiser, SM Gardiner, D Gauguier, M Vincent, JR Thompson, T Bennett, NJ Samani 		Hypertension 1998
Editorial Commentary: The Sa Gene: What Does It Mean?
J Rapp 		Hypertension 1998
Isolation of a Chromosome 1 Region That Contributes to High Blood Pressure and Salt Sensitivity
N Iwai, Y Tsujita, M Kinoshita 		Hypertension 1998
Salt Susceptibility Maps to Chromosomes 1 and 17 With Sex Specificity in the Sabra Rat Model of Hypertension
C Yagil, M Sapojnikov, R Kreutz, G Katni, K Lindpaintner, D Ganten, Y Yagil 		Hypertension 1998

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