Citations to this article

A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.
N J Samani, … , J Sassard, M Lathrop
N J Samani, … , J Sassard, M Lathrop
Published August 1, 1993
Citation Information: J Clin Invest. 1993;92(2):1099-1103. https://doi.org/10.1172/JCI116616.
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A gene differentially expressed in the kidney of the spontaneously hypertensive rat cosegregates with increased blood pressure.

Abstract

The role of the kidney in initiating hypertension has been much debated. Here we demonstrate that a recently identified gene of yet unknown function, termed SA, which is differentially expressed in the kidney of the spontaneously hypertensive rat, cosegregates with an increase in blood pressure in F2 rats derived from a cross of the spontaneously hypertensive rat with normotensive Wistar-Kyoto rats, accounting for 28 and 21% of the genetic variability in systolic and diastolic blood pressures, respectively. Further, the genotype at this locus appears to determine the level of expression of the gene in the kidney. The findings provide strong evidence for a primary genetic involvement of the kidney in hypertension.

Authors

N J Samani, D Lodwick, M Vincent, C Dubay, M A Kaiser, M P Kelly, M Lo, J Harris, J Sassard, M Lathrop

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Citations to this article in year 1997 (9)

Title and authors Publication Year
Genetic isolation of a region of chromosome 8 that exerts major effects on blood pressure and cardiac mass in the spontaneously hypertensive rat
V Kren, M Pravenec, S Lu, D Krenova, JM Wang, N Wang, T Merriouns, A Wong, ES Lezin, D Lau, C Szpirer, J Szpirer, TW Kurtz 		Journal of Clinical Investigation 1997
A pharmacogenetic approach to blood pressure in Lyon hypertensive rats. A chromosome 2 locus influences the response to a calcium antagonist
M Vincent, NJ Samani, D Gauguier, JR Thompson, GM Lathrop, J Sassard 		Journal of Clinical Investigation 1997
Comparative mapping of novel simple sequence repeat markers in a hypertension-related region on rat chromosome 1
T Nabika, T Ito, K Kitada, T Serikawa, T Mashimo, F Soubrier, C Julier, Y Ohno, T Saruta, H Tanase, J Masuda, Y Yamori, Y Nara 		Mammalian Genome 1997
Rat Chromosome 1: Regional localization of seven genes (Slc9a3, Srd5a1, Esr, Tcp1, Grik5, Tnnt3, Jak2) and anchoring of the genetic linkage map to the cytogenetic map
C Szpirer, J Szpirer, F Tissir, E Stephanova, P Vanvooren, TW Kurtz, N Iwai, T Inagami, M Pravenec, V Kren, K Klinga-Levan, G Levan 		Mammalian Genome 1997
Polymorphisms in the carboxy-terminus of the epithelial sodium channel in rat models for hypertension
S Gründer, L Zagato, C Yagil, Y Yagil, J Sassard, BC Rossier 		Journal of Hypertension 1997
RE-EVALUATION OF THE SA GENE IN SPONTANEOUSLY HYPERTENSIVE AND WISTAR-KYOTO RATS
Y Ishinaga, T Nabika, T Shimada, J Hiraoka, Y Nara, Y Yamori 		Clinical and Experimental Pharmacology and Physiology 1997
Diabetes and hypertension in rodent models
I Klöting, S Berg, P Kovács, B Voigt, L Vogt, S Schmidt 		Annals of the New York Academy of Sciences 1997
Genetic Isolation of a Chromosome 1 Region Affecting Blood Pressure in the Spontaneously Hypertensive Rat
ES Lezin, W Liu, JM Wang, N Wang, V Kren, D Krenova, A Musilova, M Zdobinska, V Zidek, D Lau, M Pravenec 		Hypertension 1997
Role of the α-, β-, and γ-Subunits of Epithelial Sodium Channel in a Model of Polygenic Hypertension
R Kreutz, B Struk, S Rubattu, N Hübner, J Szpirer, C Szpirer, D Ganten, K Lindpaintner 		Hypertension 1997

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