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Abstract
To elucidate the role of proteinase inhibitors in the regulation of protein breakdown in vivo, we measured the effect of leupeptin on the rate of appearance of leucine in the plasma compartment in overnight-fasted conscious dogs. Two groups of dogs were studied. The control group (I) received saline infusion, and the experimental group (II) was rendered hypercatabolic with daily administration of adrenocorticotropic hormone (ACTH) (500 U/d) for 4 d.
Authors
Ben McCallister, William W. Lacy, Phillip E. Williams, Naji N. Abumrad
Citation information
Citations to this article (5)
| Title and authors | Publication | Year |
|---|---|---|
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Disparate responses of cultured skeletal muscle cells and growing chicks to tripeptide aldehyde protease inhibitors and an in vivo interaction with ethanol
JC Fuller, GA Link, TW Huiatt, JL Sell, S Nissen |
The Journal of Nutritional Biochemistry | 1992 |
|
Influence of glucocorticoids on skeletal muscle proteolysis in normal and diabetic-adrenalectomized eviscerated rats
OL Smith, CY Wong, RA Gelfand |
Metabolism | 1990 |
|
Proteases II
WH Hörl, A Heidland |
1988 | |
|
Comparative Studies on Protein Turnover Regulations in Tumor Cells and Host Tissues: Development and Analysis of an Experimental Model
L Tessitore, G Bonelli, C Isidoro, OV Kazakova, FM Baccino |
Toxicologic pathology | 1986 |
|
Leupeptin's effect on organ weight, RNA, DNA, and protein content after long bone fracture in the rat
BM Miller, B Hoxworth, R Buckspan, L Nanney, WW Lacy, NN Abumrad |
Journal of Surgical Research | 1984 |
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