Leupeptin Inhibits Adrenocorticotropic Hormone-induced Protein Breakdown in the Conscious Dog

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Abstract

To elucidate the role of proteinase inhibitors in the regulation of protein breakdown in vivo, we measured the effect of leupeptin on the rate of appearance of leucine in the plasma compartment in overnight-fasted conscious dogs. Two groups of dogs were studied. The control group (I) received saline infusion, and the experimental group (II) was rendered hypercatabolic with daily administration of adrenocorticotropic hormone (ACTH) (500 U/d) for 4 d.

Authors

Ben McCallister, William W. Lacy, Phillip E. Williams, Naji N. Abumrad