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Research Article Free access | 10.1172/JCI107948

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.

J A Sandler, R I Clyman, V C Manganiello, and M Vaughan

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Published February 1, 1975 - More info

Published in Volume 55, Issue 2 on February 1, 1975
J Clin Invest. 1975;55(2):431–435. https://doi.org/10.1172/JCI107948.
© 1975 The American Society for Clinical Investigation
Published February 1, 1975 - Version history
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Abstract

The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...

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