The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.
J A Sandler, … , V C Manganiello, M Vaughan
J A Sandler, … , V C Manganiello, M Vaughan
Published February 1, 1975
Citation Information: J Clin Invest. 1975;55(2):431-435. https://doi.org/10.1172/JCI107948.
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Research Article

The effect of serotonin (5-hydroxytryptamine) and derivatives on guanosine 3',5'-monophosphate in human monocytes.

Abstract

The effects of several putative mediators of inflammatory responses on the cyclic nucleotide content of mononuclear leukocytes from human peripheral blood were investigated. Incubation of mononuclear cells with 100 muM serotonin (a maximally effective concentration) for 5 min caused a five- to eightfold increase in their content of guanosine 3',5'-monophosphate (cAMP)...

Authors

J A Sandler, R I Clyman, V C Manganiello, M Vaughan

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Other pages:
431 432 433 434 435

Other pages:
431 432 433 434 435