Impaired urinary concentration after vasopressin and its gradual correction in hypothalamic diabetes insipidus

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Abstract

This study utilized rates with hereditary hypothalamic diabetes insipidus (D.I.) in order to explore possible mechanisms which prevent full urinary concentration after acute administration of vasopressin in hypothalamic D.I. and which correct this concentrating defect with prolonged therapy.

Authors

Avery R. Harrington, Heinz Valtin