Issue published December 15, 1997 Previous issue | Next issue
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Editorials
T D GilmoreT D GilmorePublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2935-2936. https://doi.org/10.1172/JCI119843.
H Rabb, J G MartinH Rabb, J G MartinPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2937-2938. https://doi.org/10.1172/JCI119844.×Abstract
Editorial
Authors
H Rabb, J G Martin
J H VaughanJ H VaughanPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2939-2940. https://doi.org/10.1172/JCI119845.×Abstract
Editorial
Authors
J H Vaughan
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Perspectives
J Licinio, M L WongJ Licinio, M L WongPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2941-2947. https://doi.org/10.1172/JCI119846.×Abstract
Perspective
Authors
J Licinio, M L Wong
D E GriffinD E GriffinPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2948-2951. https://doi.org/10.1172/JCI119847.×Abstract
Perspective
Authors
D E Griffin
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Research Articles
M A Sovak, … , A M Traish, G E SonensheinM A Sovak, … , A M Traish, G E SonensheinPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2952-2960. https://doi.org/10.1172/JCI119848.×Abstract
Research Article
Authors
M A Sovak, R E Bellas, D W Kim, G J Zanieski, A E Rogers, A M Traish, G E Sonenshein
R C Bargou, … , C Scheidereit, B DörkenR C Bargou, … , C Scheidereit, B DörkenPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2961-2969. https://doi.org/10.1172/JCI119849.×Abstract
Research Article
Authors
R C Bargou, F Emmerich, D Krappmann, K Bommert, M Y Mapara, W Arnold, H D Royer, E Grinstein, A Greiner, C Scheidereit, B Dörken
C J van der Laken, … , F H Corstens, J W van der MeerC J van der Laken, … , F H Corstens, J W van der MeerPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2970-2976. https://doi.org/10.1172/JCI119850.×Abstract
Research Article
Authors
C J van der Laken, O C Boerman, W J Oyen, M T van de Ven, R Chizzonite, F H Corstens, J W van der Meer
M Wada, … , H Ishii, N NaganoM Wada, … , H Ishii, N NaganoPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2977-2983. https://doi.org/10.1172/JCI119851.×Abstract
Research Article
Authors
M Wada, Y Furuya, J Sakiyama, N Kobayashi, S Miyata, H Ishii, N Nagano
E A Kallio, … , K Vaali, K B LemstömE A Kallio, … , K Vaali, K B LemstömPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2984-2994. https://doi.org/10.1172/JCI119852.×Abstract
Research Article
Authors
E A Kallio, P K Koskinen, E Aavik, K Vaali, K B Lemstöm
K Horie, … , J L Witztum, K KurokawaK Horie, … , J L Witztum, K KurokawaPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):2995-3004. https://doi.org/10.1172/JCI119853.×Abstract
Research Article
Authors
K Horie, T Miyata, K Maeda, S Miyata, S Sugiyama, H Sakai, C van Ypersole de Strihou, V M Monnier, J L Witztum, K Kurokawa
V Large, … , L Lannfelt, P ArnerV Large, … , L Lannfelt, P ArnerPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3005-3013. https://doi.org/10.1172/JCI119854.×Abstract
Research Article
Authors
V Large, L Hellström, S Reynisdottir, F Lönnqvist, P Eriksson, L Lannfelt, P Arner
W Sun, … , S W Barthold, E FikrigW Sun, … , S W Barthold, E FikrigPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3014-3018. https://doi.org/10.1172/JCI119855.×Abstract
Research Article
Authors
W Sun, J W IJdo, S R Telford 3rd, E Hodzic, Y Zhang, S W Barthold, E Fikrig
J A James, … , T J Lehman, J B HarleyJ A James, … , T J Lehman, J B HarleyPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3019-3026. https://doi.org/10.1172/JCI119856.×Abstract
Research Article
Authors
J A James, K M Kaufman, A D Farris, E Taylor-Albert, T J Lehman, J B Harley
P I Karachunski, … , D K Okita, B M Conti-FineP I Karachunski, … , D K Okita, B M Conti-FinePublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3027-3035. https://doi.org/10.1172/JCI119857.×Abstract
Research Article
Authors
P I Karachunski, N S Ostlie, D K Okita, B M Conti-Fine
N Sharfe, … , M Shahar, C M RoifmanN Sharfe, … , M Shahar, C M RoifmanPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3036-3043. https://doi.org/10.1172/JCI119858.×Abstract
Research Article
Authors
N Sharfe, M Shahar, C M Roifman
H Ohnishi, … , S A Ernst, J A WilliamsH Ohnishi, … , S A Ernst, J A WilliamsPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3044-3052. https://doi.org/10.1172/JCI119859.×Abstract
Research Article
Authors
H Ohnishi, L C Samuelson, D I Yule, S A Ernst, J A Williams
M Akao, … , T Murakami, S SasayamaM Akao, … , T Murakami, S SasayamaPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3053-3059. https://doi.org/10.1172/JCI119860.×Abstract
Research Article
Authors
M Akao, H Otani, M Horie, M Takano, A Kuniyasu, H Nakayama, I Kouchi, T Murakami, S Sasayama
G Kent, … , M Buchwald, A K TanswellG Kent, … , M Buchwald, A K TanswellPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3060-3069. https://doi.org/10.1172/JCI119861.×Abstract
Research Article
Authors
G Kent, R Iles, C E Bear, L J Huan, U Griesenbach, C McKerlie, H Frndova, C Ackerley, D Gosselin, D Radzioch, H O'Brodovich, L C Tsui, M Buchwald, A K Tanswell
B Zhou, … , J Hammarback, M RabinovitchB Zhou, … , J Hammarback, M RabinovitchPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3070-3082. https://doi.org/10.1172/JCI119862.×Abstract
Research Article
Authors
B Zhou, N Boudreau, C Coulber, J Hammarback, M Rabinovitch
W R Henderson Jr, … , P E Christie, J M HarlanW R Henderson Jr, … , P E Christie, J M HarlanPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3083-3092. https://doi.org/10.1172/JCI119863.×Abstract
Research Article
Authors
W R Henderson Jr, E Y Chi, R K Albert, S J Chu, W J Lamm, Y Rochon, M Jonas, P E Christie, J M Harlan
S M Monte, … , H A Ghanbari, J R WandsS M Monte, … , H A Ghanbari, J R WandsPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3093-3104. https://doi.org/10.1172/JCI119864.×Abstract
Research Article
Authors
S M Monte, K Ghanbari, W H Frey, I Beheshti, P Averback, S L Hauser, H A Ghanbari, J R Wands
N Barzilai, … , M Hawkins, L RossettiN Barzilai, … , M Hawkins, L RossettiPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3105-3110. https://doi.org/10.1172/JCI119865.×Abstract
Research Article
Authors
N Barzilai, J Wang, D Massilon, P Vuguin, M Hawkins, L Rossetti
P A Rufo, … , S L Alper, W I LencerP A Rufo, … , S L Alper, W I LencerPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3111-3120. https://doi.org/10.1172/JCI119866.×Abstract
Research Article
Authors
P A Rufo, D Merlin, M Riegler, M H Ferguson-Maltzman, B L Dickinson, C Brugnara, S L Alper, W I Lencer
S D Mittelman, … , G Steil, R N BergmanS D Mittelman, … , G Steil, R N BergmanPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3121-3130. https://doi.org/10.1172/JCI119867.×Abstract
Research Article
Authors
S D Mittelman, Y Y Fu, K Rebrin, G Steil, R N Bergman
A Papapetropoulos, … , J A Madri, W C SessaA Papapetropoulos, … , J A Madri, W C SessaPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3131-3139. https://doi.org/10.1172/JCI119868.×Abstract
Research Article
Authors
A Papapetropoulos, G García-Cardeña, J A Madri, W C Sessa
D A Frank, … , S Mahajan, J RitzD A Frank, … , S Mahajan, J RitzPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3140-3148. https://doi.org/10.1172/JCI119869.×Abstract
Research Article
Authors
D A Frank, S Mahajan, J Ritz
M Adams, … , V K Chatterjee, S O'RahillyM Adams, … , V K Chatterjee, S O'RahillyPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3149-3153. https://doi.org/10.1172/JCI119870.×Abstract
Research Article
Authors
M Adams, C T Montague, J B Prins, J C Holder, S A Smith, L Sanders, J E Digby, C P Sewter, M A Lazar, V K Chatterjee, S O'Rahilly
C Söderberg-Nauclér, … , K N Fish, J A NelsonC Söderberg-Nauclér, … , K N Fish, J A NelsonPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3154-3163. https://doi.org/10.1172/JCI119871.×Abstract
Research Article
Authors
C Söderberg-Nauclér, K N Fish, J A Nelson
Nada J. Kerouz, … , Sebastian Pons, C. Ronald KahnNada J. Kerouz, … , Sebastian Pons, C. Ronald KahnPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3164-3172. https://doi.org/10.1172/JCI119872.×Abstract
Intracellular insulin signaling involves a series of alternative and complementary pathways created by the multiple substrates of the insulin receptor (IRS) and the various isoforms of SH2 domain signaling molecules that can interact with these substrates. In this study, we have evaluated the roles of IRS-1 and IRS-2 in signaling to the phosphatidylinositol (PI) 3-kinase pathway in the ob/ob mouse, a model of the insulin resistance of obesity and non-insulin-dependent diabetes mellitus. We find that the levels of expression of both IRS-1 and IRS-2 are decreased approximately 50% in muscle, whereas in liver the decrease is significantly greater for IRS-2 (72%) than for IRS-1 (29%). This results in differential decreases in IRS-1 and IRS-2 phosphorylation, docking of the p85alpha regulatory subunit of PI 3-kinase, and activation of this enzyme in these two insulin target tissues. In ob/ob liver there is also a change in expression of the alternatively spliced isoforms of the regulatory subunits for PI 3-kinase that was detected at the protein and mRNA level. This resulted in a 45% decrease in the p85alpha form of PI 3-kinase, a ninefold increase in the AS53/p55alpha, and a twofold increase in p50alpha isoforms. Thus, there are multiple alterations in the early steps of insulin signaling in the ob/ob mouse, with differential regulation of IRS-1 and IRS-2, various PI 3-kinase regulatory isoforms, and a lack of compensation for the decrease in insulin signaling by any of the known alternative pathways at these levels.
Authors
Nada J. Kerouz, Dieter Hörsch, Sebastian Pons, C. Ronald Kahn
A D Wells, … , H Gudmundsdottir, L A TurkaA D Wells, … , H Gudmundsdottir, L A TurkaPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3173-3183. https://doi.org/10.1172/JCI119873.×Abstract
Research Article
Authors
A D Wells, H Gudmundsdottir, L A Turka
F D Martinez, … , S Solomon, R EricksonF D Martinez, … , S Solomon, R EricksonPublished December 15, 1997
Citation Information: J Clin Invest. 1997;100(12):3184-3188. https://doi.org/10.1172/JCI119874.×Abstract
Research Article
Authors
F D Martinez, P E Graves, M Baldini, S Solomon, R Erickson
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