After an ovarian tumor forms, clumps of cancer cells are shed from the surface and released into the peritoneal cavity. These clumps then float around until they come into contact with another...
Published September 4, 2012

Muscular dystrophy is caused by mutations in the genes that code for the proteins that form a structural bridge between muscle cells and the extracellular matrix (ECM). Loss of this bridge...
Published August 27, 2012

Neutrophils play a critical role in mediating injury following ischemia and reperfustion, but the dynamic regulation of leukocyte recruitment has been difficult to study in vivo. In this article,...
Published June 19, 2012

Infection with filamentous fungi is a major cause of blindness. In this article, Leal et al.  examined the role of reactive oxygen species in killing fungal infections in the eye. Here, mouse eyes...
Published June 18, 2012

In sections of grey matter from mice, reactive astrocytes are stained to show GFAP (red), Vegf-A (green) and nuclei (blue). Disruption of the blood brain barrier is an early clinical feature of...
Published June 1, 2012

Laser-scanning microscopy of osteoclasts showing binding of autoantibodies against citrullinated vimentin to the surface (green), phalloidin (red) and nuclei (blue). Harre and colleagues show...
Published April 23, 2012

Cultured hippocampal neurons are stained for phosphorylated IRS-1 (red) and Aβ oligomers (AβOs, blue). AβOs are diffusible synaptotoxins that accumulate in the brains of Alzheimer disease (AD)...
Published March 26, 2012

Confocal maximum Z projections of MEFs in metaphase, immunostained for α-tubulin (violet), γ- tubulin (yellow) and DAPI (blue). Casimiro et al. show that in contrast to Cyclin D1-/- cells...
Published February 7, 2012

Dr. Tomoaki Kato, of Columbia University, removed an abdominal myxoid round cell liposarcoma (MRCLS) from a patient described in Charytonowicz et al. The tumor had 4 segments, the largest...
Published February 1, 2012

HeLa cell expressing Myc-tagged mutant Spastin (green) and Reticulon 2B (red). Montenegro and colleagues demonstrate that mutations in the endoplasmic reticulum-shaping protein Reticulon 2...
Published January 9, 2012