Infection with filamentous fungi is a major cause of blindness. In this article, Leal et al.  examined the role of reactive oxygen species in killing fungal infections in the eye. Here, mouse eyes...
Published June 18, 2012

In sections of grey matter from mice, reactive astrocytes are stained to show GFAP (red), Vegf-A (green) and nuclei (blue). Disruption of the blood brain barrier is an early clinical feature of...
Published June 1, 2012

Laser-scanning microscopy of osteoclasts showing binding of autoantibodies against citrullinated vimentin to the surface (green), phalloidin (red) and nuclei (blue). Harre and colleagues show...
Published April 23, 2012

Cultured hippocampal neurons are stained for phosphorylated IRS-1 (red) and Aβ oligomers (AβOs, blue). AβOs are diffusible synaptotoxins that accumulate in the brains of Alzheimer disease (AD)...
Published March 26, 2012

Confocal maximum Z projections of MEFs in metaphase, immunostained for α-tubulin (violet), γ- tubulin (yellow) and DAPI (blue). Casimiro et al. show that in contrast to Cyclin D1-/- cells...
Published February 7, 2012

Dr. Tomoaki Kato, of Columbia University, removed an abdominal myxoid round cell liposarcoma (MRCLS) from a patient described in Charytonowicz et al. The tumor had 4 segments, the largest...
Published February 1, 2012

HeLa cell expressing Myc-tagged mutant Spastin (green) and Reticulon 2B (red). Montenegro and colleagues demonstrate that mutations in the endoplasmic reticulum-shaping protein Reticulon 2...
Published January 9, 2012

Airways from napthalene injured mouse lung. Volckaert and colleagues provide a conceptual framework for injury-induced epithelial regeneration in the lung by parabronchial smooth muscle cells.
Published October 10, 2011

Hsp27 expressing neurons (yellow) distinguished by double labeling for tubulin (red) and HSP27 (green). Ma and colleagues show that expression of heat shock protein 27 enhances restoration...
Published October 3, 2011

Normal inner ear harvested from a mouse at postnatal day 3 and injected with paint to visualize the cochlea (bottom) and endolymphatic sac (top). Choi and colleagues show that the sac and the...
Published October 3, 2011