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CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders
Xiuying Bai, … , David Goltzman, Andrew C. Karaplis
Xiuying Bai, … , David Goltzman, Andrew C. Karaplis
Published April 15, 2025
Citation Information: J Clin Invest. 2025;135(8):e193400. https://doi.org/10.1172/JCI193400.
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CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders

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Abstract

Authors

Xiuying Bai, Dengshun Miao, Sophia Xiao, Dinghong Qiu, René St-Arnaud, Martin Petkovich, Ajay Gupta, David Goltzman, Andrew C. Karaplis

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The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity
Xiang Chen, … , Seon Hee Chang, Chen Dong
Xiang Chen, … , Seon Hee Chang, Chen Dong
Published March 17, 2025
Citation Information: J Clin Invest. 2025;135(6):e191396. https://doi.org/10.1172/JCI191396.
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The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

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Abstract

Authors

Xiang Chen, Jia Hu, Yunfei Wang, Younghee Lee, Xiaohong Zhao, Huiping Lu, Gengzhen Zhu, Hui Wang, Yu Jiang, Fan Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xindong Liu, Xiaohu Wang, Seon Hee Chang, Chen Dong

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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures
Chester J. Kao, … , Won Jin Ho, Mark Yarchoan
Chester J. Kao, … , Won Jin Ho, Mark Yarchoan
Published March 17, 2025
Citation Information: J Clin Invest. 2025;135(6):e192014. https://doi.org/10.1172/JCI192014.
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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures

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Abstract

Authors

Chester J. Kao, Soren Charmsaz, Stephanie L. Alden, Madelena Brancati, Howard L. Li, Aanika Balaji, Kabeer Munjal, Kathryn Howe, Sarah Mitchell, James Leatherman, Ervin Griffin, Mari Nakazawa, Hua-Ling Tsai, Ludmila Danilova, Chris Thoburn, Jennifer Gizzi, Nicole E. Gross, Alexei Hernandez, Erin M. Coyne, Sarah M. Shin, Jayalaxmi Suresh Babu, George W. Apostol, Jennifer Durham, Brian J. Christmas, Maximilian F. Konig, Evan J. Lipson, Jarushka Naidoo, Laura C. Cappelli, Aliyah Pabani, Yasser Ged, Marina Baretti, Julie Brahmer, Jean Hoffman-Censits, Tanguy Y. Seiwert, Rachel Garonce-Hediger, Aditi Guha, Sanjay Bansal, Laura Tang, Elizabeth M. Jaffee, G. Scott Chandler, Rajat Mohindra, Won Jin Ho, Mark Yarchoan

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FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging
Hanjun Li, … , Zhengju Yao, Xizhi Guo
Hanjun Li, … , Zhengju Yao, Xizhi Guo
Published February 17, 2025
Citation Information: J Clin Invest. 2025;135(4):e191424. https://doi.org/10.1172/JCI191424.
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FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

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Authors

Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, Baojie Li, Ying Fan, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting Tang, Yongxin Ren, Haley O. Tucker, Zhengju Yao, Xizhi Guo

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Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
Qianru Huang, … , Qianjun Zhou, Bin Li
Qianru Huang, … , Qianjun Zhou, Bin Li
Published February 17, 2025
Citation Information: J Clin Invest. 2025;135(4):e191305. https://doi.org/10.1172/JCI191305.
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Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

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Authors

Qianru Huang, Na Tian, Jianfeng Zhang, Shiyang Song, Hao Cheng, Xinnan Liu, Wenle Zhang, Youqiong Ye, Yanhua Du, Xueyu Dai, Rui Liang, Dan Li, Sheng-Ming Dai, Chuan Wang, Zhi Chen, Qianjun Zhou, Bin Li

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Parkin activates innate immunity and promotes antitumor immune responses
Michela Perego, … , Noam Auslander, Dario C. Altieri
Michela Perego, … , Noam Auslander, Dario C. Altieri
Published January 16, 2025
Citation Information: J Clin Invest. 2025;135(2):e190291. https://doi.org/10.1172/JCI190291.
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Parkin activates innate immunity and promotes antitumor immune responses

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Authors

Michela Perego, Minjeong Yeon, Ekta Agarwal, Andrew T. Milcarek, Irene Bertolini, Chiara Camisaschi, Jagadish C. Ghosh, Hsin-Yao Tang, Nathalie Grandvaux, Marcus Ruscetti, Andrew V. Kossenkov, Sarah Preston-Alp, Italo Tempera, Noam Auslander, Dario C. Altieri

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CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA
Honghe Liu, … , Lindsey R. Hayes, Jiou Wang
Honghe Liu, … , Lindsey R. Hayes, Jiou Wang
Published December 16, 2024
Citation Information: J Clin Invest. 2024;134(24):e189439. https://doi.org/10.1172/JCI189439.
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CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA

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Authors

Honghe Liu, Xiao-Feng Zhao, Yu-Ning Lu, Lindsey R. Hayes, Jiou Wang

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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study
Wilson X. Wang, … , Jonathan J. Miner, Rajendra S. Apte
Wilson X. Wang, … , Jonathan J. Miner, Rajendra S. Apte
Published December 16, 2024
Citation Information: J Clin Invest. 2024;134(24):e189023. https://doi.org/10.1172/JCI189023.
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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study

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Authors

Wilson X. Wang, Dan Spiegelman, P. Kumar Rao, Rennie L. Rhee, Andria L. Ford, Jonathan J. Miner, Rajendra S. Apte

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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
Jingzhong Ding, … , John S. Parks, Yongmei Liu
Jingzhong Ding, … , John S. Parks, Yongmei Liu
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e185290. https://doi.org/10.1172/JCI185290.
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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

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Abstract

Authors

Jingzhong Ding, Anh Tram Nguyen, Kurt Lohman, Michael T. Hensley, Daniel Parker, Li Hou, Jackson Taylor, Deepak Voora, Janet K. Sawyer, Elena Boudyguina, Michael P. Bancks, Alain Bertoni, James S. Pankow, Jerome I. Rotter, Mark O. Goodarzi, Russell P. Tracy, David M. Murdoch, Daniel Duprez, Stephen S. Rich, Bruce M. Psaty, David Siscovick, Christopher B. Newgard, David Herrington, Ina Hoeschele, Steven Shea, James H. Stein, Manesh Patel, Wendy Post, David Jacobs Jr., John S. Parks, Yongmei Liu

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target
Quy Le, … , Keith R. Loeb, Soheil Meshinchi
Quy Le, … , Keith R. Loeb, Soheil Meshinchi
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e184305. https://doi.org/10.1172/JCI184305.
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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

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Abstract

Authors

Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi

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