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68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer
Ke Li, … , Shaoli Song, Shuang Tang
Ke Li, … , Shaoli Song, Shuang Tang
Published April 15, 2024
Citation Information: J Clin Invest. 2024;134(8):e181374. https://doi.org/10.1172/JCI181374.
View: Text | PDF | Amended Article

68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer

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Authors

Ke Li, Wei Liu, Hang Yu, Jiwei Chen, Wenxuan Tang, Jianpeng Wang, Ming Qi, Yuyun Sun, Xiaoping Xu, Ji Zhang, Xinxiang Li, Weijian Guo, Xiaoling Li, Shaoli Song, Shuang Tang

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Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes
Nicolas Skuli, … , Brian Keith, M. Celeste Simon
Nicolas Skuli, … , Brian Keith, M. Celeste Simon
Published April 15, 2024
Citation Information: J Clin Invest. 2024;134(8):e180863. https://doi.org/10.1172/JCI180863.
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Endothelial HIF-2α regulates murine pathological angiogenesis and revascularization processes

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Authors

Nicolas Skuli, Amar J. Majmundar, Bryan L. Krock, Rickson C. Mesquita, Lijoy K. Mathew, Zachary L. Quinn, Anja Runge, Liping Liu, Meeri N. Kim, Jiaming Liang, Steven Schenkel, Arjun G. Yodh, Brian Keith, M. Celeste Simon

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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma
Yao Zhan, … , Wilson H. Miller Jr., Sonia V. del Rincón
Yao Zhan, … , Wilson H. Miller Jr., Sonia V. del Rincón
Published April 15, 2024
Citation Information: J Clin Invest. 2024;134(8):e181338. https://doi.org/10.1172/JCI181338.
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MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma

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Authors

Yao Zhan, Jun Guo, William Yang, Christophe Goncalves, Tomasz Rzymski, Agnieszka Dreas, Eliza Żyłkiewicz, Maciej Mikulski, Krzysztof Brzózka, Aniela Golas, Yan Kong, Meng Ma, Fan Huang, Bonnie Huor, Qianyu Guo, Sabrina Daniela da Silva, Jose Torres, Yutian Cai, Ivan Topisirovic, Jie Su, Krikor Bijian, Moulay A. Alaoui-Jamali, Sidong Huang, Fabrice Journe, Ghanem E. Ghanem, Wilson H. Miller Jr., Sonia V. del Rincón

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Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis
Dennis G. Moledina, … , F. Perry Wilson, Chirag R. Parikh
Dennis G. Moledina, … , F. Perry Wilson, Chirag R. Parikh
Published March 15, 2024
Citation Information: J Clin Invest. 2024;134(6):e180583. https://doi.org/10.1172/JCI180583.
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Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis

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Authors

Dennis G. Moledina, Wassim Obeid, Rex N. Smith, Ivy Rosales, Meghan E. Sise, Gilbert Moeckel, Michael Kashgarian, Michael Kuperman, Kirk N. Campbell, Sean Lefferts, Kristin Meliambro, Markus Bitzer, Mark A. Perazella, Randy L. Luciano, Jordan S. Pober, Lloyd G. Cantley, Robert B. Colvin, F. Perry Wilson, Chirag R. Parikh

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Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis
Nidhi S. Dey, … , Paul M. Kaye, Shalindra Ranasinghe
Nidhi S. Dey, … , Paul M. Kaye, Shalindra Ranasinghe
Published March 1, 2024
Citation Information: J Clin Invest. 2024;134(5):e180162. https://doi.org/10.1172/JCI180162.
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Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

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Authors

Nidhi S. Dey, Sujai Senaratne, Vijani Somaratne, Nayani P. Madarasinghe, Bimalka Seneviratne, Sarah Forrester, Marcela Montes de Oca, Luiza Campos Reis, Srija Moulik, Pegine B. Walrad, Mitali Chatterjee, Hiro Goto, Renu Wickremasinghe, Dimitris Lagos, Paul M. Kaye, Shalindra Ranasinghe

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Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice
Huihui Ma, … , Suzanne Lentzsch, Markus Y. Mapara
Huihui Ma, … , Suzanne Lentzsch, Markus Y. Mapara
Published March 1, 2024
Citation Information: J Clin Invest. 2024;134(5):e180350. https://doi.org/10.1172/JCI180350.
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Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice

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Authors

Huihui Ma, Caisheng Lu, Judith Ziegler, Ailing Liu, Antonia Sepulveda, Hideho Okada, Suzanne Lentzsch, Markus Y. Mapara

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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma
Annalisa D’Avola, … , Karen H. Vousden, John C. Riches
Annalisa D’Avola, … , Karen H. Vousden, John C. Riches
Published February 15, 2024
Citation Information: J Clin Invest. 2024;134(4):e179917. https://doi.org/10.1172/JCI179917.
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PHGDH is required for germinal center formation and is a therapeutic target in MYC-driven lymphoma

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Authors

Annalisa D’Avola, Nathalie Legrave, Mylène Tajan, Probir Chakravarty, Ryan L. Shearer, Hamish W. King, Katarina Kluckova, Eric C. Cheung, Andrew J. Clear, Arief S. Gunawan, Lingling Zhang, Louisa K. James, James I. MacRae, John G. Gribben, Dinis P. Calado, Karen H. Vousden, John C. Riches

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KBTBD13 is an actin-binding protein that modulates muscle kinetics
Josine M. de Winter, … , Nicol C. Voermans, Coen A.C. Ottenheijm
Josine M. de Winter, … , Nicol C. Voermans, Coen A.C. Ottenheijm
Published February 1, 2024
Citation Information: J Clin Invest. 2024;134(3):e179111. https://doi.org/10.1172/JCI179111.
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KBTBD13 is an actin-binding protein that modulates muscle kinetics

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Authors

Josine M. de Winter, Joery P. Molenaar, Michaela Yuen, Robbert van der Pijl, Shengyi Shen, Stefan Conijn, Martijn van de Locht, Menne Willigenburg, Sylvia J.P. Bogaards, Esmee S.B. van Kleef, Saskia Lassche, Malin Persson, Dilson E. Rassier, Tamar E. Sztal, Avnika A. Ruparelia, Viola Oorschot, Georg Ramm, Thomas E. Hall, Zherui Xiong, Christopher N. Johnson, Frank Li, Balazs Kiss, Noelia Lozano-Vidal, Reinier A. Boon, Manuela Marabita, Leonardo Nogara, Bert Blaauw, Richard J. Rodenburg, Benno Küsters, Jonne Doorduin, Alan H. Beggs, Henk Granzier, Ken Campbell, Weikang Ma, Thomas Irving, Edoardo Malfatti, Norma B. Romero, Robert J. Bryson-Richardson, Baziel G.M. van Engelen, Nicol C. Voermans, Coen A.C. Ottenheijm

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Cell-free DNA reveals distinct pathology of multisystem inflammatory syndrome in children
Temesgen E. Andargie, … , Andrea L. Cox, Sean Agbor-Enoh
Temesgen E. Andargie, … , Andrea L. Cox, Sean Agbor-Enoh
Published January 2, 2024
Citation Information: J Clin Invest. 2024;134(1):e178008. https://doi.org/10.1172/JCI178008.
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Cell-free DNA reveals distinct pathology of multisystem inflammatory syndrome in children

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Authors

Temesgen E. Andargie, Katerina Roznik, Neelam Redekar, Tom Hill, Weiqiang Zhou, Zainab Apalara, Hyesik Kong, Oren Gordon, Rohan Meda, Woojin Park, Trevor S. Johnston, Yi Wang, Sheila Brady, Hongkai Ji, Jack A. Yanovski, Moon K. Jang, Clarence M. Lee, Andrew H. Karaba, Andrea L. Cox, Sean Agbor-Enoh

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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
Florian Wiede, … , Dale I. Godfrey, Tony Tiganis
Florian Wiede, … , Dale I. Godfrey, Tony Tiganis
Published October 16, 2023
Citation Information: J Clin Invest. 2023;133(20):e175163. https://doi.org/10.1172/JCI175163.
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T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

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Authors

Florian Wiede, Benjamin J. Shields, Sock Hui Chew Konstantinos Kyparissoudis, Catherine van Vliet, Sandra Galic, Michel L. Tremblay, Sarah M. Russell, Dale I. Godfrey, Tony Tiganis

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