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ResearchIn-Press PreviewGastroenterologyImmunologyOncology
Open Access | 
10.1172/JCI181243
Gut microbial metabolite 4-hydroxybenzeneacetic acid drives colorectal cancer progression via accumulation of immunosuppressive PMN-MDSCs
Qing Liao,1 Ximing Zhou,2 Ling Wu,1 Yuyi Yang,2 Xiaohui Zhu,2 Hangyu Liao,2 Yujie Zhang,2 Weidong Lian,2 Feifei Zhang,3 Hui Wang,4 Yanqing Ding,2 and Liang Zhao1
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Liao, Q. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhou, X. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Wu, L. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Yang, Y. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhu, X. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Liao, H. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Lian, W. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Zhang, F. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Wang, H. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
Find articles by Ding, Y. in: JCI | PubMed | Google Scholar
1Department of Pathology, Shunde Hospital of Southern Medical University, Foshan, China
2Department of Pathology, Southern Medical University, Guangzhou, China
3Department of Plastic and Aesthetic Surgery, Southern Medical University, Guangzhou, China
4Department of Medical Oncology, Affiliated Tumour Hospital of Guangzhou Medical University, Guangzhou, China
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Zhao, L.
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Published April 3, 2025 - More info
Copyright © 2025, Liao et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)