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Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures
Chester J. Kao, … , Won Jin Ho, Mark Yarchoan
Chester J. Kao, … , Won Jin Ho, Mark Yarchoan
Published March 17, 2025
Citation Information: J Clin Invest. 2025;135(6):e192014. https://doi.org/10.1172/JCI192014.
View: Text | PDF | Amended Article

Immune-related events in individuals with solid tumors on immunotherapy associate with Th17 and Th2 signatures

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Authors

Chester J. Kao, Soren Charmsaz, Stephanie L. Alden, Madelena Brancati, Howard L. Li, Aanika Balaji, Kabeer Munjal, Kathryn Howe, Sarah Mitchell, James Leatherman, Ervin Griffin, Mari Nakazawa, Hua-Ling Tsai, Ludmila Danilova, Chris Thoburn, Jennifer Gizzi, Nicole E. Gross, Alexei Hernandez, Erin M. Coyne, Sarah M. Shin, Jayalaxmi Suresh Babu, George W. Apostol, Jennifer Durham, Brian J. Christmas, Maximilian F. Konig, Evan J. Lipson, Jarushka Naidoo, Laura C. Cappelli, Aliyah Pabani, Yasser Ged, Marina Baretti, Julie Brahmer, Jean Hoffman-Censits, Tanguy Y. Seiwert, Rachel Garonce-Hediger, Aditi Guha, Sanjay Bansal, Laura Tang, Elizabeth M. Jaffee, G. Scott Chandler, Rajat Mohindra, Won Jin Ho, Mark Yarchoan

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FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging
Hanjun Li, … , Zhengju Yao, Xizhi Guo
Hanjun Li, … , Zhengju Yao, Xizhi Guo
Published February 17, 2025
Citation Information: J Clin Invest. 2025;135(4):e191424. https://doi.org/10.1172/JCI191424.
View: Text | PDF | Amended Article

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

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Abstract

Authors

Hanjun Li, Pei Liu, Shuqin Xu, Yinghua Li, Joseph D. Dekker, Baojie Li, Ying Fan, Zhenlin Zhang, Yang Hong, Gong Yang, Tingting Tang, Yongxin Ren, Haley O. Tucker, Zhengju Yao, Xizhi Guo

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Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma
Qianru Huang, … , Qianjun Zhou, Bin Li
Qianru Huang, … , Qianjun Zhou, Bin Li
Published February 17, 2025
Citation Information: J Clin Invest. 2025;135(4):e191305. https://doi.org/10.1172/JCI191305.
View: Text | PDF | Amended Article

Nonclassical action of Ku70 promotes Treg-suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

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Abstract

Authors

Qianru Huang, Na Tian, Jianfeng Zhang, Shiyang Song, Hao Cheng, Xinnan Liu, Wenle Zhang, Youqiong Ye, Yanhua Du, Xueyu Dai, Rui Liang, Dan Li, Sheng-Ming Dai, Chuan Wang, Zhi Chen, Qianjun Zhou, Bin Li

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Parkin activates innate immunity and promotes antitumor immune responses
Michela Perego, … , Noam Auslander, Dario C. Altieri
Michela Perego, … , Noam Auslander, Dario C. Altieri
Published January 16, 2025
Citation Information: J Clin Invest. 2025;135(2):e190291. https://doi.org/10.1172/JCI190291.
View: Text | PDF | Amended Article

Parkin activates innate immunity and promotes antitumor immune responses

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Authors

Michela Perego, Minjeong Yeon, Ekta Agarwal, Andrew T. Milcarek, Irene Bertolini, Chiara Camisaschi, Jagadish C. Ghosh, Hsin-Yao Tang, Nathalie Grandvaux, Marcus Ruscetti, Andrew V. Kossenkov, Sarah Preston-Alp, Italo Tempera, Noam Auslander, Dario C. Altieri

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CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA
Honghe Liu, … , Lindsey R. Hayes, Jiou Wang
Honghe Liu, … , Lindsey R. Hayes, Jiou Wang
Published December 16, 2024
Citation Information: J Clin Invest. 2024;134(24):e189439. https://doi.org/10.1172/JCI189439.
View: Text | PDF | Amended Article

CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA

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Abstract

Authors

Honghe Liu, Xiao-Feng Zhao, Yu-Ning Lu, Lindsey R. Hayes, Jiou Wang

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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study
Wilson X. Wang, … , Jonathan J. Miner, Rajendra S. Apte
Wilson X. Wang, … , Jonathan J. Miner, Rajendra S. Apte
Published December 16, 2024
Citation Information: J Clin Invest. 2024;134(24):e189023. https://doi.org/10.1172/JCI189023.
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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study

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Authors

Wilson X. Wang, Dan Spiegelman, P. Kumar Rao, Rennie L. Rhee, Andria L. Ford, Jonathan J. Miner, Rajendra S. Apte

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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes
Jingzhong Ding, … , John S. Parks, Yongmei Liu
Jingzhong Ding, … , John S. Parks, Yongmei Liu
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e185290. https://doi.org/10.1172/JCI185290.
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LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes

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Authors

Jingzhong Ding, Anh Tram Nguyen, Kurt Lohman, Michael T. Hensley, Daniel Parker, Li Hou, Jackson Taylor, Deepak Voora, Janet K. Sawyer, Elena Boudyguina, Michael P. Bancks, Alain Bertoni, James S. Pankow, Jerome I. Rotter, Mark O. Goodarzi, Russell P. Tracy, David M. Murdoch, Daniel Duprez, Stephen S. Rich, Bruce M. Psaty, David Siscovick, Christopher B. Newgard, David Herrington, Ina Hoeschele, Steven Shea, James H. Stein, Manesh Patel, Wendy Post, David Jacobs Jr., John S. Parks, Yongmei Liu

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target
Quy Le, … , Keith R. Loeb, Soheil Meshinchi
Quy Le, … , Keith R. Loeb, Soheil Meshinchi
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e184305. https://doi.org/10.1172/JCI184305.
View: Text | PDF | Amended Article

CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

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Abstract

Authors

Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi

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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
Callum Beach, … , Amato J. Giaccia, Monica M. Olcina
Callum Beach, … , Amato J. Giaccia, Monica M. Olcina
Published August 15, 2024
Citation Information: J Clin Invest. 2024;134(16):e185067. https://doi.org/10.1172/JCI185067.
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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

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Abstract

Authors

Callum Beach, David MacLean, Dominika Majorova, Stavros Melemenidis, Dhanya K. Nambiar, Ryan K. Kim, Gabriel N. Valbuena, Silvia Guglietta, Carsten Krieg, Mahnaz Darvish-Damavandi, Tatsuya Suwa, Alistair Easton, Lily V.S. Hillson, Ashley K. McCulloch, Ross K. McMahon, Kathryn Pennel, Joanne Edwards, Sean M. O’Cathail, Campbell S. Roxburgh, Enric Domingo, Eui Jung Moon, Dadi Jiang, Yanyan Jiang, Qingyang Zhang, Albert C. Koong, Trent M. Woodruff, Edward E. Graves, Tim Maughan, Simon J.A. Buczacki, Manuel Stucki, Quynh-Thu Le, Simon J. Leedham, Amato J. Giaccia, Monica M. Olcina

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NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy
Stephen P. Chelko, … , Kory Lavine, Jeffrey E. Saffitz
Stephen P. Chelko, … , Kory Lavine, Jeffrey E. Saffitz
Published July 1, 2024
Citation Information: J Clin Invest. 2024;134(13):e183441. https://doi.org/10.1172/JCI183441.
View: Text | PDF | Amended Article

NFĸB signaling drives myocardial injury via CCR2+ macrophages in a preclinical model of arrhythmogenic cardiomyopathy

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Abstract

Authors

Stephen P. Chelko, Vinay R. Penna, Morgan Engel, Emily A. Shiel, Ann M. Centner, Waleed Farra, Elisa N. Cannon, Maicon Landim-Vieira, Niccole Schaible, Kory Lavine, Jeffrey E. Saffitz

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