First Author Perspectives

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An interview with Yulong Chen and Masahiko Terajima
Yulong Chen and Masahiko Terajima discuss their research published in the March 2015 issue of the JCI identifying a crosstalk mechanism by which lung tumor cells become more metastatic via alteration of the chemical nature of the collagen crossli
Published February 9, 2015
First Author Perspectives
An interview with Markus Huth
Markus Huth discusses research demonstrating that modification of a class of antibiotics known as aminoglycosides reduces detrimental side effects affecting hearing by blocking entry of the drugs into sensory hair cells cells via mechanotransduction chan
Published January 6, 2015
First Author Perspectives
An interview with Rupert Kenefeck
Rupert Kenefeck discusses research published in the January 2015 issue that provides a novel framework for therapeutic intervention and biomarker identification in the setting of type 1 diabetes.
Published December 11, 2014
First Author Perspectives
An interview with Jaerak Chang and Seongju Lee
In the December issue of the JCI, Jaerak Chang and Seongju Lee discuss their research into the mechanisms underlying two commonly mutated genes in hereditary spastic paraplegia
Published November 3, 2014
First Author Perspectives
An interview with Barbara Wegiel
In the November issue of the JCI, Wegiel et al. describe a unique mechanism whereby carbon monoxide (CO) produced by heme oxygenase 1 (HO-1) in macrophages results in ATP production by several bacteria.
Published October 8, 2014
First Author Perspectives
An interview with Alexander Gill
A research article in the October 2014 issue of the JCI describes the role of heme oxygenase–1 (HO-1) in the neuropathophysiology of HIV and suggests that HO-1 serves as a protective factor against neurodegeneration in HIV-associated neurocognitive disord
Published September 9, 2014
First Author Perspectives
An interview with Gaetano Santulli
A research article in the September 2014 issue of the JCI identifies a microRNA-based strategy that inhibits arterial restenosis while preserving endothelial function. The authors created an adenoviral vector encoding the cyclin-dependent kinase inhibitor
Published August 18, 2014
First Author Perspectives
An interview with Lilu Guo and Zhongyi Chen
In the August 2014 issue of the JCI, Chen et al. report that engineered bacteria can alter the gut microbiota and inhibit weight gain in a mouse model of obesity. The research team designed bacteria to produce a satiety factor known as N-acylphos
Published August 13, 2014
First Author Perspectives
An interview with Jamie Anastas
A research article in the July 2014 issue of JCI identifies resistance mechanisms of BRAF-mutant melanoma cells to targeted therapy among the WNT signaling pathways, specifically WNT5A. This research uncovers a means of acquired resistance to tar
Published July 11, 2014
First Author Perspectives
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