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Citation Information: J Clin Invest. 1974;54(5):1056-1063. https://doi.org/10.1172/JCI107849.
Abstract
The depletion of articular cartilage in the afflicted joints is a primary clinical feature of osteoarthritis. This disorder has been linked to a disturbance in the metabolism of the extracellular matrix components of this tissue. The mechanisms involved in the regulation of sulfated proteoglycan metabolism in articular cartilage were therefore studied by measuring the biosynthesis and distribution of 35S-labeled glycosaminoglycans in chondrocyte cultures derived from normal and osteoarthritic tissue. Incorporation experiments were carried out at pH 7.0 with [35S]Na2SO4 in the presence of fetal calf serum, human serum from normal or arthritic individuals, or a combination of these.
Authors
Edith R. Schwartz, P. Roger Kirkpatrick, Roby C. Thompson
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