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Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

Samir Softic, … , David E. Cohen, C. Ronald Kahn

Published March 1, 2018
Citation Information: J Clin Invest. 2018;128(3):1199-1199. https://doi.org/10.1172/JCI99009.

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Citations to this article (24)

Title and authors	Publication	Year
PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein Johnson SM, Bao H, McMahon CE, Chen Y, Burr SD, Anderson AM, Madeyski-Bengtson K, Lindén D, Han X, Liu J	Nature Communications	2024
Bioactive metabolites: A clue to the link between MASLD and CKD? Chen WY, Zhang JH, Chen LL, Byrne CD, Targher G, Luo L, Ni Y, Zheng MH, Sun DQ	Clinical and Molecular Hepatology	2024
The interplay between nonalcoholic fatty liver disease and atherosclerotic cardiovascular disease Finney AC, Das S, Kumar D, McKinney MP, Cai B, Yurdagul A Jr, Rom O	Frontiers in Cardiovascular Medicine	2023
The fructose survival hypothesis for obesity Johnson RJ, Lanaspa MA, Sanchez-Lozada LG, Tolan D, Nakagawa T, Ishimoto T, Andres-Hernando A, Rodriguez-Iturbe B, Stenvinkel P	Philosophical Transactions of the Royal Society B: Biological Sciences	2023
Micropatterned primary hepatocyte co-culture (HEPATOPAC) for fatty liver disease modeling and drug screening Cottier KE, Bhalerao D, Lewis C, Gaffney J, Heyward SA	Scientific Reports	2023
Serum Amyloid A is not obligatory for high-fat, high-sucrose, cholesterol-fed diet-induced obesity and its metabolic and inflammatory complications Ji A, Trumbauer AC, Noffsinger VP, Jeon H, Patrick AC, De Beer FC, Webb NR, Tannock LR, Shridas P	PloS one	2022
PIDDosome-SCAP crosstalk controls high fructose diet dependent transition from simple steatosis to steatohepatitis Kim JY, Wang LQ, Sladky VC, Oh TG, Liu J, Trinh K, Eichin F, Downes M, Hosseini M, Jacotot ED, Evans RM, Villunger A, Karin M	Cell Metabolism	2022
Helminth infection and helminth-derived products: A novel therapeutic option for non-alcoholic fatty liver disease Liu X, Jiang Y, Ye J, Wang X	Frontiers in immunology	2022
Lactational delivery of Triclosan promotes non-alcoholic fatty liver disease in newborn mice A Weber, X Yang, E Mennillo, J Ding, J Watrous, M Jain, S Chen, M Karin, R Tukey	Nature Communications	2022
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction JA Gutierrez, W Liu, S Perez, G Xing, G Sonnenberg, K Kou, M Blatnik, R Allen, Y Weng, NB Vera, K Chidsey, A Bergman, V Somayaji, C Crowley, MF Clasquin, A Nigam, MA Fulham, DM Erion, TT Ross, WP Esler, TV Magee, JA Pfefferkorn, KK Bence, MJ Birnbaum, GJ Tesz	Molecular Metabolism	2021
Molecular aspects of fructose metabolism and metabolic disease MA Herman, MJ Birnbaum	Cell Metabolism	2021
A Systems Approach Dissociates Fructose-Induced Liver Triglyceride from Hypertriglyceridemia and Hyperinsulinemia in Male Mice L Doridot, SA Hannou, SA Krawczyk, W Tong, MS Kim, GS McElroy, AJ Fowler, II Astapova, MA Herman	Nutrients	2021
Metabolic-associated fatty liver disease and lipoprotein metabolism J Heeren, L Scheja	Molecular Metabolism	2021
The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis D Carn, MA Lanaspa, SA Benner, P Andrews, R Dudley, A AndresHernando, DR Tolan, RJ Johnson	Alcoholism, clinical and experimental research	2021
Does weight change modify the association between the consumption of sugar-sweetened beverages and 100% fruit juice and the risk of metabolic syndrome? S Hosseinpour-Niazi, M Aghayan, P Mirmiran, F Azizi	Clinical nutrition (Edinburgh, Scotland)	2021
Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction A Andres-Hernando, DJ Orlicky, M Kuwabara, T Ishimoto, T Nakagawa, RJ Johnson, MA Lanaspa	Cell Metabolism	2020
High Fat-High Fructose Diet-Induced Changes in the Gut Microbiota Associated with Dyslipidemia in Syrian Hamsters Horne RG, Yu Y, Zhang R, Abdalqadir N, Rossi L, Surette M, Sherman PM, Adeli K	Nutrients	2020
Recent advances in fructose intake and risk of hyperuricemia C Zhang, L Li, Y Zhang, C Zeng	Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie	2020
When to lower triglycerides? OP Ganda	Current Opinion in Lipidology	2020
Administration of ursolic acid to new-born pups prevents dietary fructose-induced non-alcoholic fatty liver disease in Sprague Dawley rats NC Mukonowenzou, R Dangarembizi, E Chivandi, P Nkomozepi, KH Erlwanger	Journal of Developmental Origins of Health and Disease	2020
The potential efficacy of dietary fatty acids and fructose induced inflammation and oxidative stress on the insulin signaling and fat accumulation in mice F Tamer, E Ulug, A Akyol, R Nergiz-Unal	Food and Chemical Toxicology	2020
The effect of nutrients on metabolic disorders associated with polycystic ovary syndrome DV Ovcharenko, AA Popov, AA Koval, SS Tyurina, AA Fedorov	Rossiiskii vestnik akushera-ginekologa	2020
Impact of Free-Choice Diets High in Fat and Different Sugars on Metabolic Outcome and Anxiety-Like Behavior in Rats: Dietary Composition, Metabolism, and Anxiety F Peris-Sampedro, M Mounib, E Schéle, CE Edvardsson, I Stoltenborg, RA Adan, SL Dickson	Obesity	2019
Delphinidin Ameliorates Hepatic Triglyceride Accumulation in Human HepG2 Cells, but Not in Diet-Induced Obese Mice M Parra-Vargas, A Sandoval-Rodriguez, R Rodriguez-Echevarria, J Dominguez-Rosales, A Santos-Garcia, J Armendariz-Borunda	Nutrients	2018

Citations to this article

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

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Citations to this article (24)

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