Department of Obstetrics and Gynecology, Division of Reproductive Sciences, Division of Reproductive Endocrinology, Charles Gates Stem Cell Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Address correspondence to: T. Rajendra Kumar, Edgar L and Patricia M Makowski Professor, Department of Obstetrics and Gynecology, University of Colorado Anschutz Medical Campus, 12700 E. 19th Ave, 3100B, RC-2 Bldg., Aurora, Colorado 80045, USA. Phone: 303.724.8689. E-mail: email@example.com.
First published May 15, 2017 - More info
See the related article at Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.
The spermatogenesis/oogenesis helix-loop-helix (SOHLH) proteins SOHLH1 and SOHLH2 play important roles in male and female reproduction. Although previous studies indicate that these transcriptional regulators are expressed in and have in vivo roles in postnatal ovaries, their expression and function in the embryonic ovary remain largely unknown. Because oocyte differentiation is tightly coupled with the onset of meiosis, it is of significant interest to determine how early oocyte transcription factors regulate these two processes. In this issue of the
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