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Usage Information

Blood endothelial cells: utility from ambiguity
Robert P. Hebbel
Robert P. Hebbel
Published May 1, 2017
Citation Information: J Clin Invest. 2017;127(5):1613-1615. https://doi.org/10.1172/JCI93649.
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Hindsight Article has an altmetric score of 3

Blood endothelial cells: utility from ambiguity

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Abstract

In the mid-1990s, my research group began to devise a method to establish endothelial cell cultures from human peripheral blood, with an ultimate goal of examining interindividual heterogeneity of endothelial biology. The initial work, published in the JCI in 2000, described the method enabling successful attainment of blood outgrowth endothelial cells (BOEC). Truly endothelial, BOEC are progeny of a transplantable cell that originates in bone marrow, a putative endothelial progenitor. Our subsequent experimental work focused upon practical applications of BOEC: their use for gene therapy, tissue engineering, assessment of mutant gene effect, and discovery of heterogeneity in endothelial biology.

Authors

Robert P. Hebbel

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Usage data is cumulative from June 2024 through June 2025.

Usage JCI PMC
Text version 639 101
PDF 161 22
Figure 224 0
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Total Views 1,230
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