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Prevention of preeclampsia
Chad A. Grotegut
Chad A. Grotegut
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Commentary

Prevention of preeclampsia

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Abstract

Preeclampsia is a common complication of pregnancy that is associated with an increased risk of maternal and neonatal morbidity and mortality. Currently, delivery is the only cure for preeclampsia; therefore, effective prevention and treatment options for this condition are sorely needed. In the current issue of the JCI, Mirzakhani et al. report the findings of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), a well-conducted large, randomized, double-blind, placebo-controlled trial of vitamin D supplementation for the prevention of preeclampsia. Though vitamin D supplementation had no effect on the risk of preeclampsia, reduced maternal serum vitamin D levels did correlate with preeclampsia risk. Mirzakhani and colleagues identified a number of gene pathways that are differentially regulated among women with low serum vitamin D levels who develop preeclampsia. These results indicate that further research on the role of vitamin D in preeclampsia is warranted.

Authors

Chad A. Grotegut

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Usage data is cumulative from November 2025 through November 2026.

Usage JCI PMC
Text version 1,604 895
PDF 396 26
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ISSN: 0021-9738 (print), 1558-8238 (online)

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