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Citations to this article

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation
Ha-Na Lee, … , John E. Coligan, Konrad Krzewski
Ha-Na Lee, … , John E. Coligan, Konrad Krzewski
Published April 17, 2017
Citation Information: J Clin Invest. 2017;127(5):1905-1917. https://doi.org/10.1172/JCI89531.
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Research Article Immunology Inflammation Article has an altmetric score of 2

Dendritic cells expressing immunoreceptor CD300f are critical for controlling chronic gut inflammation

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Abstract

Proinflammatory cytokine overproduction and excessive cell death, coupled with impaired clearance of apoptotic cells, have been implicated as causes of failure to resolve gut inflammation in inflammatory bowel diseases. Here we have found that dendritic cells expressing the apoptotic cell–recognizing receptor CD300f play a crucial role in regulating gut inflammatory responses in a murine model of colonic inflammation. CD300f-deficient mice failed to resolve dextran sulfate sodium–induced colonic inflammation as a result of defects in dendritic cell function that were associated with abnormal accumulation of apoptotic cells in the gut. CD300f-deficient dendritic cells displayed hyperactive phagocytosis of apoptotic cells, which stimulated excessive TNF-α secretion predominantly from dendritic cells. This, in turn, induced secondary IFN-γ overproduction by colonic T cells, leading to prolonged gut inflammation. Our data highlight a previously unappreciated role for dendritic cells in controlling gut homeostasis and show that CD300f-dependent regulation of apoptotic cell uptake is essential for suppressing overactive dendritic cell–mediated inflammatory responses, thereby controlling the development of chronic gut inflammation.

Authors

Ha-Na Lee, Linjie Tian, Nicolas Bouladoux, Jacquice Davis, Mariam Quinones, Yasmine Belkaid, John E. Coligan, Konrad Krzewski

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Total citations by year

Year: 2025 2024 2023 2022 2020 2019 2001 Total
Citations: 4 3 1 3 2 1 1 15
Citation information
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Citations to this article in year 2022 (3)

Title and authors Publication Year
Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization
S Gwak, S Kim, J Park, S Kim, Y Joe, H Lee, W Kim, I Muna, H Na, H Chung, Y Surh
Gut and Liver 2022
Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease.
Yang WS, Wang JL, Wu W, Wang GF, Yan J, Liu Q, Wu XY, Zhou QT, Yang DH, Wang MW, Li ZP
Acta Pharmacologica Sinica 2022
Pan‐cancer analysis identifies CD300 molecules as potential immune regulators and promising therapeutic targets in acute myeloid leukemia
Xu Z, Jin Y, Zhang X, Xia P, Wen X, Ma J, Lin J, Qian J
Cancer Medicine 2022

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