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Citations to this article

CKAP4 is identified as a receptor for Dickkopf in cancer cells
Dheeraj Bhavanasi, … , Kelsey F. Speer, Peter S. Klein
Dheeraj Bhavanasi, … , Kelsey F. Speer, Peter S. Klein
Published June 20, 2016
Citation Information: J Clin Invest. 2016;126(7):2419-2421. https://doi.org/10.1172/JCI88620.
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Commentary Article has an altmetric score of 14

CKAP4 is identified as a receptor for Dickkopf in cancer cells

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Abstract

The secretory protein Dickkopf-1 (DKK-1) is a known Wnt antagonist and has been shown to suppress tumorigenesis in some cancer cells; however, it is also upregulated in many types of cancer and associated with poor prognosis. Wnt-independent mechanisms by which DKK-1 promotes cancer cell proliferation are not well understood. In this issue of the JCI, Kimura and colleagues demonstrate that DKK-1 interacts with cytoskeleton-associated protein 4 (CKAP4) to promote activation of AKT. They show that both DKK-1 and CKAP4 are frequently upregulated in pancreatic and lung cancers. Importantly, targeting this interaction with an anti-CKAP4 antibody prevented tumor formation in murine xenograft models. These results identify a previously unrecognized DKK-1–mediated pathway and suggest CKAP4 as a potential therapeutic target for certain cancers.

Authors

Dheeraj Bhavanasi, Kelsey F. Speer, Peter S. Klein

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2009 Total
Citations: 4 3 4 4 4 2 1 2 1 1 26
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (1)

Title and authors Publication Year
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling
C Sun, J Geng, Y Yan, X Yao, M Liu
Journal of Cancer 2017

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