The secretory protein Dickkopf-1 (DKK-1) is a known Wnt antagonist and has been shown to suppress tumorigenesis in some cancer cells; however, it is also upregulated in many types of cancer and associated with poor prognosis. Wnt-independent mechanisms by which DKK-1 promotes cancer cell proliferation are not well understood. In this issue of the
Dheeraj Bhavanasi, Kelsey F. Speer, Peter S. Klein
Title and authors | Publication | Year |
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Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling
C Sun, J Geng, Y Yan, X Yao, M Liu |
Journal of Cancer | 2017 |