The secretory protein Dickkopf-1 (DKK-1) is a known Wnt antagonist and has been shown to suppress tumorigenesis in some cancer cells; however, it is also upregulated in many types of cancer and associated with poor prognosis. Wnt-independent mechanisms by which DKK-1 promotes cancer cell proliferation are not well understood. In this issue of the
Dheeraj Bhavanasi, Kelsey F. Speer, Peter S. Klein
Title and authors | Publication | Year |
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DKK1 and Its Receptors in Esophageal Adenocarcinoma: A Promising Molecular Target
Despotidis M, Lyros O, Driva TS, Sarantis P, Kapetanakis EI, Mylonakis A, Mamilos A, Sakellariou S, Schizas D |
Diagnostics | 2025 |
Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma
Haskell A, Pan S, Reese R, Powers A, Lopez MG, Lomeli S, Story C, Benton J, Blazier JC, Kaunas R, Gregory CA |
Scientific Reports | 2025 |
Parvimonas micra promotes oral squamous cell carcinoma metastasis through TmpC-CKAP4 axis
Qi H, Gao H, Li M, Sun T, Gu X, Wei L, Zhi M, Li Z, Fu D, Liu Y, Wei Z, Dou Y, Feng Q |
Nature Communications | 2025 |
Threading the Needle: Navigating Novel Immunotherapeutics in Pancreatic Ductal Adenocarcinoma
Demir T, Moloney C, Mahalingam D |
Cancers | 2025 |
Immunohistochemical and Morphometric Assessment on the Biological Function and Vascular Endothelial Cells in the Initial Process of Cortical Porosity in Mice With PTH Administration
Abe M, Hasegawa T, Hongo H, Yamamoto T, Shi Y, Cui J, Liu X, Yao Q, Ishizu H, Maruoka H, Yoshino H, Haraguchi-Kitakamae M, Shimizu T, Amizuka N |
Journal of Histochemistry & Cytochemistry | 2024 |
The Role of Serum Dickkopf1 and CKAP4 Levels in Diagnosing Colorectal Cancer and Measuring the Disease Severity: A Prospective Study
Dişçi E, Peksöz R, Laloğlu E, Yıldırgan Mİ, Albayrak Y, Şirin MA, Ağırman E, Atamanalp SS |
Medicina | 2024 |
DKK1 as a chemoresistant protein modulates oxaliplatin responses in colorectal cancer
Hsieh CC, Li TW, Li CC, Chen SH, Wei YL, Chiang NJ, Shen CH |
Oncogenesis | 2024 |
Postoperative recurrence of mixed extragonadal germ cell tumor in the right shoulder: a case report
Li Y, Huang X, Meng X, Luo Y, Luo S, Wang J |
Diagnostic Pathology | 2023 |
Factors affecting the role of canonical Wnt inhibitor Dickkopf-1 in cancer progression
Doucet D, Brubaker C, Turner D, Gregory CA |
Frontiers in Oncology | 2023 |
Dickkopf-1 Acts as a Profibrotic Mediator in Progressive Chronic Kidney Disease
Hsu YC, Chang CC, Hsieh CC, Huang YT, Shih YH, Chang HC, Chang PJ, Lin CL |
International journal of molecular sciences | 2023 |
The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development, Immune Modulation and Cancer.
Mourtada J, Thibaudeau C, Wasylyk B, Jung AC |
Cells | 2023 |
Drug Discovery of DKK1 Inhibitors
H Jiang, Z Zhang, Y Yu, H Chu, S Yu, S Yao, G Zhang, B Zhang |
Frontiers in pharmacology | 2022 |
Generation of An Induced Pluripotent Stem Cell Line from Human Liver Fibroblasts from A Patient with Combined Hepatocellular-Cholangiocarcinoma
HyoSuk Ahn, JaeSung Ryu, Jaeseo Lee, Seon Ju Mun, YeonHwa Hong, Yongbo Shin, KyungSook Chung, Myung Jin Son |
Cell Journal (Yakhteh) | 2022 |
Dickkopf1 fuels inflammatory cytokine responses
Jaschke NP, Pählig S, Sinha A, Adolph TE, Colunga ML, Hofmann M, Wang A, Thiele S, Schwärzler J, Kleymann A, Gentzel M, Tilg H, Wielockx B, Hofbauer LC, Rauner M, Göbel A, Rachner TD |
Communications biology | 2022 |
Dickkopf-related protein 1/cytoskeleton-associated protein 4 signaling activation by Helicobacter pylori-induced activator protein-1 promotes gastric tumorigenesis via the PI3K/AKT/mTOR pathway
Luo M, Chen YJ, Xie Y, Wang QR, Xiang YN, Long NY, Yang WX, Zhao Y, Zhou JJ |
World Journal of Gastroenterology | 2022 |
DKK1 activates noncanonical NF-κB signaling via IL-6–induced CKAP4 receptor in multiple myeloma
X Li, J Wang, S Zhu, J Zheng, Y Xie, H Jiang, J Guo, Y Wang, Z Peng, M Wang, J Wang, S Wang, Y Zhong, Z Liu |
Blood Advances | 2021 |
Cytoskeleton-Associated Protein 4, a Promising Biomarker for Tumor Diagnosis and Therapy
SX Li, J Li, LW Dong, ZY Guo |
Frontiers in Molecular Biosciences | 2021 |
Cytoskeleton-associated protein 4 (CKAP4) promotes malignant progression of human gliomas through inhibition of the Hippo signaling pathway
T Luo, K Ding, J Ji, X Zhang, X Yang, A Chen, B Huang, D Zhang, J Wang, X Li |
Journal of Neuro-Oncology | 2021 |
Importance of WNT-dependent signaling for derivation and maintenance of primed pluripotent bovine embryonic stem cells
Y Xiao, TF Amaral, PJ Ross, DA Soto, KE Diffenderfer, AR Pankonin, S Jeensuk, P Tríbulo, PJ Hansen |
Biology of reproduction | 2021 |
Balanced Wnt/Dickkopf1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function
ME Summers, BW Richmond, JA Kropski, SA Majka, JA Bastarache, AK Hatzopoulos, J Bylund, M Ghosh, I Petrache, RF Foronjy, P Geraghty, SM Majka |
American journal of physiology. Cell physiology | 2020 |
Comprehending Meningioma Signaling Cascades Using Multipronged Proteomics Approaches & Targeted Validation of Potential Markers
S Mukherjee, D Biswas, R Gadre, P Jain, N Syed, J Stylianou, Q Zeng, A Mahadevan, S Epari, P Shetty, A Moiyadi, GR Ball, S Srivastava |
Frontiers in Oncology | 2020 |
Screening differentially expressed proteins from co-cultured hematopoietic cells and bone marrow-derived stromal cells by quantitative proteomics (SILAC) method
R Liu, Y Wang, B Li, H Wang, F Guan, Z Tan, X Li |
Clinical Proteomics | 2019 |
TMEM59 potentiates Wnt signaling by promoting signalosome formation
JP Gerlach, I Jordens, DV Tauriello, I van t Land-Kuper, JM Bugter, I Noordstra, J van der Kooij, TY Low, FX Pimentel-Muiños, D Xanthakis, N Fenderico, C Rabouille, AJ Heck, DA Egan, MM Maurice |
Proceedings of the National Academy of Sciences | 2018 |
Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism
J Dunn, S Ferluga, V Sharma, M Futschik, DA Hilton, CL Adams, E Lasonder, OC Hannemann |
EBioMedicine | 2018 |
Overexpression of CKAP4 is Associated with Poor Prognosis in Clear Cell Renal Cell Carcinoma and Functions via Cyclin B Signaling
C Sun, J Geng, Y Yan, X Yao, M Liu |
Journal of Cancer | 2017 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |