Rapid impulse propagation in the heart is a defining property of pectinated atrial myocardium (PAM) and the ventricular conduction system (VCS) and is essential for maintaining normal cardiac rhythm and optimal cardiac output. Conduction defects in these tissues produce a disproportionate burden of arrhythmic disease and are major predictors of mortality in heart failure patients. Despite the clinical importance, little is known about the gene regulatory network that dictates the fast conduction phenotype. Here, we have used signal transduction and transcriptional profiling screens to identify a genetic pathway that converges on the NRG1-responsive transcription factor ETV1 as a critical regulator of fast conduction physiology for PAM and VCS cardiomyocytes.
Akshay Shekhar, Xianming Lin, Fang-Yu Liu, Jie Zhang, Huan Mo, Lisa Bastarache, Joshua C. Denny, Nancy J. Cox, Mario Delmar, Dan M. Roden, Glenn I. Fishman, David S. Park
Title and authors | Publication | Year |
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Defects in Trabecular Development Contribute to Left Ventricular Noncompaction
C Choquet, RG Kelly, L Miquerol |
Pediatric Cardiology | 2019 |
Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution
WR Goodyer, BM Beyersdorf, DT Paik, L Tian, G Li, JW Buikema, O Chirikian, S Choi, S Venkatraman, EL Adams, M Tessier-Lavigne, JC Wu, SM Wu |
Circulation research | 2019 |
Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis
Y Liu, P Lu, Y Wang, BE Morrow, B Zhou, D Zheng |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2019 |