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Citations to this article

Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis
Graig C. Suvannavejh, … , Louis A. Matis, Stephen D. Miller
Graig C. Suvannavejh, … , Louis A. Matis, Stephen D. Miller
Published January 15, 2000
Citation Information: J Clin Invest. 2000;105(2):223-231. https://doi.org/10.1172/JCI8561.
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Article

Fas-mediated apoptosis in clinical remissions of relapsing experimental autoimmune encephalomyelitis

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Abstract

PLP139-51–induced experimental autoimmune encephalomyelitis (R-EAE) displays a relapsing-remitting paralytic course in female SJL mice. We investigated the role of apoptosis/activation-induced cell death (AICD) in the spontaneous recovery from acute disease. Clinical EAE was significantly enhanced in Fas (CD95/APO-1)–deficient SJL lpr/lpr mice, which displayed significantly increased mean peak clinical scores, reduced remission rates, and increased mortality when compared with their SJL +/lpr littermates. PLP139-151–specific proliferative responses were fairly equivalent in the 2 groups, but draining lymph node T cells from SJL lpr/lpr mice produced dramatically increased levels of IFN-γ. Central nervous system (CNS) Fas and FasL mRNA levels in wild-type SJL (H-2s) mice peaked just before spontaneous disease remission and gradually declined as disease remitted. We applied the terminal deoxynucleotidyl transferase–mediated dUTP nick-end labeling (TUNEL) assay to detect apoptosis in situ in spinal cords of mice at various clinical stages of EAE. Most TUNEL+ cells were found during active periods of inflammation: the acute, peak, and relapse time points. Significantly fewer apoptotic cells were observed at preclinical and remission time points. Collectively, these findings indicate that Fas-mediated apoptosis/AICD plays a major role in the spontaneous remission after the initial acute inflammatory episode and represents an important intrinsic mechanism in regulation of autoimmune responses.

Authors

Graig C. Suvannavejh, Mauro C. Dal Canto, Louis A. Matis, Stephen D. Miller

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Citations to this article (117)

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Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients.
Alghamdi M, Al-Eitan L, Aljamal H, Abu Kharmah H
Medicina (Kaunas, Lithuania) 2024
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L
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N Feizi, C Focaccetti, I Pacella, G Tucci, A Rossi, M Costanza, R Pedotti, J Sidney, A Sette, CL Rocca, C Procaccini, G Matarese, V Barnaba, S Piconese
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F Anselmo, A Tatomir, D Boodhoo, AP Mekala, V Nguyen, V Rus, H Rus
Clinical Immunology 2020
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R Bhat, S Mahapatra, RC Axtell, L Steinman
Journal of Neuroimmunology 2017
Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic
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Inflammation - From Molecular and Cellular Mechanisms to the Clinic: From Molecular and Cellular Mechanisms to the Clinic 2017
Effects of Tripterygium glycoside treatment on experimental autoimmune encephalomyelitis
J Qiu, X You, G Wu
Molecular medicine reports 2017
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S Sonar
Frontiers in immunology 2015
Control of the Survival and Growth of Human Glioblastoma Grafted into the Spinal Cord of Mice by Taking Advantage of Immunorejection
G Itakura, Y Kobayashi, S Nishimura, H Iwai, M Takano, A Iwanami, Y Toyama, H Okano, M Nakamura
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Constitutive expression of murine c-FLIPR causes autoimmunity in aged mice
F Ewald, M Annemann, MC Pils, C Plaza-Sirvent, F Neff, C Erck, D Reinhold, I Schmitz
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SM Tietz, R Hofmann, T Thomas, B Tackenberg, M Gaestel, M Berghoff
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Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis
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ME Turvey, T Koudelka, I Comerford, JM Greer, W Carroll, CC Bernard, P Hoffmann, SR McColl
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MK2 and Fas Receptor Contribute to the Severity of CNS Demyelination
SM Tietz, R Hofmann, T Thomas, B Tackenberg, M Gaestel, M Berghoff, RA Linker
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Promotion and prevention of autoimmune disease by CD8+ T cells
DM Gravano, KK Hoyer
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CA Tegla, CD Cudrici, P Azimzadeh, AK Singh, R Trippe, A Khan, H Chen, M Andrian-Albescu, W Royal, C Bever, V Rus, H Rus
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Antigen-Specific CD25−Foxp3−IFN-γhighCD4+ T Cells Restrain the Development of Experimental Allergic Encephalomyelitis by Suppressing Th17
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2009
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2009
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Therapeutic Targets of the TNF Superfamily
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Resistance to activation-induced cell death and elevated FLIPL expression of CD4+ T cells in a polyI:C-induced primary biliary cirrhosis mouse model
T Jiang, Z Han, S Chen, C Wu, Y Tang, C Qian, Y Chen, Y Zhou, Y Zhu, M Gu, L Zhu, D Yao, A Deng, R Zhong
Clinical and Experimental Medicine 2009
Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death
G Shi, M Ramaswamy, BP Vistica, CA Cox, C Tan, EF Wawrousek, RM Siegel, I Gery
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Immunomodulation of EAE by alpha-fetoprotein involves elevation of immune cell apoptosis markers and the transcription factor FoxP3
M Irony-Tur-Sinai, N Grigoriadis, D Tsiantoulas, O Touloumi, O Abramsky, T Brenner
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Rheumatoid Arthritis 2009
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Cultured Murine Thyroid Epithelial Cells Expressing Transgenic Fas-Associated Death Domain-Like Interleukin-1β Converting Enzyme Inhibitory Protein Are Protected from Fas-Mediated Apoptosis
Y Fang, H Braley-Mullen
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A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE
Menezes JS, van den Elzen P, Thornes J, Huffman D, Droin N, Maverakis E, Sercarz, EE
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Experimental Models of Multiple Sclerosis
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Apoptosis in Health and Disease: Clinical and Therapeutic Aspects
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Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses
C Choi, EN Benveniste
Brain Research Reviews 2004
CD95 polymorphisms are associated with susceptibility to MS in women
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Fas Ligand Is Required for Resolution of Granulomatous Experimental Autoimmune Thyroiditis
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GX Zhang, B Gran, S Yu, J Li, I Siglienti, X Chen, M Kamoun, A Rostami
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LYMPHOCYTE-MEDIATEDCYTOTOXICITY
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CELL DEATH AND IMMUNE PRIVILEGE
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S Terrazzino, A Bauleo, A Baldan, A Leon
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B Zhu, L Luo, Y Chen, DW Paty, MS Cynader
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E Ciusani, M Gelati, S Frigerio, B Pollo, G Massa, P Sacerdote, AE Panerai, A Salmaggi
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C Nohara, H Akiba, A Nakajima, A Inoue, CS Koh, H Ohshima, H Yagita, Y Mizuno, K Okumura
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S Issazadeh, K Abdallah, T Chitnis, A Chandraker, AD Wells, LA Turka, MH Sayegh, SJ Khoury
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Y Okuda, S Sakoda, H Fujimura, S Nagata, T Yanagihara, CC Bernard
Biochemical and Biophysical Research Communications 2000
The role of Fas ligand in vivo as a cause and regulator of pathogenesis
KA Sabelko-Downes, JH Russell
Current Opinion in Immunology 2000
Increased cellular expression of the caspase inhibitor FLIP in intrathecal lymphocytes from patients with multiple sclerosis
MK Sharief
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GC Suvannavejh, HO Lee, J Padilla, MC Canto, TA Barrett, SD Miller
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CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis
N J Karandikar, T N Eagar, C L Vanderlugt, J A Bluestone, S D Miller
Journal of Neuroimmunology 2000
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RM Siegel, FK Chan, HJ Chun, MJ Lenardo
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Acceleration of spontaneous diabetes in TCR-beta-transgenic nonobese diabetic mice by beta-cell cytotoxic CD8+ T cells expressing identical endogenous TCR-alpha chains
P Santamaria
Journal of immunology (Baltimore, Md. : 1950) 1996
Autoimmunity
AJ King, SA Schwartz, DE Lopatin, JJ Voorhees, LA Diaz
International Journal of Dermatology 1981

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