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Citations to this article

MicroRNA regulation of lymphocyte tolerance and autoimmunity
Laura J. Simpson, K. Mark Ansel
Laura J. Simpson, K. Mark Ansel
Published June 1, 2015
Citation Information: J Clin Invest. 2015;125(6):2242-2249. https://doi.org/10.1172/JCI78090.
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Review Series Article has an altmetric score of 4

MicroRNA regulation of lymphocyte tolerance and autoimmunity

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Abstract

Understanding the cell-intrinsic cues that permit self-reactivity in lymphocytes, and therefore autoimmunity, requires an understanding of the transcriptional and posttranscriptional regulation of gene expression in these cells. In this Review, we address seminal and recent research on microRNA (miRNA) regulation of central and peripheral tolerance. Human and mouse studies demonstrate that the PI3K pathway is a critical point of miRNA regulation of immune cell development and function that affects the development of autoimmunity. We also discuss how miRNA expression profiling in human autoimmune diseases has inspired mechanistic studies of miRNA function in the pathogenesis of multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes, and asthma.

Authors

Laura J. Simpson, K. Mark Ansel

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 1 1 7 2 3 2 2 7 7 11 3 46
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2019 (2)

Title and authors Publication Year
The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity
MG Scherm, I Serr, KH Kaestner, C Daniel
Molecular Metabolism 2019
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
MG Scherm, I Serr, AM Zahm, J Schug, S Bellusci, R Manfredini, VK Salb, K Gerlach, B Weigmann, AG Ziegler, KH Kaestner, C Daniel
Nature Communications 2019

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ISSN: 0021-9738 (print), 1558-8238 (online)

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