The mTOR pathway orchestrates diverse physiological processes, including T cell functions and fate decisions; however, the regulation of mTOR-dependent T cell differentiation remains elusive. In this issue, Park et al. examine the role of TSC1, an mTOR signaling regulator, in T cell differentiation and the balance between T cell–mediated immunity and tolerance. They found that enhanced mTOR activity in
Kai Yang, Hongbo Chi
Schematics of mTOR signaling.