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Citations to this article

AKT activation promotes PTEN hamartoma tumor syndrome–associated cataract development
Caterina Sellitto, … , Richard T. Mathias, Thomas W. White
Caterina Sellitto, … , Richard T. Mathias, Thomas W. White
Published November 25, 2013
Citation Information: J Clin Invest. 2013;123(12):5401-5409. https://doi.org/10.1172/JCI70437.
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Research Article Ophthalmology Article has an altmetric score of 11

AKT activation promotes PTEN hamartoma tumor syndrome–associated cataract development

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Abstract

Mutations in the human phosphatase and tensin homolog (PTEN) gene cause PTEN hamartoma tumor syndrome (PHTS), which includes cataract development among its diverse clinical pathologies. Currently, it is not known whether cataract formation in PHTS patients is secondary to other systemic problems, or the result of the loss of a critical function of PTEN within the lens. We generated a mouse line with a lens-specific deletion of Pten (PTEN KO) and identified a regulatory function for PTEN in lens ion transport. Specific loss of PTEN in the lens resulted in cataract. PTEN KO lenses exhibited a progressive age-related increase in intracellular hydrostatic pressure, along with, increased intracellular sodium concentrations, and reduced Na+/K+-ATPase activity. Collectively, these defects lead to lens swelling, opacities and ultimately organ rupture. Activation of AKT was highly elevated in PTEN KO lenses compared to WT mice. Additionally, pharmacological inhibition of AKT restored normal Na+/K+-ATPase activity in primary cultured lens cells and reduced lens pressure in intact lenses from PTEN KO animals. These findings identify a direct role for PTEN in the regulation of lens ion transport through an AKT-dependent modulation of Na+/K+-ATPase activity, and provide a new animal model to investigate cataract development in PHTS patients.

Authors

Caterina Sellitto, Leping Li, Junyuan Gao, Michael L. Robinson, Richard Z. Lin, Richard T. Mathias, Thomas W. White

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Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 1 1 2 2 4 3 3 3 2 3 24
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2015 (3)

Title and authors Publication Year
Differential regulation of Connexin50 and Connexin46 by PI3K signaling
JM Martinez, HZ Wang, RZ Lin, PR Brink, TW White
FEBS Letters 2015
Feedback Regulation of Intracellular Hydrostatic Pressure in Surface Cells of the Lens
J Gao, X Sun, TW White, NA Delamere, RT Mathias
Biophysical Journal 2015
Germline activating MTOR mutation arising through gonadal mosaicism in two brothers with megalencephaly and neurodevelopmental abnormalities
C Mroske, K Rasmussen, DN Shinde, R Huether, Z Powis, HM Lu, RM Baxter, E McPherson, S Tang
BMC Medical Genetics 2015

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ISSN: 0021-9738 (print), 1558-8238 (online)

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