Advertisement
C/EBPγ deregulation results in differentiation arrest in acute myeloid leukemia
Meritxell Alberich-Jordà, Bas Wouters, Martin Balastik, Clara Shapiro-Koss, Hong Zhang, Annalisa Di Ruscio, Hanna S. Radomska, Alexander K. Ebralidze, Giovanni Amabile, Min Ye, Junyan Zhang, Irene Lowers, Roberto Avellino, Ari Melnick, Maria E. Figueroa, Peter J.M. Valk, Ruud Delwel, and Daniel G. Tenen
Find articles by Alberich-Jordà, M. in: PubMed | Google Scholar
Find articles by Wouters, B. in: PubMed | Google Scholar
Find articles by Balastik, M. in: PubMed | Google Scholar
Find articles by Shapiro-Koss, C. in: PubMed | Google Scholar
Find articles by Zhang, H. in: PubMed | Google Scholar
Find articles by Di Ruscio, A. in: PubMed | Google Scholar
Find articles by Radomska, H. in: PubMed | Google Scholar
Find articles by Ebralidze, A. in: PubMed | Google Scholar
Find articles by Amabile, G. in: PubMed | Google Scholar
Find articles by Ye, M. in: PubMed | Google Scholar
Find articles by Zhang, J. in: PubMed | Google Scholar
Find articles by Lowers, I. in: PubMed | Google Scholar
Find articles by Avellino, R. in: PubMed | Google Scholar
Find articles by Melnick, A. in: PubMed | Google Scholar
Find articles by Figueroa, M. in: PubMed | Google Scholar
Find articles by Valk, P. in: PubMed | Google Scholar
Find articles by Delwel, R. in: PubMed | Google Scholar
Find articles by Tenen, D. in: PubMed | Google Scholar
Published January 2, 2013 - More info
J Clin Invest. 2013;123(1):526–526. https://doi.org/10.1172/JCI68299.
© 2013 The American Society for Clinical Investigation
Related article:
Abstract
C/EBPs are a family of transcription factors that regulate growth control and differentiation of various tissues. We found that C/EBPγ is highly upregulated in a subset of acute myeloid leukemia (AML) samples characterized by C/EBPα hypermethylation/silencing. Similarly, C/EBPγ was upregulated in murine hematopoietic stem/progenitor cells lacking C/EBPα, as C/EBPα mediates C/EBPγ suppression. Studies in myeloid cells demonstrated that CEBPG overexpression blocked neutrophilic differentiation. Further, downregulation of Cebpg in murine Cebpa-deficient stem/progenitor cells or in human CEBPA-silenced AML samples restored granulocytic differentiation. In addition, treatment of these leukemias with demethylating agents restored the C/EBPα-C/EBPγ balance and upregulated the expression of myeloid differentiation markers. Our results indicate that C/EBPγ mediates the myeloid differentiation arrest induced by C/EBPα deficiency and that targeting the C/EBPα-C/EBPγ axis rescues neutrophilic differentiation in this unique subset of AMLs.
Authors
Meritxell Alberich-Jordà, Bas Wouters, Martin Balastik, Clara Shapiro-Koss, Hong Zhang, Annalisa DiRuscio, Hanna S. Radomska, Alexander K. Ebralidze, Giovanni Amabile, Min Ye, Junyan Zhang, Irene Lowers, Roberto Avellino, Ari Melnick, Maria E. Figueroa, Peter J.M. Valk, Ruud Delwel, Daniel G. Tenen
Original citation: J. Clin. Invest. 2012;122(12):4490–4504. doi:10.1172/JCI65102.
Citation for this corrigendum: J. Clin. Invest. 2013;123(1):526. doi:10.1172/JCI68299.
In the author list, Annalisa Di Ruscio’s name was spelled incorrectly. The correct author list is above.
The authors regret the error.
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)