Recent advances in developmental biology have greatly expanded our understanding of progenitor cell programming and the fundamental roles that Sox9 plays in liver and pancreas organogenesis. In the last 2 years, several studies have dissected the behavior of the Sox9+ duct cells in adult organs, but conflicting results have left unanswered the long-standing question of whether physiologically functioning progenitors exist in adult liver and pancreas. On the other hand, increasing evidence suggests that duct cells function as progenitors in the tissue restoration process after injury, during which embryonic programs are sometimes reactivated. This article discusses the role of Sox9 in programming liver and pancreatic progenitors as well as controversies in the field.
Yoshiya Kawaguchi
Title and authors | Publication | Year |
---|---|---|
Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo
DH Balani, HM Kronenberg |
Bone | 2018 |
Calcium Signaling in Liver Injury and Regeneration
N Oliva-Vilarnau, S Hankeova, SU Vorrink, S Mkrtchian, ER Andersson, VM Lauschke |
Frontiers in Medicine | 2018 |
Modeling human pancreatic beta cell dedifferentiation
M Diedisheim, M Oshima, O Albagli, CW Huldt, I Ahlstedt, M Clausen, S Menon, A Aivazidis, AC Andreasson, WG Haynes, P Marchetti, L Marselli, M Armanet, F Chimienti, R Scharfmann |
Molecular Metabolism | 2018 |
SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
X Yuan, J Li, C Coulouarn, T Lin, L Sulpice, D Bergeat, CD Torre, R Liebe, N Gretz, MP Ebert, S Dooley, HL Weng |
British Journal of Cancer | 2018 |