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Yoshiya Kawaguchi
Published May 1, 2013
Citation Information: J Clin Invest. 2013;123(5):1881-1886. https://doi.org/10.1172/JCI66022.
Citation Information: J Clin Invest. 2013;123(5):1881-1886. https://doi.org/10.1172/JCI66022.
Abstract
Recent advances in developmental biology have greatly expanded our understanding of progenitor cell programming and the fundamental roles that Sox9 plays in liver and pancreas organogenesis. In the last 2 years, several studies have dissected the behavior of the Sox9+ duct cells in adult organs, but conflicting results have left unanswered the long-standing question of whether physiologically functioning progenitors exist in adult liver and pancreas. On the other hand, increasing evidence suggests that duct cells function as progenitors in the tissue restoration process after injury, during which embryonic programs are sometimes reactivated. This article discusses the role of Sox9 in programming liver and pancreatic progenitors as well as controversies in the field.
Authors
Yoshiya Kawaguchi
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Citations to this article (53)
| Title and authors | Publication | Year |
|---|---|---|
|
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Frontiers in Genetics | 2024 |
|
Cell competition promotes metastatic intestinal cancer through a multistage process.
Krotenberg Garcia A, Ledesma-Terrón M, Lamprou M, Vriend J, van Luyk ME, Suijkerbuijk SJE |
iScience | 2024 |
|
Sox9: A potential regulator of cancer stem cells in osteosarcoma
Li X, Lv Z, Zhou P, Zhang S, Jiang C |
Open Medicine | 2024 |
|
Transcriptional Control: A Directional Sign at the Crossroads of Adult Hepatic Progenitor Cells' Fates
Xu C, Fang X, Song Y, Xiang Z, Xu X, Wei X |
International journal of biological sciences | 2024 |
|
SOX9 Overexpression Ameliorates Metabolic Dysfunction-associated Steatohepatitis Through Activation of the AMPK Pathway
Deng J, Ding K, Liu S, Chen F, Huang R, Xu B, Zhang X, Xie W |
Journal of Clinical and Translational Hepatology | 2024 |
|
Heterogeneity of Islet Cells during Embryogenesis and Differentiation.
Sasaki S, Miyatsuka T |
Diabetes & Metabolism Journal | 2023 |
|
Significance of CCNs in liver regeneration.
Barkin JM, Jin-Smith B, Torok K, Pi L |
Journal of Cell Communication and Signaling | 2023 |
|
Bavachinin protects the liver in NAFLD by promoting regeneration via targeting PCNA.
Dong X, Lu S, Tian Y, Ma H, Wang Y, Zhang X, Sun G, Luo Y, Sun X |
Journal of Advanced Research | 2023 |
|
Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease
J Hallett, S Ferreira-Gonzalez, T Man, A Kilpatrick, H Esser, K Thirlwell, M Macmillan, D Rodrigo-Torres, B Dwyer, V Gadd, C Ashmore-Harris, W Lu, J Thomson, M Jansen, E ODuibhir, P Lewis, L Campana, R Aird, T Bate, A Fraser, J Campbell, G Oniscu, D Hay, A Callanan, S Forbes |
Cell Stem Cell | 2022 |
|
Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin
Y Zhang, L Li, Y Zhang, S Yan, L Huang, R Calafiore |
Journal of Diabetes Research | 2022 |
|
Expression and Potential Prognostic Value of SOX9, MCL-1 and SPOCK1 in Gastric Adenocarcinoma
W Luo, T Nagaria, H Sun, J Ma, J Lombardo, R Bassett, A Cao, D Tan |
Pathology oncology research : POR | 2022 |
|
Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway.
Liu Z, Liu J, Chen T, Wang Y, Shi A, Li K, Li X, Qiu B, Zheng L, Zhao L, Shu L, Lian S, Huang S, Zhang Z, Xu Y |
Oncogene | 2022 |
|
Up-regulation of sex-determining region Y-box 9 (SOX9) in growth hormone-secreting pituitary adenomas
FI Shirian, M Ghorbani, ME Khamseh, M Imani, M Panahi, A Alimohammadi, M Nourbakhsh, V Salimi, M Tavakoli-Yaraki |
BMC Endocrine Disorders | 2021 |
|
SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer
J Li, X Chen, L Zhu, Z Lao, T Zhou, L Zang, W Ge, M Jiang, J Xu, Y Cao, S Du, Y Yu, G Fan, H Wang |
Oncogene | 2021 |
|
New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells
R Dettmer, I Niwolik, I Mehmeti, A Jörns, O Naujok |
Stem Cell Reviews and Reports | 2021 |
|
Identification of key genes and pathways in mild and severe nonalcoholic fatty liver disease by integrative analysis
J Feng, T Wei, X Cui, R Wei, T Hong |
Chronic Diseases and Translational Medicine | 2021 |
|
Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis
Jeongeun Hyun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas V. Chembazhi, Kuo Du, Tianyi Chen, Hidekazu Tsukamoto, Ivan Rusyn, Auinash Kalsotra, Anna Mae Diehl |
Journal of Clinical Investigation | 2020 |
|
A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury
JY Kim, Y Bai, LA Jayne, RD Hector, AK Persaud, SS Ong, S Rojesh, R Raj, MJ Feng, S Chung, RE Cianciolo, JW Christman, MJ Campbell, DS Gardner, SD Baker, A Sparreboom, R Govindarajan, H Singh, T Chen, M Poi, K Susztak, SR Cobb, NS Pabla |
Nature Communications | 2020 |
|
MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity
E Liang, Y Lu, Y Shi, Q Zhou, F Zhi |
Oncogene | 2020 |
|
SOX9 promotes tumor progression through the axis BMI1-p21CIP
P Aldaz, M Otaegi-Ugartemendia, A Saenz-Antoñanzas, M Garcia-Puga, M Moreno-Valladares, JM Flores, D Gerovska, MJ Arauzo-Bravo, N Samprón, A Matheu, E Carrasco-Garcia |
Scientific Reports | 2020 |
|
Real‐time fluorometric evaluation of hepatoblast proliferation in vivo and in vitro using the expression of CYP3A7 coding for human fetus‐specific P450
S Okuyama, F Kawamura, M Kubiura, S Tsuji, M Osaki, H Kugoh, M Oshimura, Y Kazuki, M Tada |
Pharmacology Research & Perspectives | 2020 |
|
DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis
E Iguchi, A Takai, H Takeda, K Kumagai, S Arasawa, Y Eso, T Shimizu, Y Ueda, H Marusawa, H Seno |
Scientific Reports | 2020 |
|
Epigenetic silencing of AATK in acinar to ductal metaplasia in murine model of pancreatic cancer
LY Ding, YC Hou, IY Kuo, TY Hsu, TC Tsai, HW Chang, WY Hsu, CC Tsao, CC Tian, PS Wang, HC Wang, CT Lee, YC Wang, SH Lin, MW Hughes, WJ Chuang, PJ Lu, YS Shan, PH Huang |
Clinical Epigenetics | 2020 |
|
The local and circulating SOX9 as a potential biomarker for the diagnosis of primary bone cancer
A Hosseini, A Mirzaei, V Salimi, K Jamshidi, P Babaheidarian, S Fallah, Z Rampisheh, N Khademian, Z Abdolvahabi, M Bahrabadi, M Ibrahimi, F Hosami, M Tavakoli-Yaraki |
Journal of Bone Oncology | 2020 |
|
SOX9 Stem-Cell Factor: Clinical and Functional Relevance in Cancer
M Aguilar-Medina, M Avendaño-Félix, E Lizárraga-Verdugo, M Bermúdez, JG Romero-Quintana, R Ramos-Payan, E Ruíz-García, C López-Camarillo |
Journal of Oncology | 2019 |
|
Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis
Y Nishikawa, Y Kodama, M Shiokawa, T Matsumori, S Marui, K Kuriyama, T Kuwada, Y Sogabe, N Kakiuchi, T Tomono, A Mima, T Morita, T Ueda, M Tsuda, Y Yamauchi, Y Sakuma, Y Ota, T Maruno, N Uza, M Uesugi, R Kageyama, T Chiba, H Seno |
Oncogene | 2019 |
|
Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
Giancotti, Monti, Nevi, Brunelli, Pajno, Corno, D Donato, Musella, Chiappetta, Bosco, Panici, Alvaro, Cardinale |
Cells | 2019 |
|
Antibodies to a CA 19-9 Related Antigen Complex Identify SOX9 Expressing Progenitor Cells In Human Foetal Pancreas and Pancreatic Adenocarcinoma
AM Farley, DR Braxton, J Li, K Trounson, S Sakar-Dey, B Nayer, T Ikeda, KX Lau, W Hardikar, K Hasegawa, MF Pera |
Scientific Reports | 2019 |
|
Dysregulated activation of fetal liver programme in acute liver failure
J Hyun, SH Oh, RT Premont, CD Guy, CL Berg, AM Diehl |
Gut | 2019 |
|
Stem and progenitor cells in skeletal development
Ono N, Balani DH, Kronenberg HM |
Current topics in developmental biology | 2019 |
|
Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo
DH Balani, HM Kronenberg |
Bone | 2018 |
|
Calcium Signaling in Liver Injury and Regeneration
N Oliva-Vilarnau, S Hankeova, SU Vorrink, S Mkrtchian, ER Andersson, VM Lauschke |
Frontiers in Medicine | 2018 |
|
Modeling human pancreatic beta cell dedifferentiation
M Diedisheim, M Oshima, O Albagli, CW Huldt, I Ahlstedt, M Clausen, S Menon, A Aivazidis, AC Andreasson, WG Haynes, P Marchetti, L Marselli, M Armanet, F Chimienti, R Scharfmann |
Molecular Metabolism | 2018 |
|
SOX9 expression decreases survival of patients with intrahepatic cholangiocarcinoma by conferring chemoresistance
X Yuan, J Li, C Coulouarn, T Lin, L Sulpice, D Bergeat, CD Torre, R Liebe, N Gretz, MP Ebert, S Dooley, HL Weng |
British Journal of Cancer | 2018 |
|
SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis
VS Athwal, J Pritchett, J Llewellyn, K Martin, E Camacho, SM Raza, A PhythianAdams, LJ Birchall, AF Mullan, K Su, L Pearmain, G Dolman, AM Zaitoun, SL Friedman, A MacDonald, WL Irving, IN Guha, NA Hanley, KP Hanley |
EMBO Molecular Medicine | 2017 |
|
SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer
H Zhou, Y Qin, S Ji, J Ling, J Fu, Z Zhuang, X Fan, L Song, X Yu, PJ Chiao |
Oncogene | 2017 |
|
Molecular mechanisms of Sox transcription factors during the development of liver, bile duct, and pancreas
C Yin |
Seminars in Cell & Developmental Biology | 2016 |
|
SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma
T Kawai, K Yasuchika, T Ishii, Y Miyauchi, H Kojima, R Yamaoka, H Katayama, EY Yoshitoshi, S Ogiso, S Kita, K Yasuda, K Fukumitsu, J Komori, E Hatano, Y Kawaguchi, S Uemoto |
Scientific Reports | 2016 |
|
Rat liver regeneration following ablation with irreversible electroporation
A Golberg, BG Bruinsma, M Jaramillo, ML Yarmush, BE Uygun |
PeerJ | 2016 |
|
Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases
E Arvaniti, P Moulos, A Vakrakou, C Chatziantoniou, C Chadjichristos, P Kavvadas, A Charonis, PK Politis |
Scientific Reports | 2016 |
|
Dimerization and Transactivation Domains as Candidates for Functional Modulation and Diversity of Sox9
MT Geraldo, GT Valente, RT Nakajima, C Martins, K Roemer |
PloS one | 2016 |
|
Progenitor cell niches in the human pancreatic duct system and associated pancreatic duct glands: an anatomical and immunophenotyping study
G Carpino, A Renzi, V Cardinale, A Franchitto, P Onori, D Overi, M Rossi, PB Berloco, D Alvaro, LM Reid, E Gaudio |
Journal of Anatomy | 2015 |
|
Cell competition: Winning out by losing notch
MP Alcolea, PH Jones |
Cell cycle (Georgetown, Tex.) | 2015 |
|
The SOX9 upstream region prone to chromosomal aberrations causing campomelic dysplasia contains multiple cartilage enhancers
B Yao, Q Wang, CF Liu, P Bhattaram, W Li, TJ Mead, JF Crish, V Lefebvre |
Nucleic Acids Research | 2015 |
|
The expression and activity of thioredoxin reductase 1 splice variants v1 and v2 regulate the expression of genes associated with differentiation and adhesion
I Nalvarte, AE Damdimopoulos, J Ruegg, G Spyrou |
Bioscience Reports | 2015 |
|
The versatile functions of Sox9 in development, stem cells, and human diseases
A Jo, S Denduluri, B Zhang, Z Wang, L Yin, Z Yan, R Kang, LL Shi, J Mok, MJ Lee, RC Haydon |
Genes & Diseases | 2014 |
|
Sox9: A Master Regulator of the Pancreatic Program
PA Seymour |
The review of diabetic studies : RDS | 2014 |
|
The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar
C Dorrell, B Tarlow, Y Wang, PS Canaday, A Haft, J Schug, PR Streeter, MJ Finegold, LT Shenje, KH Kaestner, M Grompe |
Stem Cell Research | 2014 |
|
Clinical implication of Sox9 and activated Akt expression in pancreatic ductal adenocarcinoma
S Xia, Z Feng, X Qi, Y Yin, J Jin, Y Wu, H Wu, Y Feng, M Tao |
Medical Oncology | 2014 |
|
SOX9 Regulates Multiple Genes in Chondrocytes, Including Genes Encoding ECM Proteins, ECM Modification Enzymes, Receptors, and Transporters
C Oh, Y Lu, S Liang, Y Mori-Akiyama, D Chen, B Crombrugghe, H Yasuda, H Ariga |
PloS one | 2014 |
|
Underlying potential: cellular and molecular determinants of adult liver repair
Anna Mae Diehl, John Chute |
Journal of Clinical Investigation | 2013 |
|
Upregulation of SOX9 in osteosarcoma and its association with tumor progression and patients' prognosis
H Zhu, J Tang, M Tang, H Cai |
Diagnostic Pathology | 2013 |
|
Concise review: Clinical programs of stem cell therapies for liver and pancreas: Stem Cell Therapies for Liver and Pancreas
G Lanzoni, T Oikawa, Y Wang, CB Cui, G Carpino, V Cardinale, D Gerber, M Gabriel, J Dominguez-Bendala, ME Furth, E Gaudio, D Alvaro, L Inverardi, LM Reid |
Stem Cells | 2013 |
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