Abnormalities in cell-cell communication and growth factor signaling pathways can
lead to defects in maternal-fetal interactions during pregnancy, including
immunologic rejection of the fetal/placental unit. In this study, we discovered that
bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation
physiology and fertility. Despite normal implantation and early placental/fetal
development, deletion of
Takashi Nagashima, Qinglei Li, Caterina Clementi, John P. Lydon, Francesco J. DeMayo, Martin M. Matzuk