The immune system’s battle against pathogens includes the “respiratory burst,” a rapid release of ROS from leukocytes, thought to play a role in destroying the invading species. In this issue of the JCI, Paiva et al. demonstrate that oxidative stress actually enhances infection with the protozoan Trypanosoma cruzi, by a mechanism that may involve facilitating parasite access to iron. Their findings suggest a novel direction for the development of drugs against intracellular parasites.
Norma W. Andrews
Title and authors | Publication | Year |
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Reactive species and pathogen antioxidant networks during phagocytosis
L Piacenza, M Trujillo, R Radi |
Journal of Experimental Medicine | 2019 |
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in Trypanosoma cruzi
AC Mesías, NJ Garg, MP Zago |
Frontiers in Cellular and Infection Microbiology | 2019 |
Metabolic syndrome agravates cardiovascular, oxidative and inflammatory dysfunction during the acute phase of Trypanosoma cruzi infection in mice
BF Lucchetti, N Boaretto, FN Lopes, AD Malvezi, MI Lovo-Martins, VL Tatakihara, V Fattori, RS Pereira, WA Verri, EJ de Almeida Araujo, P Pinge-Filho, MC Martins-Pinge |
Scientific Reports | 2019 |