The immune system’s battle against pathogens includes the “respiratory burst,” a rapid release of ROS from leukocytes, thought to play a role in destroying the invading species. In this issue of the JCI, Paiva et al. demonstrate that oxidative stress actually enhances infection with the protozoan Trypanosoma cruzi, by a mechanism that may involve facilitating parasite access to iron. Their findings suggest a novel direction for the development of drugs against intracellular parasites.
Norma W. Andrews
Title and authors | Publication | Year |
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Cardiomyocyte oxidants production may signal to T. cruzi intracellular development
PP Dias, RF Capila, NF Couto, D Estrada, FR Gadelha, R Radi, L Piacenza, LO Andrade, HB Tanowitz |
PLoS neglected tropical diseases | 2017 |
Leishmania donovani chaperonin 10 regulates parasite internalization and intracellular survival in human macrophages
L Colineau, J Clos, KM Moon, LJ Foster, NE Reiner |
Medical Microbiology and Immunology | 2017 |