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Citations to this article

Perspectives on whole-organ assembly: moving toward transplantation on demand
Alejandro Soto-Gutierrez, … , Harald C. Ott, Thomas W. Gilbert
Alejandro Soto-Gutierrez, … , Harald C. Ott, Thomas W. Gilbert
Published November 1, 2012
Citation Information: J Clin Invest. 2012;122(11):3817-3823. https://doi.org/10.1172/JCI61974.
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Perspectives on whole-organ assembly: moving toward transplantation on demand

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Abstract

There is an ever-growing demand for transplantable organs to replace acute and chronically damaged tissues. This demand cannot be met by the currently available donor organs. Efforts to provide an alternative source have led to the development of organ engineering, a discipline that combines cell biology, tissue engineering, and cell/organ transplantation. Over the last several years, engineered organs have been implanted into rodent recipients and have shown modest function. In this article, we summarize the most recent advances in this field and provide a perspective on the challenges of translating this promising new technology into a proven regenerative therapy.

Authors

Alejandro Soto-Gutierrez, Jason A. Wertheim, Harald C. Ott, Thomas W. Gilbert

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Total citations by year

Year: 2022 2021 2020 2018 2017 2016 2015 2014 2013 2009 Total
Citations: 1 3 3 2 2 5 14 7 7 1 45
Citation information
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Citations to this article (45)

Title and authors Publication Year
Can Heart Valve Decellularization Be Standardized? A Review of the Parameters Used for the Quality Control of Decellularization Processes
F Naso, A Gandaglia
Frontiers in Bioengineering and Biotechnology 2022
Decellularization Methods of Tissue and Whole Organ in Tissue Engineering
AM Kajbafzadeh
2021
3D bioprinting of stem cell-laden cardiac patch: A promising alternative for myocardial repair
S Das, H Nam, J Jang
2021
Exploring Insulin Production Following Alveolar Islet Transplantation (AIT)
H Lau, T Khosrawipour, S Li, M Alexander, P Frelkiewicz, MK Labbé, S Stieglitz, JR Lakey, W Kielan, V Khosrawipour
International journal of molecular sciences 2021
Therapeutic targets for liver regeneration after acute severe injury: a preclinical overview
H Kojima, K Nakamura, JW Kupiec-Weglinski
Expert Opinion on Therapeutic Targets 2020
Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells
K Takeishi, AC de lHortet, Y Wang, K Handa, J Guzman-Lepe, K Matsubara, K Morita, S Jang, N Haep, RM Florentino, F Yuan, K Fukumitsu, K Tobita, W Sun, J Franks, ER Delgado, EM Shapiro, NA Fraunhoffer, AW Duncan, H Yagi, T Mashimo, IJ Fox, A Soto-Gutierrez
Cell Reports 2020
Islet Transplantation in the Lung via Endoscopic Aerosolization: Investigation of Feasibility, Islet Cluster Cell Vitality, and Structural Integrity
H Lau, T Khosrawipour, M Alexander, S Li, A Mikolajczyk, J Nicpon, J Schubert, J Bania, JR Lakey, V Khosrawipour
Cell Transplantation 2020
The rat pancreatic body tail as a source of a novel extracellular matrix scaffold for endocrine pancreas bioengineering
H Yu, Y Chen, H Kong, Q He, H Sun, PA Bhugul, Q Zhang, B Chen, M Zhou
Journal of biological engineering 2018
Fabrication of Tongue Extracellular Matrix and Reconstitution of Tongue Squamous Cell Carcinoma In Vitro
Y Yao, W Lin, Y Zhang
Journal of visualized experiments : JoVE 2018
Experimental Evaluation of Kidney Regeneration by Organ Scaffold Recellularization
A Remuzzi, M Figliuzzi, B Bonandrini, S Silvani, N Azzollini, R Nossa, A Benigni, G Remuzzi
Scientific Reports 2017
Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine
N Takata, M Eiraku
Journal of Human Genetics 2017
Human Organotypic Lung Tumor Models: Suitable For Preclinical 18F-FDG PET-Imaging
D Fecher, E Hofmann, A Buck, R Bundschuh, S Nietzer, G Dandekar, T Walles, H Walles, K Lückerath, M Steinke, N Cordes
PloS one 2016
Liver-Regenerative Transplantation: Regrow and Reset
AC de l'Hortet, K Takeishi, J Guzman-Lepe, K Handa, K Matsubara, K Fukumitsu, K Dorko, SC Presnell, H Yagi, A Soto-Gutierrez
American Journal of Transplantation 2016
The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas:
A Peloso, L Urbani, P Cravedi, R Katari, P Maghsoudlou, ME Fallas, V Sordi, A Citro, C Purroy, G Niu, JP McQuilling, S Sittadjody, AC Farney, SS Iskandar, JP Zambon, J Rogers, RJ Stratta, EC Opara, L Piemonti, CM Furdui, S Soker, PD Coppi, G Orlando
Annals of Surgery 2016
Novel technology for liver regeneration and replacement: Supplement
JA Wertheim
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2016
Efficient recellularisation of decellularised whole-liver grafts using biliary tree and foetal hepatocytes
S Ogiso, K Yasuchika, K Fukumitsu, T Ishii, H Kojima, Y Miyauchi, R Yamaoka, J Komori, H Katayama, T Kawai, EY Yoshitoshi, S Kita, K Yasuda, S Uemoto
Scientific Reports 2016
Stem Cell-Based Therapy in Idiopathic Pulmonary Fibrosis
M Barczyk, M Schmidt, S Mattoli
Stem Cell Reviews and Reports 2015
Micro and nanoparticle drug delivery systems for preventing allotransplant rejection
JD Fisher, AP Acharya, SR Little
Clinical Immunology 2015
Current achievements and future perspectives in whole-organ bioengineering
A Peloso, A Dhal, JP Zambon, P Li, G Orlando, A Atala, S Soker
Stem Cell Research & Therapy 2015
Pushing the Envelope in Tissue Engineering: Ex Vivo Production of Thick Vascularized Cardiac Extracellular Matrix Constructs
U Sarig, EB Nguyen, Y Wang, S Ting, T Bronshtein, H Sarig, N Dahan, M Gvirtz, S Reuveny, SK Oh, T Scheper, YC Boey, SS Venkatraman, M Machluf
Tissue Engineering Part A 2015
A polymer–extracellular matrix composite with improved thromboresistance and recellularization properties
B Jiang, B Akgun, RC Lam, GA Ameer, JA Wertheim
Acta Biomaterialia 2015
Advancing biomaterials of human origin for tissue engineering
FM Chen, X Liu
Progress in Polymer Science 2015
Development and characterization of acellular extracellular matrix scaffolds from porcine menisci for use in cartilage tissue engineering
YC Chen, RN Chen, HJ Jhan, DZ Liu, HO Ho, Y Mao, J Kohn, MT Sheu
Tissue Engineering Part C: Methods 2015
The Potential of the Combination of CRISPR/Cas9 and Pluripotent Stem Cells to Provide Human Organs from Chimaeric Pigs
W Feng, Y Dai, L Mou, D Cooper, D Shi, Z Cai
International journal of molecular sciences 2015
Freezing/Thawing without Cryoprotectant Damages Native but not Decellularized Porcine Renal Tissue
N Poornejad, TS Frost, DR Scott, BB Elton, PR Reynolds, BL Roeder, AD Cook
Organogenesis 2015
Future Economics of Liver Transplantation: A 20-Year Cost Modeling Forecast and the Prospect of Bioengineering Autologous Liver Grafts
D Habka, D Mann, R Landes, A Soto-Gutierrez, S Gruttadauria
PloS one 2015
Dual-purpose bioreactors to monitor non-invasive physical and biochemical markers of kidney and liver scaffold recellularization
JS Uzarski, BM Bijonowski, B Wang, HH Ward, A Wandinger-Ness, WM Miller, JA Wertheim
Tissue Engineering Part C: Methods 2015
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
JS Uzarski, J Su, Y Xie, ZJ Zhang, HH Ward, A Wandinger-Ness, WM Miller, JA Wertheim
Journal of visualized experiments : JoVE 2015
Challenging Regeneration to Transform Medicine
A Tsukamoto, SE Abbot, LC Kadyk, ND DeWitt, DV Schaffer, JA Wertheim, KJ Whittlesey, MJ Werner
Stem Cells Translational Medicine 2015
Procedure for Decellularization of Rat Livers in an Oscillating-pressure Perfusion Device
K Hillebrandt, D Polenz, A Butter, P Tang, A Reutzel-Selke, A Andreou, H Napierala, N Raschzok, J Pratschke, IM Sauer, B Struecker
Journal of visualized experiments : JoVE 2015
Epithelial Cell Differentiation of Human Mesenchymal Stromal Cells in Decellularized Lung Scaffolds
JJ Mendez, M Ghaedi, D Steinbacher, LE Niklason
Tissue Engineering Part A 2014
Assembly of Human Organs from Stem Cells to Study Liver Disease
K Handa, K Matsubara, K Fukumitsu, J Guzman-Lepe, A Watson, A Soto-Gutierrez
The American Journal of Pathology 2014
Mesenchymal stem cells support hepatocyte function in engineered liver grafts
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Organogenesis 2014
Bioengineering Kidneys for Transplantation
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Seminars in Nephrology 2014
Optimization and Critical Evaluation of Decellularization Strategies to Develop Renal Extracellular Matrix Scaffolds as Biological Templates for Organ Engineering and Transplantation: A Renal Biomatrix for Organ Engineering
M Caralt, JS Uzarski, S Iacob, KP Obergfell, N Berg, BM Bijonowski, KM Kiefer, HH Ward, A Wandinger-Ness, WM Miller, ZJ Zhang, MM Abecassis, JA Wertheim
American Journal of Transplantation 2014
Low oxygen tension enhances the generation of lung progenitor cells from mouse embryonic and induced pluripotent stem cells
E Garreta, E Melo, D Navajas, R Farre
Physiological Reports 2014
Perfusion decellularization of whole organs
JP Guyette, SE Gilpin, JM Charest, LF Tapias, , HC Ott
Nature Protocols 2014
Transplantable liver production plan
T Hata, S Uemoto, E Kobayashi
Organogenesis 2013
Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases. Comprehensive Review of the Recent Literature 2010–2012
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Annals of the American Thoracic Society 2013
Liver repopulation and regeneration: new approaches to old questions
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Current Opinion in Organ Transplantation 2013
Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering
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Biomaterials 2013
Urinary bladder matrix promotes site appropriate tissue formation following right ventricle outflow tract repair
NT Remlinger, TW Gilbert, M Yoshida, BN Guest, R Hashizume, ML Weaver, WR Wagner, BN Brown, K Tobita, PD Wearden
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Lab on a Chip 2013
Pulmonary surfactant: an immunological perspective
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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009

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