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Citations to this article

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor–mediated kidney fibrosis
Jian-dong Zhang, … , Daian Chen, Steven D. Crowley
Jian-dong Zhang, … , Daian Chen, Steven D. Crowley
Published April 17, 2014
Citation Information: J Clin Invest. 2014;124(5):2198-2203. https://doi.org/10.1172/JCI61368.
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Brief Report Nephrology Article has an altmetric score of 17

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor–mediated kidney fibrosis

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Abstract

In a wide array of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal interstitium. Here, we examined the actions of AT1 receptors on macrophages in progressive renal fibrosis and found that macrophage-specific AT1 receptor deficiency exacerbates kidney fibrosis induced by unilateral ureteral obstruction (UUO). Macrophages isolated from obstructed kidneys of mice lacking AT1 receptors solely on macrophages had heightened expression of proinflammatory M1 cytokines, including IL-1. Evaluation of isolated AT1 receptor–deficient macrophages confirmed the propensity of these cells to produce exaggerated levels of M1 cytokines, which led to more severe renal epithelial cell damage via IL-1 receptor activation in coculture compared with WT macrophages. A murine kidney crosstransplantation concomitant with UUO model revealed that augmentation of renal fibrosis instigated by AT1 receptor–deficient macrophages is mediated by IL-1 receptor stimulation in the kidney. This study indicates that a key role of AT1 receptors on macrophages is to protect the kidney from fibrosis by limiting activation of IL-1 receptors in the kidney.

Authors

Jian-dong Zhang, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, Huixia Jin, Jose A. Gomez, Anne F. Buckley, William S. Lefler, Daian Chen, Steven D. Crowley

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 2 3 1 10 6 7 7 10 9 8 2 65
Citation information
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Citations to this article in year 2018 (10)

Title and authors Publication Year
RGC32 Promotes Bleomycin-Induced Systemic Sclerosis in a Murine Disease Model by Modulating Classically Activated Macrophage Function
C Sun, SY Chen
Journal of immunology (Baltimore, Md. : 1950) 2018
Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology
SJ Forrester, GW Booz, CD Sigmund, TM Coffman, T Kawai, V Rizzo, R Scalia, S Eguchi
Physiological reviews 2018
Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology
S Eguchi, T Kawai, R Scalia, V Rizzo
Hypertension 2018
Interleukin-1 β Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis
DR Lemos, M McMurdo, G Karaca, J Wilflingseder, IA Leaf, N Gupta, T Miyoshi, K Susa, BG Johnson, K Soliman, G Wang, R Morizane, JV Bonventre, JS Duffield
Journal of the American Society of Nephrology : JASN 2018
Salt, Hypertension, and Immunity
AJ Rucker, NP Rudemiller, SD Crowley
Annual Review of Physiology 2018
Inflammation as a Regulator of the Renin-Angiotensin System and Blood Pressure
R Satou, H Penrose, LG Navar
Current Hypertension Reports 2018
Interleukin 1 receptor (IL-1R1) activation exacerbates toxin-induced acute kidney injury
JR Privratsky, J Zhang, X Lu, N Rudemiller, Q Wei, YR Yu, MD Gunn, SD Crowley
American journal of physiology. Renal physiology 2018
Angiotensin-converting enzyme in innate and adaptive immunity
KE Bernstein, Z Khan, JF Giani, DY Cao, EA Bernstein, XZ Shen
Nature Reviews Nephrology 2018
TGF-β1 promotes expression of fibrosis-related genes through the induction of histone variant H3.3 and histone chaperone HIRA
T Shindo, S Doi, A Nakashima, K Sasaki, K Arihiro, T Masaki
Scientific Reports 2018
Cytokine Profiles Associated With Angiotensin II Type 1 Receptor Antibodies
MH Pearl, J Grotts, M Rossetti, Q Zhang, DW Gjertson, P Weng, D Elashoff, EF Reed, ET Chambers
Kidney International Reports 2018

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