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Citations to this article

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor–mediated kidney fibrosis
Jian-dong Zhang, … , Daian Chen, Steven D. Crowley
Jian-dong Zhang, … , Daian Chen, Steven D. Crowley
Published April 17, 2014
Citation Information: J Clin Invest. 2014;124(5):2198-2203. https://doi.org/10.1172/JCI61368.
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Brief Report Nephrology Article has an altmetric score of 17

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor–mediated kidney fibrosis

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Abstract

In a wide array of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal interstitium. Here, we examined the actions of AT1 receptors on macrophages in progressive renal fibrosis and found that macrophage-specific AT1 receptor deficiency exacerbates kidney fibrosis induced by unilateral ureteral obstruction (UUO). Macrophages isolated from obstructed kidneys of mice lacking AT1 receptors solely on macrophages had heightened expression of proinflammatory M1 cytokines, including IL-1. Evaluation of isolated AT1 receptor–deficient macrophages confirmed the propensity of these cells to produce exaggerated levels of M1 cytokines, which led to more severe renal epithelial cell damage via IL-1 receptor activation in coculture compared with WT macrophages. A murine kidney crosstransplantation concomitant with UUO model revealed that augmentation of renal fibrosis instigated by AT1 receptor–deficient macrophages is mediated by IL-1 receptor stimulation in the kidney. This study indicates that a key role of AT1 receptors on macrophages is to protect the kidney from fibrosis by limiting activation of IL-1 receptors in the kidney.

Authors

Jian-dong Zhang, Mehul B. Patel, Robert Griffiths, Paul C. Dolber, Phillip Ruiz, Matthew A. Sparks, Johannes Stegbauer, Huixia Jin, Jose A. Gomez, Anne F. Buckley, William S. Lefler, Daian Chen, Steven D. Crowley

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Total
Citations: 2 3 1 10 6 7 7 10 9 8 2 65
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2017 (9)

Title and authors Publication Year
The ligand-bound thyroid hormone receptor in macrophages ameliorates kidney injury via inhibition of nuclear factor-κB activities
F Furuya, T Ishii, S Tamura, K Takahashi, H Kobayashi, M Ichijo, S Takizawa, M Kaneshige, K Suzuki-Inoue, K Kitamura
Scientific Reports 2017
Role of the Immune System in Hypertension
B Rodriguez-Iturbe, H Pons, RJ Johnson
Physiological reviews 2017
The role of macrophages in hypertension and its complications
AJ Rucker, SD Crowley
Pflügers Archiv - European Journal of Physiology 2017
Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells
P Ponnuswamy, J Joffre, O Herbin, B Esposito, L Laurans, CJ Binder, TF Tedder, L Zeboudj, X Loyer, A Giraud, Y Zhang, A Tedgui, Z Mallat, H Ait-Oufella
Scientific Reports 2017
The role of chemokines in hypertension and consequent target organ damage
NP Rudemiller, SD Crowley
Pharmacological Research 2017
Immunologic Effects of the Renin-Angiotensin System
SD Crowley, NP Rudemiller
Journal of the American Society of Nephrology : JASN 2017
Macrophages in neuroinflammation: role of the renin-angiotensin-system
A Hammer, J Stegbauer, RA Linker
Pflügers Archiv - European Journal of Physiology 2017
Macrophages under pressure: the role of macrophage polarization in hypertension
SC Harwani
Translational Research 2017
Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy
J Wang, W Wang, W Guo, Y Ma, T Ji, B Zhang
Experimental and therapeutic medicine 2017

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