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Pieter Van Vlierberghe, Adolfo Ferrando
Published October 1, 2012
Citation Information: J Clin Invest. 2012;122(10):3398-3406. https://doi.org/10.1172/JCI61269.
Citation Information: J Clin Invest. 2012;122(10):3398-3406. https://doi.org/10.1172/JCI61269.
Abstract
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.
Authors
Pieter Van Vlierberghe, Adolfo Ferrando
Total citations by year
Citation information
Citations to this article (249)
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International journal of molecular sciences | 2020 |
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Large-scale circular RNA deregulation in T-ALL: unlocking unique ectopic expression of molecular subtypes
A Buratin, M Paganin, E Gaffo, AD Molin, J Roels, G Germano, MT Siddi, V Serafin, MD Decker, S Gachet, K Durinck, F Speleman, T Taghon, G te Kronnie, PV Vlierberghe, S Bortoluzzi |
Blood Advances | 2020 |
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WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia
J Hu, T Wang, J Xu, S Wu, L Wang, H Su, J Jiang, M Yue, J Wang, D Wang, P Li, F Zhou, Y Liu, G Qing, H Liu |
Haematologica | 2020 |
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Drug Resistance Biomarkers and Their Clinical Applications in Childhood Acute Lymphoblastic Leukemia
N Aberuyi, S Rahgozar, ES Ghodousi, K Ghaedi |
Frontiers in Oncology | 2020 |
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LEF1 Induces DHRS2 Gene Expression in Human Acute Leukemia Jurkat T-Cells
SS Ekmekci, Z Emrence, N Abacı, M Sarıman, B Salman, CG Ekmekci, Ç Güleç |
Turkish Journal of Hematology | 2020 |
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The oxidation of (−)-epigallocatechin-3-gallate inhibits T-cell acute lymphoblastic leukemia cell line HPB-ALL via the regulation of Notch1 expression
Y Wang, J Wang, H Yang, B Zhang, P Zhang, P Sun, N Zhang, Y Wang, J Sheng, X Wang, C Zi |
RSC Advances | 2020 |
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Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma
I Vázquez-Domínguez, L González-Sánchez, P López-Nieva, P Fernández-Navarro, M Villa-Morales, MÁ Cobos-Fernández, I Sastre, MF Fraga, AF Fernández, M Malumbres, M Salazar-Roa, O Graña-Castro, J Santos, P Llamas, JL López-Lorenzo, J Fernández-Piqueras |
Oncogene | 2019 |
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Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia
J Gao, MV Meter, SH Lopez, G Chen, Y Huang, S Ren, Q Zhao, J Rojas, C Gurer, G Thurston, F Kuhnert |
Disease models & mechanisms | 2019 |
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LMO2 activation by deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis
T Morishima, AC Krahl, M Nasri, Y Xu, N Aghaallaei, B Findik, M Klimiankou, M Ritter, MD Hartmann, CJ Gloeckner, S Stefanczyk, C Lindner, B Oswald, R Bernhard, K Hähnel, U Hermanutz-Klein, M Ebinger, R Handgretinger, N Casadei, K Welte, M Andre, P Müller, B Bajoghli, J Skokowa |
Blood | 2019 |
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Proteasome Inhibition by Carfilzomib Induced Apotosis and Autophagy in a T-cell Acute Lymphoblastic Leukemia Cell Line
Maryam Sadat Hosseini, Mohammad Hossein Mohammadi, Rouhollah Vahabpour Roudsari, Leila Jafari, Pargol Mashati, Ahmad Gharehbaghian |
IRAN J PHARM RES | 2019 |
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Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia
M Alcantara, M Simonin, L Lhermitte, A Touzart, ME Dourthe, M Latiri, N Grardel, JM Cayuela, Y Chalandon, C Graux, H Dombret, N Ifrah, A Petit, E Macintyre, A Baruchel, N Boissel, V Asnafi |
Blood Advances | 2019 |
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The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
ZT Chebihi, A Belkhayat, E Chadli, L Hessissen, ME Khorassani, ME Kababri, A Kili, M Khattab, Y Bakri, N Dakka |
Leukemia research reports | 2019 |
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CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia
W Jang, J Park, A Kwon, H Choi, J Kim, GD Lee, E Han, DW Jekarl, H Chae, K Han, JH Yoon, S Lee, NG Chung, B Cho, M Kim, Y Kim |
Experimental & molecular medicine | 2019 |
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Xenopus tropicalis: Joining the Armada in the Fight Against Blood Cancer
D Dimitrakopoulou, D Tulkens, PV Vlieberghe, K Vleminckx |
Frontiers in physiology | 2019 |
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Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level
D Castillo, JM Galvez, LJ Herrera, F Rojas, O Valenzuela, O Caba, J Prados, I Rojas, E Hernandez-Lemus |
PloS one | 2019 |
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Potent and Highly Selective Aldo–Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
K Verma, T Zang, TM Penning, PC Trippier |
Journal of Medicinal Chemistry | 2019 |
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ZEB2 and LMO2 drive immature T-cell lymphoblastic leukemia via distinct oncogenic mechanisms
S Goossens, J Wang, CS Tremblay, JD Medts, S TSas, T Nguyen, J Saw, K Haigh, DJ Curtis, PV Vlierberghe, G Berx, T Taghon, JJ Haigh |
Haematologica | 2019 |
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The effect of co-occurring lesions on leukaemogenesis and drug response in T-ALL and ETP-ALL
PT Shirazi, LN Eadie, SL Heatley, TP Hughes, DT Yeung, DL White |
British Journal of Cancer | 2019 |
|
Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells
EJ Ha, KY Kim, CE Kim, DY Jun, YH Kim |
Oxidative medicine and cellular longevity | 2019 |
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The Expression of P53, MDM2, c-myc, and P14ARF Genes in Newly Diagnosed Acute Lymphoblastic Leukemia Patients
MA Farsani, M Rafiee, HA Nezhad, S Salari, A Gharehbaghian, MH Mohammadi |
Indian Journal of Hematology and Blood Transfusion | 2019 |
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Flow cytometric evaluation of CD38 expression levels in the newly diagnosed T-cell acute lymphoblastic leukemia and the effect of chemotherapy on its expression in measurable residual disease, refractory disease and relapsed disease: an implication for anti-CD38 immunotherapy
PR Tembhare, H Sriram, T Khanka, G Chatterjee, D Panda, S Ghogale, Y Badrinath, N Deshpande, NV Patkar, G Narula, B Bagal, H Jain, M Sengar, N Khattry, S Banavali, S Gujral, PG Subramanian |
Journal for ImmunoTherapy of Cancer | 2019 |
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Restraining the Proliferation of Acute Lymphoblastic Leukemia Cells by Genistein through Up-regulation of B-cell Translocation Gene-3 at Transcription Level
Masoumeh Abedi Nejad, Mohsen Nikbakht, Masoomeh Afsa, Kianoosh Malekzadeh |
Galen medical journal | 2019 |
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Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds
RO Alabi, G Farber, CP Blobel |
Physiological reviews | 2018 |
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Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation
F Ferrandino, G Bernardini, G Tsaouli, P Grazioli, AF Campese, C Noce, A Ciuffetta, A Vacca, ZM Besharat, D Bellavia, I Screpanti, MP Felli |
Oncogene | 2018 |
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Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia
A Padgaonkar, O Rechkoblit, RV Carpio, V Pallela, VS DRC, SC Cosenza, SJ Baker, MV Reddy, A Aggarwal, PE Reddy |
Oncotarget | 2018 |
|
Rho guanosine nucleotide exchange factors are not such bad guys after all in cancer a
J Robles-Valero, LF Lorenzo-Martín, I Fernández-Pisonero, XR Bustelo |
Small GTPases | 2018 |
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Lmo2 expression defines tumor cell identity during T‐cell leukemogenesis
I GarcíaRamírez, S Bhatia, G RodríguezHernández, I GonzálezHerrero, C Walter, SG de TenaDávila, S Parvin, O Haas, W Woessmann, M Stanulla, M Schrappe, M Dugas, Y Natkunam, A Orfao, V Domínguez, B Pintado, O Blanco, D AlonsoLópez, JD Rivas, A MartínLorenzo, R Jiménez, FJ Criado, MB Cenador, IS Lossos, C VicenteDueñas, A Borkhardt, J Hauer, I SánchezGarcía |
The EMBO Journal | 2018 |
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Rho GTPases: Methods and Protocols
F Rivero |
2018 | |
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Defining the molecular basis of oncogenic cooperation between TAL1 expression and Pten deletion in T-ALL using a novel pro-T-cell model system
S Bornschein, S Demeyer, R Stirparo, O Gielen, C Vicente, E Geerdens, B Ghesquière, S Aerts, J Cools, CE de Bock |
Leukemia | 2018 |
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MIR-708 promotes phagocytosis to eradicate T-ALL cells by targeting CD47
W Huang, WT Wang, K Fang, ZH Chen, YM Sun, C Han, LY Sun, XQ Luo, YQ Chen |
Molecular Cancer | 2018 |
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An unexpected tumor suppressor role for VAV1a
XR Bustelo, LF Lorenzo-Martín, M Cuadrado, I Fernández-Pisonero, J Robles-Valero |
Molecular & Cellular Oncology | 2018 |
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Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
G Tzoneva, CL Dieck, K Oshima, A Ambesi-Impiombato, M Sánchez-Martín, CJ Madubata, H Khiabanian, J Yu, E Waanders, I Iacobucci, ML Sulis, M Kato, K Koh, M Paganin, G Basso, JM Gastier-Foster, ML Loh, R Kirschner-Schwabe, CG Mullighan, R Rabadan, AA Ferrando |
Nature | 2018 |
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ZEB Proteins in Leukemia: Friends, Foes, or Friendly Foes?
B Soen, N Vandamme, G Berx, J Schwaller, PV Vlierberghe, S Goossens |
2018 | |
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Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia
MV Bempt, S Demeyer, M Broux, JD Bie, S Bornschein, N Mentens, R Vandepoel, E Geerdens, E Radaelli, BC Bornhauser, AE Kulozik, JP Meijerink, JP Bourquin, CE de Bock, J Cools |
Cancer Cell | 2018 |
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Inhibiting Janus Kinase 1 and BCL-2 to treat T cell acute lymphoblastic leukemia with IL7-Rα mutations
E Senkevitch, W Li, JA Hixon, C Andrews, SD Cramer, GT Pauly, T Back, K Czarra, S Durum |
Oncotarget | 2018 |
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Transcribing malignancy: transcription-associated genomic instability in cancer
B Boulianne, N Feldhahn |
Oncogene | 2017 |
|
Small genomic insertions form enhancers that misregulate oncogenes
BJ Abraham, D Hnisz, AS Weintraub, N Kwiatkowski, CH Li, Z Li, N Weichert-Leahey, S Rahman, Y Liu, J Etchin, B Li, S Shen, TI Lee, J Zhang, AT Look, MR Mansour, RA Young |
Nature Communications | 2017 |
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Defining a therapeutic window for kinase inhibitors in leukemia to avoid neutropenia
K McArthur, AA DCruz, D Segal, K Lackovic, AF Wilks, JA ODonnell, CJ Nowell, M Gerlic, DC Huang, CJ Burns, BA Croker |
Oncotarget | 2017 |
|
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia
M Seki, S Kimura, T Isobe, K Yoshida, H Ueno, Y Nakajima-Takagi, C Wang, L Lin, A Kon, H Suzuki, Y Shiozawa, K Kataoka, Y Fujii, Y Shiraishi, K Chiba, H Tanaka, T Shimamura, K Masuda, H Kawamoto, K Ohki, M Kato, Y Arakawa, K Koh, R Hanada, H Moritake, M Akiyama, R Kobayashi, T Deguchi, Y Hashii, T Imamura, A Sato, N Kiyokawa, A Oka, Y Hayashi, M Takagi, A Manabe, A Ohara, K Horibe, M Sanada, A Iwama, H Mano, S Miyano, S Ogawa, J Takita |
Nature Genetics | 2017 |
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Bone marrow sites differently imprint dormancy and chemoresistance to T-cell acute lymphoblastic leukemia
X Cahu, J Calvo, S Poglio, N Prade, B Colsch, ML Arcangeli, T Leblanc, A Petit, F Baleydier, A Baruchel, J Landman-Parker, C Junot, J Larghero, P Ballerini, E Delabesse, B Uzan, F Pflumio |
Blood Advances | 2017 |
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PI3Kγ/δ and NOTCH1 Cross-Regulate Pathways That Define the T-cell Acute Lymphoblastic Leukemia Disease Signature
E Efimenko, UP Davé, IV Lebedeva, Y Shen, MJ Sanchez-Quintero, D Diolaiti, A Kung, BJ Lannutti, J Chen, R Realubit, Z Niatsetskaya, V Ten, C Karan, , A Califano, TG Diacovo |
Molecular cancer therapeutics | 2017 |
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C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependent signalling
J Blain, J Bédard, M Thompson, FM Boisvert, MJ Boucher |
Scientific Reports | 2017 |
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A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
J Robles-Valero, LF Lorenzo-Martín, M Menacho-Márquez, I Fernández-Pisonero, A Abad, M Camós, ML Toribio, L Espinosa, A Bigas, XR Bustelo |
Cancer Cell | 2017 |
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Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia
S Rahman, M Magnussen, TE León, N Farah, Z Li, BJ Abraham, KZ Alapi, RJ Mitchell, T Naughton, AK Fielding, A Pizzey, S Bustraan, C Allen, T Popa, K Pike-Overzet, L Garcia-Perez, RE Gale, DC Linch, FJ Staal, RA Young, AT Look, MR Mansour |
Blood | 2017 |
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Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia
S Goossens, S Peirs, WV Loocke, J Wang, M Takawy, F Matthijssens, SE Sonderegger, K Haigh, T Nguyen, N Vandamme, M Costa, C Carmichael, FV Nieuwerburgh, D Deforce, O Kleifeld, DJ Curtis, G Berx, PV Vlierberghe, JJ Haigh |
Blood | 2017 |
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Identification of a genetically defined ultra-high-risk group in relapsed pediatric T-lymphoblastic leukemia
P Richter-Pechańska, JB Kunz, J Hof, M Zimmermann, T Rausch, OR Bandapalli, E Orlova, G Scapinello, JC Sagi, M Stanulla, M Schrappe, G Cario, R Kirschner-Schwabe, C Eckert, V Benes, JO Korbel, MU Muckenthaler, AE Kulozik |
Blood Cancer Journal | 2017 |
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Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Hematolymphoid Tumours
NA Brown, KS Elenitoba-Johnson |
Head and Neck Pathology | 2017 |
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T-ALL and thymocytes: a message of noncoding RNAs
A Wallaert, K Durinck, T Taghon, PV Vlierberghe, F Speleman |
Journal of Hematology & Oncology | 2017 |
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The T-ALL related gene BCL11B regulates the initial stages of human T-cell differentiation
VL Ha, A Luong, F Li, D Casero, J Malvar, YM Kim, R Bhatia, GM Crooks, C Parekh |
Leukemia | 2017 |
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Homeobox protein TLX3 activates miR-125b expression to promote T-cell acute lymphoblastic leukemia
L Renou, PY Boelle, C Deswarte, S Spicuglia, A Benyoucef, J Calvo, B Uzan, M Belhocine, A Cieslak, J Landman-Parker, A Baruchel, V Asnafi, F Pflumio, P Ballerini, I Naguibneva |
Blood Advances | 2017 |
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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
GE Winter, A Mayer, DL Buckley, MA Erb, JE Roderick, S Vittori, JM Reyes, J Iulio, A Souza, CJ Ott, JM Roberts, R Zeid, TG Scott, J Paulk, K Lachance, CM Olson, S Dastjerdi, S Bauer, CY Lin, NS Gray, MA Kelliher, LS Churchman, JE Bradner |
Molecular Cell | 2017 |
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Wnt5a and CCL25 promote adult T-cell acute lymphoblastic leukemia cell migration, invasion and metastasis
X Deng, Z Tu, M Xiong, K Tembo, L Zhou, P Liu, S Pan, J Xiong, X Yang, J Leng, Q Zhang, R Xiao, Q Zhang |
Oncotarget | 2017 |
|
Meta-analysis of the clinical characteristics and prognostic relevance of NOTCH1 and FBXW7 mutation in T-cell acute lymphoblastic leukemia
RB Liu, JG Guo, TZ Liu, CC Guo, XX Fan, X Zhang, WH Hu, XY Cai |
Oncotarget | 2017 |
|
The T-cell leukemia associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling
T Girardi, S Vereecke, SO Sulima, Y Khan, L Fancello, JW Briggs, C Schwab, JO de Beeck, J Verbeeck, J Royaert, E Geerdens, C Vicente, S Bornschein, CJ Harrison, JP Meijerink, J Cools, JD Dinman, KR Kampen, KD Keersmaecker |
Leukemia | 2017 |
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TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia
R Lobbardi, J Pinder, B Martinez-Pastor, M Theodorou, JS Blackburn, BJ Abraham, Y Namiki, M Mansour, NS Abdelfattah, A Molodtsov, G Alexe, D Toiber, M Waard, E Jain, M Boukhali, M Lion, D Bhere, K Shah, A Gutierrez, K Stegmaier, LB Silverman, RI Sadreyev, JM Asara, MA Oettinger, W Haas, AT Look, RA Young, R Mostoslavsky, G Dellaire, DM Langenau |
Cancer Discovery | 2017 |
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A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells
M Díaz, R González, D Plano, JA Palop, C Sanmartín, I Encío |
Journal of Cellular and Molecular Medicine | 2017 |
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Epigenetic regulation of lineage commitment in normal and malignant hematopoiesis by histone demethylase KDM2B
Jaclyn Andricovich, Yan Kai, Weiqun Peng, Adlen Foudi, Alexandros Tzatsos |
Journal of Clinical Investigation | 2016 |
|
Notch Signaling and the Skeleton
S Zanotti, E Canalis |
Endocrine reviews | 2016 |
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Synergistic Cytotoxic Effect of L-Asparaginase Combined with Decitabine as a Demethylating Agent in Pediatric T-ALL, with Specific Epigenetic Signature
S Serravalle, SN Bertuccio, A Astolfi, F Melchionda, A Pession |
BioMed Research International | 2016 |
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Novel Therapeutic Strategies in Acute Lymphoblastic Leukemia
A Dias, SJ Kenderian, GF Westin, MR Litzow |
Current Hematologic Malignancy Reports | 2016 |
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Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia
NP Richard, R Pippa, MM Cleary, A Puri, D Tibbitts, S Mahmood, DJ Christensen, S Jeng, S McWeeney, AT Look, BH Chang, JW Tyner, MP Vitek, MD Odero, R Sears, A Agarwal |
Oncotarget | 2016 |
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Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL
SJ Stein, EA Mack, KS Rome, KV Pajcini, T Ohtani, L Xu, Y Li, JP Meijerink, RB Faryabi, WS Pear, CJ Eaves |
PloS one | 2016 |
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Inactivation of KLF4 promotes T-cell acute lymphoblastic leukemia and activates the MAP2K7 pathway
Y Shen, CS Park, K Suppipat, TA Mistretta, M Puppi, TM Horton, K Rabin, NS Gray, JP Meijerink, HD Lacorazza |
Leukemia | 2016 |
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DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia
Y Hu, H Su, C Liu, Z Wang, L Huang, Q Wang, S Liu, S Chen, J Zhou, P Li, Z Chen, H Liu, G Qing |
Oncogene | 2016 |
|
Increased PKCα activity by Rack1 overexpression is responsible for chemotherapy resistance in T-cell acute lymphoblastic leukemia-derived cell line
J Lei, Q Li, Y Gao, L Zhao, Y Liu |
Scientific Reports | 2016 |
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Advances in Experimental Medicine and Biology
NR Harrison, FJ Laroche, A Gutierrez, H Feng |
Advances in experimental medicine and biology | 2016 |
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Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics
SK Tasian, SP Hunger |
British Journal of Haematology | 2016 |
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Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation
TA Triplett, KT Cardenas, JN Lancaster, Z Hu, HJ Selden, GJ Jasso, S Balasubramanyam, K Chan, LQ Li, X Chen, AN Marcogliese, UP Davé, PE Love, LI Ehrlich |
Proceedings of the National Academy of Sciences | 2016 |
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MLL rearrangements impact outcome in HOXA-deregulated T-lineage acute lymphoblastic leukemia: a Children’s Oncology Group Study
K Matlawska-Wasowska, H Kang, M Devidas, J Wen, RC Harvey, CK Nickl, SA Ness, M Rusch, Y Li, M Onozawa, C Martinez, BL Wood, BL Asselin, IM Chen, KG Roberts, A Baruchel, J Soulier, H Dombret, J Zhang, RS Larson, EA Raetz, WL Carroll, NJ Winick, PD Aplan, ML Loh, CG Mullighan, SP Hunger, NA Heerema, AJ Carroll, KP Dunsmore, SS Winter |
Leukemia | 2016 |
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I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs
JK Chen |
Natural Product Reports | 2016 |
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The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling
CD Ford, B Heidersdorf, F Haun, R Murillo, T Friedrich, C Borner, I Merfort |
Cell Death and Disease | 2016 |
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Activation of proto-oncogenes by disruption of chromosome neighborhoods
D Hnisz, AS Weintraub, DS Day, AL Valton, RO Bak, CH Li, J Goldmann, BR Lajoie, ZP Fan, AA Sigova, J Reddy, D Borges-Rivera, TI Lee, R Jaenisch, MH Porteus, J Dekker, RA Young |
Science | 2016 |
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Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T Leukemia
O Dobrovinskaya, G Valencia-Cruz, L Castro-Sánchez, EO Bonales-Alatorre, L Liñan-Rico, I Pottosin |
Frontiers in pharmacology | 2016 |
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Molecular genetics of childhood, adolescent and young adult non-Hodgkin lymphoma
RR Miles, RK Shah, JK Frazer |
British Journal of Haematology | 2016 |
|
T-cell acute lymphoblastic leukemia with co-expression of CD56, CD34, CD117 and CD33: A case with poor prognosis
R Eren, C Aslan, O Yokuş, M Doğu, E Suyani |
Molecular and Clinical Oncology | 2016 |
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Arsenic induced complete remission in a refractory T-ALL patient with a distinct T-cell clonal evolution without molecular complete remission: A case report
S Wu, L Xu, X Huang, S Geng, Y Xu, S Chen, L Yang, X Wu, J Weng, X Du, Y Li |
Oncology Letters | 2016 |
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Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia
RL Starza, G Barba, S Demeyer, V Pierini, DD Giacomo, V Gianfelici, C Schwab, C Matteucci, C Vicente, J Cools, M Messina, B Crescenzi, S Chiaretti, R Foa, G Basso, CJ Harrison, C Mecucci |
Haematologica | 2016 |
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The NEDD8-activating enzyme inhibitor MLN4924 induces G2 arrest and apoptosis in T-cell acute lymphoblastic leukemia
K Han, Q Wang, H Cao, G Qiu, J Cao, X Li, J Wang, B Shen, J Zhang |
Oncotarget | 2016 |
|
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia
A Benyoucef, CG Palii, C Wang, CJ Porter, A Chu, F Dai, V Tremblay, P Rakopoulos, K Singh, S Huang, F Pflumio, J Hébert, JF Couture, TJ Perkins, K Ge, FJ Dilworth, M Brand |
Genes & development | 2016 |
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Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway
A Lonetti, A Cappellini, A Bertaina, F Locatelli, A Pession, F Buontempo, C Evangelisti, C Evangelisti, E Orsini, L Zambonin, LM Neri, AM Martelli, F Chiarini |
Journal of Hematology & Oncology | 2016 |
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CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS
SR Oruganti, DJ Torres, S Krebsbach, F Asperti-Boursin, J Winters, K Matlawska-Wasowska, SS Winter, C Halsey, JL Cannon |
Leukemia | 2016 |
|
The recurrent architecture of tumour initiation, progression and drug sensitivity
A Califano, MJ Alvarez |
Nature Reviews Cancer | 2016 |
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T-cell acute lymphoblastic leukemia
EA Raetz, DT Teachey |
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program | 2016 |
|
Genomic Alterations of Non-Coding Regions Underlie Human Cancer: Lessons from T-ALL
A Rivera-Reyes, KE Hayer, CH Bassing |
Trends in Molecular Medicine | 2016 |
|
Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement
Y Wang, B Chen, Z Wang, W Zhang, K Hao, Y Chen, K Li, T Wang, Y Xie, Z Huang, X Tong |
Oncotarget | 2016 |
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Inhibition of γ‑secretase activity synergistically enhances tumour necrosis factor‑related apoptosis‑inducing ligand induced apoptosis in T‑cell acute lymphoblastic leukemia cells via upregulation of death receptor�5
L Greene, S Nathwani, D Zisterer |
Oncology Letters | 2016 |
|
miR-125b regulates differentiation and metabolic reprogramming of T cell acute lymphoblastic leukemia by directly targeting A20
Z Liu, KR Smith, HT Khong, J Huang, EY Ahn, M Zhou, M Tan |
Oncotarget | 2016 |
|
Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations
JF Spinella, P Cassart, C Richer, V Saillour, M Ouimet, S Langlois, P St-Onge, T Sontag, J Healy, MD Minden, D Sinnett |
Oncotarget | 2016 |
|
Loss of T-cell quiescence by targeting Slfn2 prevents the development and progression of T-ALL
A Goldshtein, SM Zerbib, I Omar, L Cohen-Daniel, D Popkin, M Berger |
Oncotarget | 2016 |
|
Speed of leukemia development and genetic diversity in xenograft models of T cell acute lymphoblastic leukemia
S Poglio, D Lewandowski, J Calvo, A Caye, A Gros, E Laharanne, T Leblanc, J Landman-Parker, A Baruchel, J Soulier, P Ballerini, E Clappier, F Pflumio |
Oncotarget | 2016 |
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Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen
Lynch JT, McEwen R, Crafter C, McDermott U, Garnett MJ, Barry ST, Davies BR |
Oncotarget | 2016 |
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Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL
Y Cui, M Onozawa, HR Garber, L Samsel, Z Wang, JP McCoy, S Burkett, X Wu, PD Aplan, CL Mackall |
Blood | 2015 |
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CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target
AL Perim, MK Amarante, RL Guembarovski, CE de Oliveira, MA Watanabe |
Cellular and Molecular Life Sciences | 2015 |
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Adolescent and young adult patients with cancer: a milieu of unique features
L Sender, KB Zabokrtsky |
Nature Reviews Clinical Oncology | 2015 |
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FOXP3 can modulate TAL1 transcriptional activity through interaction with LMO2
V Fleskens, M Mokry, AM van der Leun, S Huppelschoten, CE Pals, J Peeters, S Coenen, BA Cardoso, JT Barata, J Loosdregt, PJ Coffer |
Oncogene | 2015 |
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Oncogenic PTEN functions and models in T-cell malignancies
M Tesio, A Trinquand, E Macintyre, V Asnafi |
Oncogene | 2015 |
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Crucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia
K Doi, T Imai, C Kressler, H Yagita, Y Agata, M Vooijs, Y Hamazaki, J Inoue, N Minato |
Scientific Reports | 2015 |
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Therapeutic targeting of HES1 transcriptional programs in T-ALL
SA Schnell, A Ambesi-Impiombato, M Sanchez-Martin, L Belver, L Xu, Y Qin, R Kageyama, AA Ferrando |
Blood | 2015 |
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Site- and allele-specific polycomb dysregulation in T-cell leukaemia
JM Navarro, A Touzart, LC Pradel, M Loosveld, M Koubi, R Fenouil, SL Noir, MA Maqbool, E Morgado, C Gregoire, S Jaeger, E Mamessier, C Pignon, S Hacein-Bey-Abina, B Malissen, M Gut, IG Gut, H Dombret, EA Macintyre, SJ Howe, HB Gaspar, AJ Thrasher, N Ifrah, D Payet-Bornet, E Duprez, JC Andrau, V Asnafi, B Nadel |
Nature Communications | 2015 |
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Childhood acute lymphoblastic leukemia: Integrating genomics into therapy: Childhood ALL Genomics
SK Tasian, ML Loh, SP Hunger |
Cancer | 2015 |
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Developmental exposure to 2,3,7,8 tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell development and leukemogenesis
LS Ahrenhoerster, TC Leuthner, ER Tate, PA Lakatos, MD Laiosa |
Toxicology and Applied Pharmacology | 2015 |
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Biology of Childhood Acute Lymphoblastic Leukemia
D Bhojwani, JJ Yang, CH Pui |
Pediatric Clinics of North America | 2015 |
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ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
S Goossens, E Radaelli, O Blanchet, K Durinck, JV der Meulen, S Peirs, T Taghon, CS Tremblay, M Costa, MF Ghahremani, JD Medts, S Bartunkova, K Haigh, C Schwab, N Farla, T Pieters, F Matthijssens, NV Roy, JA Best, K Deswarte, P Bogaert, C Carmichael, A Rickard, S Suryani, LS Bracken, R Alserihi, K Canté-Barrett, L Haenebalcke, E Clappier, P Rondou, K Slowicka, D Huylebroeck, AW Goldrath, V Janzen, MP McCormack, RB Lock, DJ Curtis, C Harrison, G Berx, F Speleman, JP Meijerink, J Soulier, PV Vlierberghe, JJ Haigh |
Nature Communications | 2015 |
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T-ALL: ALL a matter of Translation?
T Girardi, KD Keersmaecker |
Haematologica | 2015 |
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Frequency and distribution of Notch mutations in tumor cell lines
AP Mutvei, E Fredlund, U Lendahl |
BMC Cancer | 2015 |
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The emerging complexity of gene fusions in cancer
F Mertens, B Johansson, T Fioretos, F Mitelman |
Nature Reviews Cancer | 2015 |
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Recurrent somatic mutations in regulatory regions of human cancer genomes
C Melton, JA Reuter, DV Spacek, M Snyder |
Nature Genetics | 2015 |
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High rates of submicroscopic aberrations in karyotypically normal acute lymphoblastic leukemia
MA Othman, JB Melo, IM Carreira, M Rincic, A Glaser, B Grygalewicz, B Gruhn, K Wilhelm, K Rittscher, B Meyer, ML Silva, TJ Salles, T Liehr |
Molecular cytogenetics | 2015 |
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PHF6 Degrees of Separation: The multifaceted Roles of a Chromatin Adaptor Protein
M Todd, D Ivanochko, D Picketts |
Genes & development | 2015 |
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TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia
SH Tan, AW Yam, LN Lawton, RW Wong, RA Young, AT Look, T Sanda |
Leukemia | 2015 |
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Contribution of JAK2 mutations to T-cell lymphoblastic lymphoma development
AM Roncero, P López-Nieva, MA Cobos-Fernández, M Villa-Morales, L González-Sánchez, JL López-Lorenzo, P Llamas, C Ayuso, SM Rodríguez-Pinilla, MC Arriba, MA Piris, P Fernández-Navarro, AF Fernández, MF Fraga, J Santos, J Fernández-Piqueras |
Leukemia | 2015 |
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LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia
Y Wang, P Wu, R Lin, L Rong, Y Xue, Y Fang |
Scientific Reports | 2015 |
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Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus
M Mijušković, YF Chou, V Gigi, CR Lindsay, O Shestova, SM Lewis, DB Roth |
Cell Reports | 2015 |
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AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
DM Manesh, J El-Hoss, K Evans, J Richmond, CE Toscan, LS Bracken, A Hedrick, R Sutton, GM Marshall, WR Wilson, RT Kurmasheva, C Billups, PJ Houghton, MA Smith, H Carol, RB Lock |
Blood | 2015 |
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Targeted sequencing identifies associations between IL7R-JAK mutations and epigenetic modulators in T-cell acute lymphoblastic leukemia
C Vicente, C Schwab, M Broux, E Geerdens, S Degryse, S Demeyer, I Lahortiga, A Elliott, L Chilton, RL Starza, C Mecucci, P Vandenberghe, N Goulden, A Vora, AV Moorman, J Soulier, CJ Harrison, E Clappier, J Cools |
Haematologica | 2015 |
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Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case
B Knoechel, A Bhatt, L Pan, CS Pedamallu, E Severson, A Gutierrez, DM Dorfman, FC Kuo, M Kluk, AL Kung, P Zweidler-McKay, M Meyerson, SC Blacklow, DJ DeAngelo, JC Aster |
Molecular Case Studies | 2015 |
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Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?
M Belmonte, C Hoofd, AP Weng, V Giambra |
Current Oncology | 2015 |
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AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair
JB Ford, D Baturin, TM Burleson, AA van Linden, YM Kim, CC Porter |
Oncotarget | 2015 |
|
Targeting IRAK1 in T-cell acute lymphoblastic leukemia
C Dussiau, A Trinquand, L Lhermitte, M Latiri, M Simonin, A Cieslak, N Bedjaoui, P Villarèse, E Verhoeyen, H Dombret, N Ifrah, E Macintyre, V Asnafi |
Oncotarget | 2015 |
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Anti-leukemic effects of the V-ATPase inhibitor Archazolid A.
Zhang S, Schneider LS, Vick B, Grunert M, Jeremias I, Menche D, Müller R, Vollmar AM, Liebl J |
Oncotarget | 2015 |
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Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression
B Uzan, S Poglio, B Gerby, CL Wu, J Gross, F Armstrong, J Calvo, X Cahu, C Deswarte, F Dumont, D Passaro, C Besnard-Guerin, T Leblanc, A Baruchel, J Landman-Parker, P Ballerini, V Baud, J Ghysdael, F Baleydier, F Porteu, F Pflumio |
EMBO Molecular Medicine | 2014 |
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Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia
VL Bentley, CJ Veinotte, DP Corkery, JB Pinder, MA LeBlanc, K Bedard, AP Weng, JN Berman, G Dellaire |
Haematologica | 2014 |
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Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation
JS Blackburn, S Liu, JL Wilder, KP Dobrinski, R Lobbardi, FE Moore, SA Martinez, EY Chen, C Lee, DM Langenau |
Cancer Cell | 2014 |
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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
D Herranz, A Ambesi-Impiombato, T Palomero, SA Schnell, L Belver, AA Wendorff, L Xu, M Castillo-Martin, D Llobet-Navás, C Cordon-Cardo, E Clappier, J Soulier, AA Ferrando |
Nature Medicine | 2014 |
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SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
B Gerby, CS Tremblay, M Tremblay, S Rojas-Sutterlin, S Herblot, J Hébert, G Sauvageau, S Lemieux, E Lécuyer, DF Veiga, T Hoang, HL Grimes, GP Copenhaver |
PLoS genetics | 2014 |
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Cell competition is a tumour suppressor mechanism in the thymus
VC Martins, K Busch, D Juraeva, C Blum, C Ludwig, V Rasche, F Lasitschka, SE Mastitsky, B Brors, T Hielscher, HJ Fehling, HR Rodewald |
Nature | 2014 |
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Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia
C Reynolds, JE Roderick, JL LaBelle, G Bird, R Mathieu, K Bodaar, D Colon, U Pyati, KE Stevenson, J Qi, M Harris, LB Silverman, SE Sallan, JE Bradner, DS Neuberg, AT Look, LD Walensky, MA Kelliher, A Gutierrez |
Leukemia | 2014 |
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Highly aggressive T-cell acute lymphoblastic leukemia with t(8;14)(q24;q11): extensive genetic characterization and achievement of early molecular remission and long-term survival in an adult patient
M Parolini, C Mecucci, C Matteucci, U Giussani, T Intermesoli, M Tosi, A Rambaldi, R Bassan |
Blood Cancer Journal | 2014 |
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Botch Is a γ-Glutamyl Cyclotransferase that Deglycinates and Antagonizes Notch
Z Chi, ST Byrne, A Dolinko, MM Harraz, MS Kim, G Umanah, J Zhong, R Chen, J Zhang, J Xu, L Chen, A Pandey, TM Dawson, VL Dawson |
Cell Reports | 2014 |
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Acute renal failure and type B lactic acidosis as first manifestation of extranodal T-cell lymphoblastic lymphoma
S Yun, CN Walker, ND Vincelette, F Anwer |
BMJ case reports | 2014 |
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Neutrophil Gelatinase-Associated Lipocalin (NGAL), Pro-Matrix Metalloproteinase-9 (pro-MMP-9) and Their Complex Pro-MMP-9/NGAL in Leukaemias
S Bouchet, B Bauvois |
Cancers | 2014 |
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Increased leukemia-associated gene expression in benzene-exposed workers
K Li, Y Jing, C Yang, S Liu, Y Zhao, X He, F Li, J Han, G Li |
Scientific Reports | 2014 |
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Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia
AM Spartà, D Bressanin, F Chiarini, A Lonetti, A Cappellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, JA McCubrey, AM Martelli |
Cell cycle (Georgetown, Tex.) | 2014 |
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Gamma secretase inhibitors enhance vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner
SO Yoon, MC Zapata, A Singh, WS Jo, N Spencer, YS Choi |
Apoptosis | 2014 |
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
I Bartram, N Gökbuget, C Schlee, S Heesch, L Fransecky, S Schwartz, R Stuhlmann, K Schäfer-Eckhart, M Starck, A Reichle, D Hoelzer, CD Baldus, M Neumann |
Journal of Hematology & Oncology | 2014 |
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Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemia
A Efanov, N Zanesi, V Coppola, G Nuovo, B Bolon, D Wernicle-Jameson, A Lagana, A Hansjuerg, F Pichiorri, CM Croce |
Blood Cancer Journal | 2014 |
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When cancer and immunology meet
M Carroll |
Immunological Reviews | 2014 |
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KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo
P Pekkonen, A Järviluoma, N Zinovkina, A Cvrljevic, S Prakash, J Westermarck, GI Evan, E Cesarman, EW Verschuren, PM Ojala |
Cell cycle (Georgetown, Tex.) | 2014 |
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MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia
E Mets, JV der Meulen, GV Peer, M Boice, P Mestdagh, IV de Walle, T Lammens, S Goossens, BD Moerloose, Y Benoit, NV Roy, E Clappier, B Poppe, J Vandesompele, HG Wendel, T Taghon, P Rondou, J Soulier, PV Vlierberghe, F Speleman |
Leukemia | 2014 |
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The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
JV der Meulen, V Sanghvi, K Mavrakis, K Durinck, F Fang, F Matthijssens, P Rondou, M Rosen, T Pieters, P Vandenberghe, E Delabesse, T Lammens, BD Moerloose, B Menten, NV Roy, B Verhasselt, B Poppe, Y Benoit, T Taghon, AM Melnick, F Speleman, HG Wendel, PV Vlierberghe |
Blood | 2014 |
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Cyclin C surprises in tumour suppression
M Trakala, M Malumbres |
Nature Cell Biology | 2014 |
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A Novel Cryptic Three-Way Translocation t(2;9;18)(p23.2;p21.3;q21.33) with Deletion of Tumor Suppressor Genes in 9p21.3 and 13q14 in a T-Cell Acute Lymphoblastic Leukemia
MA Othman, M Rincic, JB Melo, IM Carreira, E Alhourani, F Hunstig, A Glaser, T Liehr |
Leukemia Research and Treatment | 2014 |
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Controlling Pre-leukemic Thymocyte Self-Renewal
S Goossens, PV Vlierberghe, HL Grimes |
PLoS genetics | 2014 |
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The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia
K Durinck, A Wallaert, IV de Walle, WV Loocke, PJ Volders, S Vanhauwaert, E Geerdens, Y Benoit, NV Roy, B Poppe, J Soulier, J Cools, P Mestdagh, J Vandesompele, P Rondou, PV Vlierberghe, T Taghon, F Speleman |
Haematologica | 2014 |
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Single-step Enrichment by Ti4+-IMAC and Label-free Quantitation Enables In-depth Monitoring of Phosphorylation Dynamics with High Reproducibility and Temporal Resolution
EL de Graaf, P Giansanti, AF Altelaar, AJ Heck |
Molecular & cellular proteomics : MCP | 2014 |
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Mutational spectrum of adult T-ALL
Neumann M, Vosberg S, Schlee C, Heesch S, Schwartz S, Gökbuget N, Hoelzer D, Graf A, Krebs S, Bartram I, Blum H, Brüggemann M, Hecht J, Bohlander SK, Greif PA, Baldus CD |
Oncotarget | 2014 |
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MYCN is a novel oncogenic target in pediatric T-cell acute lymphoblastic leukemia.
Astolfi A, Vendemini F, Urbini M, Melchionda F, Masetti R, Franzoni M, Libri V, Serravalle S, Togni M, Paone G, Montemurro L, Bressanin D, Chiarini F, Martelli AM, Tonelli R, Pession A |
Oncotarget | 2014 |
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Low PKCa expression within the MRD-HR stratum defines a new subgroup of childhood T-ALL with very poor outcome
Milani G, Rebora P, Accordi B, Galla L, Bresolin S, Cazzaniga G, Buldini B, Mura R, Ladogana S, Giraldi E, Conter V, Kronnie GT, Valsecchi MG, Basso G |
Oncotarget | 2014 |
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Notch signaling in hematopoietic cell transplantation and T cell alloimmunity
C Ebens, I Maillard |
Blood Reviews | 2013 |
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Disruption of Prostate Epithelial Differentiation Pathways and Prostate Cancer Development
SB Frank, CK Miranti |
Frontiers in Oncology | 2013 |
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Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling
F Buontempo, E Orsini, LR Martins, I Antunes, A Lonetti, F Chiarini, G Tabellini, C Evangelisti, C Evangelisti, F Melchionda, A Pession, A Bertaina, F Locatelli, JA McCubrey, A Cappellini, JT Barata, AM Martelli |
Leukemia | 2013 |
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Mechanisms in Endocrinology: Notch signaling in skeletal health and disease
S Zanotti, E Canalis |
European Journal of Endocrinology | 2013 |
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Applicability of gene expression profile of childhood acute lymphoblastic leukemia at diagnosis and at the end of the induction phase of chemotherapy at a cancer hospital in the state of Goiás (Brazil)
LB Minasi, FR Godoy, D de M. e Silva, TC Vieira, CC da Silva, AD da Cruz |
Tumor Biology | 2013 |
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Par-4/THAP1 complex and Notch3 competitively regulated pre-mRNA splicing of CCAR1 and affected inversely the survival of T-cell acute lymphoblastic leukemia cells
C Lu, JY Li, Z Ge, L Zhang, GP Zhou |
Oncogene | 2013 |
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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia
PV Vlierberghe, A Ambesi-Impiombato, KD Keersmaecker, M Hadler, E Paietta, MS Tallman, JM Rowe, C Forne, M Rue, AA Ferrando |
Blood | 2013 |
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GFI1B, EVI5, MYB—Additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas
BW Baron, J Anastasi, J Bies, PL Reddy, L Joseph, MJ Thirman, K Wroblewski, L Wolff, JM Baron |
Blood Cells, Molecules, and Diseases | 2013 |
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Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia
ZK Atak, V Gianfelici, G Hulselmans, KD Keersmaecker, AG Devasia, E Geerdens, N Mentens, S Chiaretti, K Durinck, A Uyttebroeck, P Vandenberghe, I Wlodarska, J Cloos, R Foà, F Speleman, J Cools, S Aerts |
PLoS genetics | 2013 |
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Acute lymphocitic leukaemia and AIDS
MR Bacci, JA Santos, NC Zing, DM Barros |
BMJ case reports | 2013 |
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Genetics: Written in blood
S DeWeerdt |
Nature | 2013 |
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Lymphoid malignancies: many tumor types, many altered genes, many therapeutic challenges
Riccardo Dalla-Favera |
Journal of Clinical Investigation | 2012 |
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Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
KD Keersmaecker, ZK Atak, N Li, C Vicente, S Patchett, T Girardi, V Gianfelici, E Geerdens, E Clappier, M Porcu, I Lahortiga, R Lucà, J Yan, G Hulselmans, H Vranckx, R Vandepoel, B Sweron, K Jacobs, N Mentens, I Wlodarska, B Cauwelier, J Cloos, J Soulier, A Uyttebroeck, C Bagni, BA Hassan, P Vandenberghe, AW Johnson, S Aerts, J Cools |
Nature Genetics | 2012 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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