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Simon A. Jones, … , Jürgen Scheller, Stefan Rose-John
Published September 1, 2011
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
Citation Information: J Clin Invest. 2011;121(9):3375-3383. https://doi.org/10.1172/JCI57158.
Abstract
The successful treatment of certain autoimmune conditions with the humanized anti–IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflammatory regulator. Attention will be given to the role of the soluble IL-6R, and we will provide a perspective into the clinical blockade of IL-6 activity in autoimmunity, inflammation, and cancer.
Authors
Simon A. Jones, Jürgen Scheller, Stefan Rose-John
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Citation information
Citations to this article (319)
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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis
R Davies, J Williams, K Sime, HS Jin, C Thompson, L Jordan, D Lang, JP Halcox, E Ellins, GW Jones, SA Jones, S Rose-John, A Williams, E Choy |
Rheumatology | 2020 |
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Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival
P Majumder, Y Zhang, M Iglesias, L Fan, JA Kelley, C Andrews, N Patel, JR Stagno, BC Oh, GJ Furtmüller, CC Lai, YX Wang, G Brandacher, G Raimondi, JP Schneider |
Small (Weinheim an Der Bergstrasse, Germany) | 2020 |
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Diagnosis, Screening and Treatment of Patients with Palmoplantar Pustulosis (PPP): A Review of Current Practices and Recommendations E Freitas, MA Rodrigues, T Torres |
Clinical, cosmetic and investigational dermatology | 2020 |
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Association between cytokine profiles and lung injury in COVID-19 pneumonia
LD Chen, ZY Zhang, XJ Wei, YQ Cai, WZ Yao, MH Wang, QF Huang, XB Zhang |
Respiratory Research | 2020 |
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Inhibiting IL-6 in COVID-19: we are not sure
PM Honore, LB Gutierrez, L Kugener, S Redant, R Attou, A Gallerani, DD Bels |
Critical Care | 2020 |
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Interactions among Interleukin-6, C-Reactive Protein and Interleukin-6 (-174) G/C Polymorphism in the Pathogenesis of Crohn’s Disease and Ulcerative Colitis
B Takač |
ACTA CLIN CROAT | 2020 |
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Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study
S Fantone, G Tossetta, R Montironi, M Senzacqua, D Marzioni, R Mazzucchelli |
European Journal of Histochemistry : EJH | 2020 |
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Super-enhancers modulate interleukin-6 expression and function in cancers.
Bao Y, Wu Y, Tao B, Sun R, Lin T, Zheng Y, Zhu X, Shen H, Chen W, Fan Y |
Translational cancer research | 2020 |
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Thermoresponsive, hollow, degradable core-shell nanoparticles for intraarticular delivery of anti-inflammatory peptide
Deloney M, Smart K, Christiansen BA, Panitch A |
Journal of Controlled Release | 2020 |
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IL-33-mediated IL-13 secretion by ST2+ Treg controls inflammation after lung injury
Quan Liu, Gaelen Dwyer, Yifei Zhao, Huihua Li, Lisa Mathews, Anish Bhaswantha Chakka, Uma R. Chandran, Anthony J. Demetris, John Alcorn, Keven Robinson, Luis A Ortiz, Bruce Pitt, Angus W Thomson, Ming-Hui Fan, Timothy R Billiar, Heth R Turnquist |
JCI Insight | 2019 |
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Activated gp130 signaling selectively targets B cell differentiation to induce mature lymphoma and plasmacytoma
Anna K Scherger, Mona Al-Maarri, H. Carlo Maurer, Markus Schick, Sabine Maurer, Rupert Öllinger, Irene Gonzalez-Menendez, Manuela Martella, Markus Thaler, Konstanze Pechloff, Katja Steiger, Sandrine Sander, Jürgen Ruland, Roland Rad, Leticia Quintanilla-Martinez, Frank-Thomas Wunderlich, Stefan Rose-John, Ulrich Keller |
JCI Insight | 2019 |
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Inflammation as a Therapeutic Target in Atherosclerosis
MT Nguyen, S Fernando, N Schwarz, JT Tan, CA Bursill, PJ Psaltis |
Journal of Clinical Medicine | 2019 |
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Therapeutic Targeting of the Proinflammatory IL-6-JAK/STAT Signalling Pathways Responsible for Vascular Restenosis in Type 2 Diabetes Mellitus
FT Moshapa, K Riches-Suman, TM Palmer |
Cardiology Research and Practice | 2019 |
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ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer
Schumacher, RJ |
Cancers | 2019 |
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The Immunobiology of the Interleukin-12 Family: Room for Discovery
ED Wojno, CA Hunter, JS Stumhofer |
Immunity | 2019 |
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Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori
S Backert |
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Increased autocrine interleukin-6 production is significantly associated with worse clinical outcome in patients with chronic lymphocytic leukemia: WANG et al
HQ Wang, L Jia, YT Li, T Farren, SG Agrawal, FT Liu |
Journal of Cellular Physiology | 2019 |
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Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells
S Zhu, M Soutto, Z Chen, MB Piazuelo, MK Washington, A Belkhiri, A Zaika, D Peng, W El-Rifai |
Oncogene | 2019 |
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Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
W Chen, H Yuan, W Cao, T Wang, W Chen, H Yu, Y Fu, B Jiang, H Zhou, H Guo, X Zhao |
Theranostics | 2019 |
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Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heart
T Bise, AS de Preux Charles, A Jaźwińska |
npj Regenerative Medicine | 2019 |
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Novel Antiatherosclerotic Therapies
P Libby, B Everett |
Arteriosclerosis, thrombosis, and vascular biology | 2019 |
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Schistosome infection and its effect on pulmonary circulation
G Butrous |
Global Cardiology Science and Practice | 2019 |
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Circulating Inflammation Proteins Associated With Lung Cancer in African Americans
CL Meaney, KA Mitchell, A Zingone, D Brown, E Bowman, Y Yu, AS Wenzlaff, C Neslund-Dudas, SR Pine, L Cao, AG Schwartz, BM Ryan |
Journal of Thoracic Oncology | 2019 |
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Blocking IL-6/GP130 Signaling Inhibits Cell Viability/Proliferation, Glycolysis, and Colony Forming Activity in Human Pancreatic Cancer Cells
X Chen, J Tian, GH Su, J Lin |
Current cancer drug targets | 2019 |
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Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling
CM Flynn, Y Garbers, J Lokau, D Wesch, DM Schulte, M Laudes, W Lieb, S Aparicio-Siegmund, C Garbers |
Scientific Reports | 2019 |
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Signaling Through gp130 Compromises Suppressive Function in Human FOXP3+ Regulatory T Cells
KB Dhuban, S Bartolucci, E d'Hennezel, CA Piccirillo |
Frontiers in immunology | 2019 |
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17β-Estradiol promotes endometrial cancer proliferation and invasion through IL-6 pathway
Q Che, X Xiao, J Xu, M Liu, Y Lu, S Liu, |
Endocrine Connections | 2019 |
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The Effect of Interleukin-6 (IL-6), Interleukin-11 (IL-11), Signal Transducer and Activator of Transcription 3 (STAT3), and AKT Signaling on Adipocyte Proliferation in a Rat Model of Polycystic Ovary Syndrome
Z Zhuang, X Pan, K Zhao, W Gao, J Liu, T Deng, W Qin |
Medical science monitor : international medical journal of experimental and clinical research | 2019 |
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KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling
Q Zhou, Y Zhang, B Wang, W Zhou, Y Bi, W Huai, , Y Chen, Z Liu, X Liu, Z Zhan |
Cellular and Molecular Immunology | 2019 |
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Deletion of IL-6 Exacerbates Colitis and Induces Systemic Inflammation in IL-10-Deficient Mice
M Ye, ME Joosse, L Liu, Y Sun, Y Dong, C Cai, Z Song, J Zhang, SR Brant, M Lazarev, X Li |
Journal of Crohn's & colitis | 2019 |
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Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances
A Ohradanova-Repic, C Machacek, C Charvet, F Lager, DL Roux, R Platzer, V Leksa, G Mitulovic, TR Burkard, GJ Zlabinger, MB Fischer, V Feuillet, G Renault, S Blüml, M Benko, M Suchanek, JB Huppa, T Matsuyama, A Cavaco-Paulo, G Bismuth, H Stockinger |
Frontiers in immunology | 2018 |
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Interleukin-6 trans-signaling contributes to chronic hypoxia-induced pulmonary hypertension
LD Maston, DT Jones, W Giermakowska, TC Resta, J Ramiro-Diaz, TA Howard, NL Jernigan, L Herbert, AA Maurice, LV Bosc |
Pulmonary circulation | 2018 |
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Modulation of immune responses in lentiviral vector-mediated gene transfer
A Annoni, S Gregori, L Naldini, A Cantore |
Cellular Immunology | 2018 |
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Interleukin-6: designing specific therapeutics for a complex cytokine
C Garbers, S Heink, T Korn, S Rose-John |
Nature Reviews Drug Discovery | 2018 |
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Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers
L Kern, M Mittenbühler, A Vesting, A Ostermann, C Wunderlich, F Wunderlich |
Cancers | 2018 |
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IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression
HS Kim, M Jung, SK Choi, J Woo, YJ Piao, EH Hwang, H Kim, SJ Kim, WK Moon |
Journal of Experimental & Clinical Cancer Research | 2018 |
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Transcriptional network systems in cartilage development and disease
R Nishimura, K Hata, E Nakamura, T Murakami, Y Takahata |
Histochemistry and Cell Biology | 2018 |
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The Effect of Inhalant Organic Dust on Bone Health
JM Carrington, JA Poole |
Current Allergy and Asthma Reports | 2018 |
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Multifaceted Roles of Interleukin-6 in Adipocyte–Breast Cancer Cell Interaction
J Gyamfi, M Eom, JS Koo, J Choi |
Translational oncology | 2018 |
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The role of interleukin‑6‑STAT3 signalling in glioblastoma (Review)
A West, V Tsui, S Stylli, H Nguyen, A Morokoff, A Kaye, R Luwor |
Oncology Letters | 2018 |
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Inhibition of interleukin-6 trans-signaling prevents inflammation and endothelial barrier disruption in retinal endothelial cells
M Valle, J Dworshak, A Sharma, A Ibrahim, M Al-Shabrawey, S Sharma |
Experimental Eye Research | 2018 |
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Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
Q Wang, Z He, M Huang, T Liu, Y Wang, H Xu, H Duan, P Ma, L Zhang, SS Zamvil, J Hidalgo, Z Zhang, DM ORourke, N Dahmane, S Brem, Y Mou, Y Gong, Y Fan |
Nature Communications | 2018 |
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Cytokines, breast cancer stem cells (BCSCs) and chemoresistance
W Chen, Y Qin, S Liu |
Clinical and Translational Medicine | 2018 |
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Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice
J Hu, X Feng, M Valdearcos, D Lutrin, Y Uchida, SK Koliwad, M Maze |
British Journal of Anaesthesia | 2018 |
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Effects of human umbilical cord-derived mesenchymal stem cells on hematologic malignancies
Q Li, Y Pang, T Liu, Y Tang, J Xie, B Zhang, H Chen |
Oncology Letters | 2018 |
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Oral Vaccination with a DNA Vaccine Encoding Capsid Protein of Duck Tembusu Virus Induces Protection Immunity
J Huang, H Shen, R Jia, M Wang, S Chen, D Zhu, M Liu, X Zhao, Q Yang, Y Wu, Y Liu, L Zhang, Z Yin, B Jing, A Cheng |
Viruses | 2018 |
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DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows
Y Zhang, X Wang, Q Jiang, H Hao, Z Ju, C Yang, Y Sun, C Wang, J Zhong, J Huang, H Zhu |
Cell Stress and Chaperones | 2018 |
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IL-27: a double agent in the IL-6 family: IL-27 and IL-6 in inflammatory arthritis
GW Jones, DG Hill, A Cardus, SA Jones |
Clinical & Experimental Immunology | 2018 |
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ATM inhibition prevents interleukin-6 from contributing to the proliferation of glioblastoma cells after ionizing radiation
YC Lim, H Quek, C Offenhäuser, S Fazry, A Boyd, M Lavin, T Roberts, B Day |
Journal of Neuro-Oncology | 2018 |
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ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
S Schmidt, N Schumacher, J Schwarz, S Tangermann, L Kenner, M Schlederer, M Sibilia, M Linder, A Altendorf-Hofmann, T Knösel, ES Gruber, G Oberhuber, J Bolik, A Rehman, A Sinha, J Lokau, P Arnold, AS Cabron, F Zunke, C Becker-Pauly, A Preaudet, P Nguyen, J Huynh, S Afshar-Sterle, AL Chand, J Westermann, PJ Dempsey, C Garbers, D Schmidt-Arras, P Rosenstiel, T Putoczki, M Ernst, S Rose-John |
Journal of Experimental Medicine | 2018 |
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Inducible microRNA-590-5p inhibits host antiviral response by targeting the soluble interleukin-6 (IL6) receptor
Y Zhou, Z Xia, Z Cheng, G Xu, X Yang, S Liu, Y Zhu |
The Journal of biological chemistry | 2018 |
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Type I Interferons regulate susceptibility to inflammation-induced preterm birth
Monica Cappelletti, Pietro Presicce, matthew lawson, simone vanoni, Vandana Chaturvedi, Traci E STANKIEWICZ, isaac harley, Jaclyn McAlees, Daniel Giles, Maria Moreno-Fernandez, cesar rueda, Paranth Senthamarai Kannan, Xiaofei Sun, Rebekah Karns, Kasper Hoebe, edith janssen, Christopher Karp, David Hildeman, Simon Hogan, Suhas Kallapur, Claire Chougnet, Sing Sing Way, Senad DIVANOVIC |
JCI Insight | 2017 |
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A JAK2-binding Long Noncoding RNA Promotes Breast Cancer Brain Metastasis
Shouyu Wang, Ke Liang, Qingsong Hu, Ping Li, Jian Song, Yuedong Yang, Jun Yao, Lingegowda Mangala, Chunlai Li, wenhao Yang, Peter Park, David Hawke, Jianwei Zhou, Yan Zhou, Weiya Xia, Mien-Chie Hung, Jeffrey Marks, Gary Gallick, Gabriel Lopez-Berestein, Elsa Flores, Anil Sood, Suyun Huang, Dihua Yu, Liuqing Yang, chunru lin |
Journal of Clinical Investigation | 2017 |
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Inhibition of STAT3 Signaling Reduces IgA1 Autoantigen Production in IgA Nephropathy
K Yamada, ZQ Huang, M Raska, C Reily, JC Anderson, H Suzuki, H Ueda, Z Moldoveanu, K Kiryluk, Y Suzuki, RJ Wyatt, Y Tomino, AG Gharavi, A Weinmann, BA Julian, CD Willey, J Novak |
Kidney International Reports | 2017 |
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Selected cytokine pathways in rheumatoid arthritis
M Noack, P Miossec |
Seminars in Immunopathology | 2017 |
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Current and emerging therapeutic targets for IBD
MF Neurath |
Nature Reviews Gastroenterology & Hepatology | 2017 |
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The role of interleukin-6 signalling and its therapeutic blockage in skewing the T cell balance in rheumatoid arthritis: IL-6 signalling in rheumatoid arthritis
K Schinnerling, JC Aguillón, D Catalán, L Soto |
Clinical & Experimental Immunology | 2017 |
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Inflammatory Cytokines as Uremic Toxins: “Ni Son Todos Los Que Estan, Ni Estan Todos Los Que Son”
E Castillo-Rodríguez, S Pizarro-Sánchez, A Sanz, A Ramos, M Sanchez-Niño, C Martin-Cleary, B Fernandez-Fernandez, A Ortiz |
Toxins | 2017 |
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Interleukin-6 stimulates Akt and p38 MAPK phosphorylation and fibroblast migration in non-diabetic but not diabetic mice
TN Shen, S Kanazawa, M Kado, K Okada, L Luo, A Hayashi, H Mizuno, R Tanaka, TR Howdieshell |
PloS one | 2017 |
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Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines
M Sen, PA Johnston, NI Pollock, K DeGrave, SC Joyce, ML Freilino, Y Hua, DP Camarco, DA Close, DM Huryn, P Wipf, JR Grandis |
Journal of Chemical Biology | 2017 |
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Identification of Interleukin-27 (IL-27)/IL-27 Receptor Subunit Alpha as a Critical Immune Axis for In Vivo HIV Control
M Ruiz-Riol, D Berdnik, A Llano, B Mothe, C Gálvez, S Pérez-Álvarez, B Oriol-Tordera, A Olvera, S Silva-Arrieta, M Meulbroek, F Pujol, J Coll, J Martinez-Picado, C Ganoza, J Sanchez, G Gómez, T Wyss-Coray, C Brander, JU Jung |
Journal of virology | 2017 |
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Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation
S Riethmueller, P Somasundaram, JC Ehlers, CW Hung, CM Flynn, J Lokau, M Agthe, S Düsterhöft, Y Zhu, J Grötzinger, I Lorenzen, T Koudelka, K Yamamoto, U Pickhinke, R Wichert, C Becker-Pauly, M Rädisch, A Albrecht, M Hessefort, D Stahnke, C Unverzagt, S Rose-John, A Tholey, C Garbers, P Marrack |
PLoS Biology | 2017 |
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NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth
L Chen, JE Wilson, MJ Koenigsknecht, WC Chou, SA Montgomery, AD Truax, WJ Brickey, CD Packey, N Maharshak, GK Matsushima, SE Plevy, VB Young, RB Sartor, JP Ting |
Nature Immunology | 2017 |
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Affibody molecules as engineered protein drugs
FY Frejd, KT Kim |
Experimental & molecular medicine | 2017 |
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Serum sonic hedgehog (SHH) and interleukin-(IL-6) as dual prognostic biomarkers in progressive metastatic breast cancer
AS Noman, M Uddin, AA Chowdhury, MJ Nayeem, Z Raihan, MI Rashid, AK Azad, ML Rahman, D Barua, A Sultana, A Shirin, J Ferdous, RR Parag, SM Rahman, MR Mahmud, CS Jerin, N Jahan, A Siddiqua, T Ara, EB Sabur, SS Alam, S Baidya, S Akther, MZ Rahman, T Banu, AK Murugan, S Sabri, SM Islam, B Karakas, A Aboussekhra, H Yeger, WA Farhat, SS Islam |
Scientific Reports | 2017 |
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Cytokine storm and sepsis disease pathogenesis
BG Chousterman, FK Swirski, GF Weber |
Seminars in Immunopathology | 2017 |
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New fronts emerge in the influenza cytokine storm
XJ Guo, PG Thomas |
Seminars in Immunopathology | 2017 |
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High Fat Diet-Induced Obesity Increases Myocardial Injury and Alters Cardiac STAT3 Signaling in Mice after Polymicrobial Sepsis
T DeMartini, M Nowell, J James, L Williamson, P Lahni, H Shen, JM Kaplan |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 |
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The role of IL-6 in host defence against infections: immunobiology and clinical implications
S Rose-John, K Winthrop, L Calabrese |
Nature Reviews Rheumatology | 2017 |
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Integrating cytokines and angiogenic factors and tumour bulk with selected clinical criteria improves determination of prognosis in advanced renal cell carcinoma
AJ Zurita, RC Gagnon, Y Liu, HT Tran, RA Figlin, TE Hutson, AM D'Amelio, CN Sternberg, LN Pandite, JV Heymach |
British Journal of Cancer | 2017 |
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Repositioning Bazedoxifene as a novel IL-6/GP130 signaling antagonist for human rhabdomyosarcoma therapy
H Xiao, HK Bid, X Chen, X Wu, J Wei, Y Bian, C Zhao, H Li, C Li, J Lin, A Ahmad |
PloS one | 2017 |
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Interleukin-6-dependent growth in a newly established plasmablastic lymphoma cell line and its therapeutic targets
S Mine, T Hishima, A Suganuma, H Fukumoto, Y Sato, M Kataoka, T Sekizuka, M Kuroda, T Suzuki, H Hasegawa, M Fukayama, H Katano |
Scientific Reports | 2017 |
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Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models
TJ Phesse, VM Durban, OJ Sansom |
Carcinogenesis | 2017 |
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Selective effects of non-thermal atmospheric plasma on triple-negative breast normal and carcinoma cells through different cell signaling pathways
Y Liu, S Tan, H Zhang, X Kong, L Ding, J Shen, Y Lan, C Cheng, T Zhu, W Xia |
Scientific Reports | 2017 |
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Treatments for Pulmonary Ricin Intoxication: Current Aspects and Future Prospects
Y Gal, O Mazor, R Falach, A Sapoznikov, C Kronman, T Sabo |
Toxins | 2017 |
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Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition
I Siddiqui, M Erreni, MA Kamal, C Porta, F Marchesi, S Pesce, F Pasqualini, S Schiarea, C Chiabrando, A Mantovani, P Allavena |
OncoImmunology | 2017 |
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Inflammation and cardio-renal interactions in heart failure: a potential role for interleukin-6: Research Letter
JS Hanberg, VS Rao, T Ahmad, Z Chunara, D Mahoney, K Jackson, D Jacoby, M Chen, FP Wilson, WH Tang, R Kakkar, JM Testani |
European Journal of Heart Failure | 2017 |
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Human IL-6R hi TIGIT − CD4 + CD127 low CD25 + T cells display potent in vitro suppressive capacity and a distinct Th17 profile
RC Ferreira, DB Rainbow, AR García, ML Pekalski, L Porter, JJ Oliveira, F Waldron-Lynch, LS Wicker, JA Todd |
Clinical Immunology | 2017 |
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IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo
V Brahmakshatriya, Y Kuang, P Devarajan, J Xia, W Zhang, AM Vong, SL Swain |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
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Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions
A Abdullahi, MG Jeschke |
Endocrine reviews | 2017 |
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Functional interleukin-6 receptor-α is located in tanycytes at the base of the third ventricle
F Anesten, C Santos, E Gidestrand, E Schéle, V Pálsdóttir, T Swedung-Wettervik, B Meister, KP Skibicka, JO Jansson |
Journal of Neuroendocrinology | 2017 |
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A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Tocilizumab, An Interleukin-6 Receptor Antibody, For Residual Symptoms in Schizophrenia
RR Girgis, A Ciarleglio, T Choo, G Haynes, JM Bathon, S Cremers, JT Kantrowitz, JA Lieberman, AS Brown |
Neuropsychopharmacology | 2017 |
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Blocking interleukin-6 signaling inhibits cell viability/proliferation, glycolysis, and colony forming activity of human medulloblastoma cells
X Chen, J Wei, C Li, C Pierson, J Finlay, J Lin |
International journal of oncology | 2017 |
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Delayed revascularization of islets after transplantation by IL-6 blockade in pig to non-human primate islet xenotransplantation model
BH Min, JS Shin, JM Kim, SJ Kang, HJ Kim, IH Yoon, SK Park, J Choi, MS Lee, CG Park |
Xenotransplantation | 2017 |
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Interleukin-6 Family Cytokines
S Rose-John |
Cold Spring Harbor perspectives in biology | 2017 |
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Thiamethoxam induced hepatotoxicity and pro-carcinogenicity in rabbits via motivation of oxidative stress, inflammation, and anti-apoptotic pathway
OS Okle, OI Euony, AF Khafaga, MA Lebda |
Environmental Science and Pollution Research | 2017 |
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Heparanase: From basic research to therapeutic applications in cancer and inflammation
I Vlodavsky, P Singh, I Boyango, L Gutter-Kapon, M Elkin, RD Sanderson, N Ilan |
Drug Resistance Updates | 2016 |
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Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling
J Wolf, GH Waetzig, A Chalaris, TM Reinheimer, H Wege, S Rose-John, C Garbers |
The Journal of biological chemistry | 2016 |
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Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy
X Wu, Y Cao, H Xiao, C Li, J Lin |
Molecular cancer therapeutics | 2016 |
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Role of interleukin-6 in cancer progression and therapeutic resistance
N Kumari, BS Dwarakanath, A Das, AN Bhatt |
Tumor Biology | 2016 |
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Potential therapeutic implications of IL-6/IL-6R/gp130–targeting agents in breast cancer
TH Heo, J Wahler, N Suh |
Oncotarget | 2016 |
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Lost in Trans-IL-6 Signaling: Alveolar Type II Cell Death in Emphysema
I Petrache, K Serban |
American journal of respiratory and critical care medicine | 2016 |
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Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation
J Lokau, M Agthe, C Garbers |
Mediators of Inflammation | 2016 |
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CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer
C Zhang, H Xin, W Zhang, PJ Yazaki, Z Zhang, K Le, W Li, H Lee, L Kwak, S Forman, R Jove, H Yu |
Immunity | 2016 |
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The C/EBPδ protein is stabilized by estrogen receptor α activity, inhibits SNAI2 expression and associates with good prognosis in breast cancer
D Mendoza-Villanueva, K Balamurugan, HR Ali, SR Kim, S Sharan, RC Johnson, AS Merchant, C Caldas, G Landberg, E Sterneck |
Oncogene | 2016 |
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IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3
A Desai, MY Jung, A Olivera, AM Gilfillan, C Prussin, AS Kirshenbaum, MA Beaven, DD Metcalfe |
Journal of Allergy and Clinical Immunology | 2016 |
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Identification of IL-23p19 as an endothelial proinflammatory peptide that promotes gp130-STAT3 signaling
G Espigol-Frigole, E Planas-Rigol, H Ohnuki, O Salvucci, H Kwak, S Ravichandran, B Luke, MC Cid, G Tosato |
Science signaling | 2016 |
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Differentially Expressed miRNAs in Hepatocellular Carcinoma Target Genes in the Genetic Information Processing and Metabolism Pathways
T Thurnherr, WC Mah, Z Lei, Y Jin, SG Rozen, CG Lee |
Scientific Reports | 2016 |
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Antigen distribution of TMUV and GPV are coincident with the expression profiles of CD8α-positive cells and goose IFNγ
H Zhou, S Chen, M Wang, R Jia, D Zhu, M Liu, F Liu, Q Yang, Y Wu, K Sun, X Chen, B Jing, A Cheng |
Scientific Reports | 2016 |
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White Adipose Tissue Browning: A Double-edged Sword
A Abdullahi, MG Jeschke |
Trends in Endocrinology & Metabolism | 2016 |
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Lipoic Acid Exerts Antioxidant and Anti-inflammatory Effects in Response to Heat Shock in C2C12 Myotubes
CT Lee, LC Chang, PF Wu |
Inflammation | 2016 |
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Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17
S Riethmueller, JC Ehlers, J Lokau, S Düsterhöft, K Knittler, G Dombrowsky, J Grötzinger, B Rabe, S Rose-John, C Garbers |
Scientific Reports | 2016 |
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Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies
C Blanchetot, ND Jonge, A Desmyter, N Ongenae, E Hofman, A Klarenbeek, A Sadi, A Hultberg, A Kretz-Rommel, S Spinelli, R Loris, C Cambillau, H Haard |
The Journal of biological chemistry | 2016 |
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Interleukin-6 Is a Risk Factor for Atrial Fibrillation in Chronic Kidney Disease: Findings from the CRIC Study
RL Amdur, M Mukherjee, A Go, IR Barrows, A Ramezani, J Shoji, MP Reilly, J Gnanaraj, R Deo, S Roas, M Keane, S Master, V Teal, EZ Soliman, P Yang, H Feldman, JW Kusek, CM Tracy, DS Raj, AI Aguilera |
PloS one | 2016 |
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Control of ADAM17 activity by regulation of its cellular localisation
I Lorenzen, J Lokau, Y Korpys, M Oldefest, CM Flynn, U Künzel, C Garbers, M Freeman, J Grötzinger, S Düsterhöft |
Scientific Reports | 2016 |
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The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity
K Pierre, N Schlesinger, IP Androulakis |
Physiological genomics | 2016 |
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Benefits of Multifaceted Chemopreventives in the Suppression of the Oral Squamous Cell Carcinoma (OSCC) Tumorigenic Phenotype
SR Mallery, D Wang, B Santiago, P Pei, SP Schwendeman, K Nieto, R Spinney, M Tong, G Koutras, B Han, A Holpuch, J Lang |
Cancer prevention research (Philadelphia, Pa.) | 2016 |
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Macrophage Bone Morphogenic Protein Receptor 2 (BMPR2) depletion in Idiopathic Pulmonary Fibrosis (IPF) and Group III Pulmonary Hypertension
NY Chen, SD Collum, F Luo, T Weng, TT Le, AM Hernandez, K Philip, J Molina, LJ Garcia-Morales, Y Cao, TC Ko, J Amione-Guerra, OA Jabbari, RR Bunge, KA Youker, BA Bruckner, R Hamid, J Davies, N Sinha, H Karmouty-Quintana |
American journal of physiology. Lung cellular and molecular physiology | 2016 |
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Late-breaking abstracts
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United European gastroenterology journal | 2016 |
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Resistin-Like Molecule-β Promotes Invasion and Migration of Gastric Carcinoma Cells
Jiang R, Zhao C, Wang X, Wang S, Sun X, Tian Y, Song W |
Medical science monitor : international medical journal of experimental and clinical research | 2016 |
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IL-6 as a keystone cytokine in health and disease
CA Hunter, SA Jones |
Nature Immunology | 2015 |
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IL-6 Trans-Signaling Drives Murine Crescentic GN
GS Braun, Y Nagayama, Y Maruta, F Heymann, CR van Roeyen, BM Klinkhammer, P Boor, L Villa, DJ Salant, U Raffetseder, S Rose-John, T Ostendorf, J Floege |
Journal of the American Society of Nephrology : JASN | 2015 |
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The Pathogenesis of Cardiomyopathy in Friedreich Ataxia
AH Koeppen, RL Ramirez, AB Becker, ST Bjork, S Levi, P Santambrogio, PJ Parsons, PC Kruger, KX Yang, PJ Feustel, JE Mazurkiewicz, K Pantopoulos |
PloS one | 2015 |
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The Role of the Transcriptional Regulation of Stromal Cells in Chronic Inflammation
A Valin, J Pablos |
Biomolecules | 2015 |
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IL-6 Plays a Crucial Role in HBV Infection
T Lan, L Chang, L Wu, YF Yuan |
Journal of Clinical and Translational Hepatology | 2015 |
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Obesity Is a Positive Modulator of IL-6R and IL-6 Expression in the Subcutaneous Adipose Tissue: Significance for Metabolic Inflammation
S Sindhu, R Thomas, P Shihab, D Sriraman, K Behbehani, R Ahmad, CM Stover |
PloS one | 2015 |
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Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells
W Cao, Y Liu, R Zhang, B Zhang, T Wang, X Zhu, L Mei, H Chen, H Zhang, P Ming, L Huang |
Scientific Reports | 2015 |
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The unusual suspects—innate lymphoid cells as novel therapeutic targets in IBD
R Goldberg, N Prescott, GM Lord, TT MacDonald, N Powell |
Nature Reviews Gastroenterology & Hepatology | 2015 |
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Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model
M Hatting, M Spannbauer, J Peng, MA Masaoudi, G Sellge, YA Nevzorova, N Gassler, C Liedtke, FJ Cubero, C Trautwein |
Cell Death and Disease | 2015 |
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Emerging cytokine networks in colorectal cancer
NR West, S McCuaig, F Franchini, F Powrie |
Nature Reviews Immunology | 2015 |
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The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development
WW Lin, Z Yi, LL Stunz, CJ Maine, LA Sherman, GA Bishop |
Science signaling | 2015 |
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Using gene therapy to manipulate the immune system in the fight against B-cell leukemias
DC Bouhassira, JJ Thompson, ML Davila |
Expert Opinion on Biological Therapy | 2015 |
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Immunosuppressive effects of Amblyomma cajennense tick saliva on murine bone marrow-derived dendritic cells
TM Carvalho-Costa, MT Mendes, MV da Silva, TA da Costa, MG Tiburcio, AC Anhê, V Rodrigues, CJ Oliveira |
Parasites & vectors | 2015 |
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Nickel Ions Selectively Inhibit Lipopolysaccharide-Induced Interleukin-6 Production by Decreasing Its mRNA Stability
S Asakawa, Y Kishimoto, T Takano, K Okita, S Takakuwa, T Sato, M Hiratsuka, O Takeuchi, N Hirasawa, P Proost |
PloS one | 2015 |
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Loss of the Polarity Protein PAR3 Activates STAT3 Signaling via an Atypical Protein Kinase C (aPKC)/NF-κB/Interleukin-6 (IL-6) Axis in Mouse Mammary Cells
RA Guyer, IG Macara |
The Journal of biological chemistry | 2015 |
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Rheumatoid arthritis: IL-6 inhibition in RA—déjà vu all over again?
EM Ruderman |
Nature Reviews Rheumatology | 2015 |
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Inhibition of IL-6 Signaling Pathway by Curcumin in Uterine Decidual Cells
YS Devi, M DeVine, J DeKuiper, S Ferguson, AT Fazleabas, A Croy |
PloS one | 2015 |
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Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN
M Luig, MA Kluger, B Goerke, M Meyer, A Nosko, I Yan, J Scheller, HW Mittrucker, S Rose-John, RA Stahl, U Panzer, OM Steinmetz |
Journal of the American Society of Nephrology : JASN | 2015 |
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Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer
C Bilir, H Engin, M Can, S Likhan, D Demirtas, F Kuzu, T Bayraktaroglu |
Oncology Letters | 2015 |
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Interferon-Beta Therapy of Multiple Sclerosis Patients Improves the Responsiveness of T Cells for Immune Suppression by Regulatory T Cells
B Trinschek, F Luessi, C Gross, H Wiendl, H Jonuleit |
International journal of molecular sciences | 2015 |
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HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines
PA Johnston, M Sen, Y Hua, DP Camarco, TY Shun, JS Lazo, GM Wilson, LO Resnick, MG LaPorte, P Wipf, DM Huryn, JR Grandis |
ASSAY and Drug Development Technologies | 2015 |
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Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies
BD Paepe, J Zschüntzsch |
International journal of molecular sciences | 2015 |
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Inflammation in acute and chronic pancreatitis:
A Habtezion |
Current Opinion in Gastroenterology | 2015 |
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IL-6-driven STAT signalling in circulating CD4+ lymphocytes is a marker for early anticitrullinated peptide antibody-negative rheumatoid arthritis
AE Anderson, AG Pratt, MA Sedhom, JP Doran, C Routledge, B Hargreaves, PM Brown, KA Cao, JD Isaacs, R Thomas |
Annals of the rheumatic diseases | 2015 |
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Prognostic value of interleukin-6 and interleukin-6 receptor in organ-confined clear-cell renal cell carcinoma: a 5-year conditional cancer-specific survival analysis
Q Fu, Y Chang, H An, H Fu, Y Zhu, L Xu, W Zhang, J Xu |
British Journal of Cancer | 2015 |
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Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer
R Bharti, G Dey, PK Ojha, S Rajput, SK Jaganathan, R Sen, M Mandal |
Oncogene | 2015 |
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Prognostic and clinicopathological significance of serum interleukin-6 expression in colorectal cancer: a systematic review and meta-analysis
Z Wang, P Wu, D Wu, Z Zhang, G Hu, Y Lai, J Huang, S Zhao |
OncoTargets and therapy | 2015 |
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A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/Jak2/Stat3 pathway.
Zhao H, Guo Y, Li S, Han R, Ying J, Zhu H, Wang Y, Yin L, Han Y, Sun L, Wang Z, Lin Q, Bi X, Jiao Y, Jia H, Zhao J, Huang Z, Li Z, Zhou J, Song W, Meng K, Cai J |
Oncotarget | 2015 |
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Blockade of IL-6 Trans Signaling Attenuates Pulmonary Fibrosis
TT Le, H Karmouty-Quintana, E Melicoff, TT Le, T Weng, NY Chen, M Pedroza, Y Zhou, J Davies, K Philip, J Molina, F Luo, AT George, LJ Garcia-Morales, RR Bunge, BA Bruckner, M Loebe, H Seethamraju, SK Agarwal, MR Blackburn |
Journal of immunology (Baltimore, Md. : 1950) | 2014 |
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Alternative Intronic Polyadenylation Generates the Interleukin-6 Trans-signaling Inhibitor sgp130-E10
J Sommer, C Garbers, J Wolf, A Trad, JM Moll, M Sack, R Fischer, J Grotzinger, GH Waetzig, DM Floss, J Scheller |
The Journal of biological chemistry | 2014 |
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Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression
J Williams, K Munro, T Palmer |
Cells | 2014 |
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Interleukin-6 signaling drives fibrosis in unresolved inflammation
CA Fielding, GW Jones, RM McLoughlin, L McLeod, VJ Hammond, J Uceda, AS Williams, M Lambie, TL Foster, CT Liao, CM Rice, CJ Greenhill, CS Colmont, E Hams, B Coles, A Kift-Morgan, Z Newton, KJ Craig, JD Williams, GT Williams, SJ Davies, IR Humphreys, VB O'Donnell, PR Taylor, BJ Jenkins, N Topley, SA Jones |
Immunity | 2014 |
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IL-6 as a Druggable Target in Psoriasis: Focus on Pustular Variants
A Saggini, S Chimenti, A Chiricozzi |
Journal of Immunology Research | 2014 |
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Interleukins in chronic liver disease: lessons learned from experimental mouse models
L Hammerich, F Tacke |
Clinical and experimental gastroenterology | 2014 |
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The different shades of fat
V Peirce, S Carobbio, A Vidal-Puig |
Nature | 2014 |
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions
H Yu, H Lee, A Herrmann, R Buettner, R Jove |
Nature Reviews Cancer | 2014 |
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Macrophage Polarization in Pancreatic Carcinoma: Role of Heparanase Enzyme
E Hermano, A Meirovitz, K Meir, G Nussbaum, L Appelbaum, T Peretz, M Elkin |
JNCI Journal of the National Cancer Institute | 2014 |
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Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
W Zhang, N Nandakumar, Y Shi, M Manzano, A Smith, G Graham, S Gupta, EE Vietsch, SZ Laughlin, M Wadhwa, M Chetram, M Joshi, F Wang, B Kallakury, J Toretsky, A Wellstein, C Yi |
Science signaling | 2014 |
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Ectopic lymphoid-like structures in infection, cancer and autoimmunity
C Pitzalis, GW Jones, M Bombardieri, SA Jones |
Nature Reviews Immunology | 2014 |
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Therapeutic effect of farnesylthiosalicylic acid on adjuvant-induced arthritis through suppressed release of inflammatory cytokines: FTS and arthritis
E Aizman, E Blacher, O Ben-Moshe, T Kogan, Y Kloog, A Mor |
Clinical & Experimental Immunology | 2014 |
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Interleukin-6 Signaling, Soluble Glycoprotein 130, and Inflammation in Heart Failure
ET Askevold, L Gullestad, CP Dahl, A Yndestad, T Ueland, P Aukrust |
Current Heart Failure Reports | 2014 |
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PADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation
S Kolodziej, ON Kuvardina, T Oellerich, J Herglotz, I Backert, N Kohrs, E Buscató, SK Wittmann, G Salinas-Riester, H Bonig, M Karas, H Serve, E Proschak, J Lausen |
Nature Communications | 2014 |
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Chemically modified DNA aptamers bind interleukin-6 with high affinity and inhibit signaling by blocking its interaction with interleukin-6 receptor
S Gupta, M Hirota, SM Waugh, I Murakami, T Suzuki, M Muraguchi, M Shibamori, Y Ishikawa, TC Jarvis, JD Carter, C Zhang, B Gawande, M Vrkljan, N Janjic, DJ Schneider |
The Journal of biological chemistry | 2014 |
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IL-6 biology: implications for clinical targeting in rheumatic disease
LH Calabrese, S Rose-John |
Nature Reviews Rheumatology | 2014 |
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Suppression of mucin 2 promotes interleukin-6 secretion and tumor growth in an orthotopic immune-competent colon cancer animal model
YS Shan, HP Hsu, MD Lai, MC Yen, JH Fang, TY Weng, YL Chen |
Oncology reports | 2014 |
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Toll-like Receptor-Mediated Responses by Placental Hofbauer Cells (HBCs): A Potential Pro-Inflammatory Role for Fetal M2 Macrophages
OM Young, Z Tang, T Niven-Fairchild, S Tadesse, G Krikun, ER Norwitz, G Mor, VM Abrahams, S Guller |
American Journal of Reproductive Immunology | 2014 |
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Discovery and characterization of olokizumab: A humanized antibody targeting interleukin-6 and neutralizing gp130-signaling
S Shaw, T Bourne, C Meier, B Carrington, R Gelinas, A Henry, A Popplewell, R Adams, T Baker, S Rapecki, D Marshall, A Moore, H Neale, A Lawson |
mAbs | 2014 |
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Peripheral Nerve Regeneration and NGF-Dependent Neurite Outgrowth of Adult Sensory Neurons Converge on STAT3 Phosphorylation Downstream of Neuropoietic Cytokine Receptor gp130
S Quarta, BE Baeumer, N Scherbakov, M Andratsch, S Rose-John, G Dechant, CE Bandtlow, M Kress |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2014 |
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A Disintegrin and Metalloprotease 17 Dynamic Interaction Sequence, the Sweet Tooth for the Human Interleukin 6 Receptor
S Düsterhöft, K Höbel, M Oldefest, J Lokau, GH Waetzig, A Chalaris, C Garbers, J Scheller, S Rose-John, I Lorenzen, J Grötzinger |
The Journal of biological chemistry | 2014 |
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Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation
L Gu, P Talati, P Vogiatzi, AL Romero-Weaver, J Abdulghani, Z Liao, B Leiby, DT Hoang, T Mirtti, K Alanen, M Zinda, D Huszar, MT Nevalainen |
Molecular cancer therapeutics | 2014 |
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Control and consequences of IL-6 receptor ectodomain shedding
Scheller J |
European Journal of Medical Research | 2014 |
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Clinical effects of soluble interleukin-6 receptor detection on autoimmune rheumatic disease patients
Chen M, Xu MH, Sun CX, Zhang Z, Du Y |
Pakistan Journal of Medical Sciences | 2014 |
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Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation
Aparicio-Siegmund S, Sommer J, Monhasery N, Schwanbeck R, Keil E, Finkenstädt D, Pfeffer K, Rose-John S, Scheller J, Garbers C |
Oncotarget | 2014 |
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Nod2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer
Aurélie Couturier-Maillard, Thomas Secher, Ateequr Rehman, Sylvain Normand, Adele De Arcangelis, Robert Häsler, Ludovic Huot, Teddy Grandjean, Aude Bressenot, Anne Delanoye-Crespin, Olivier Gaillot, Stefan Schreiber, Yves Lemoine, Bernhard RYFFEL, David Hot, Gabriel Nunez, Grace Chen, Philip Rosenstiel, Mathias Chamaillard |
Journal of Clinical Investigation | 2013 |
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IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality
Hong Zhang, Patrick Neuhöfer, Liang Song, Björn Rabe, Marina Lesina, Magdalena U. Kurkowski, Matthias Treiber, Thomas Wartmann, Sara Regner, Henrik Thorlacius, Dieter Saur, Gregor Weirich, Akihiko Yoshimura, Walter Halangk, Joseph Mizgerd, Roland M. Schmid, Stefan Rose-John, Hana Algul |
Journal of Clinical Investigation | 2013 |
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Critical role of STAT3 in IL-6-mediated drug resistance in human neuroblastoma
T Ara, R Nakata, MA Sheard, H Shimada, R Buettner, SG Groshen, L Ji, H Yu, R Jove, RC Seeger, YA DeClerck |
Cancer research | 2013 |
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New targets for mucosal healing and therapy in inflammatory bowel diseases
MF Neurath |
Mucosal Immunology | 2013 |
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Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology
SN Lauder, E Jones, K Smart, A Bloom, AS Williams, JP Hindley, B Ondondo, PR Taylor, M Clement, C Fielding, AJ Godkin, SA Jones, AM Gallimore |
European Journal of Immunology | 2013 |
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A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors
SJ Sohn, K Barrett, AV Abbema, C Chang, PB Kohli, H Kanda, J Smith, Y Lai, A Zhou, B Zhang, W Yang, K Williams, C Macleod, CA Hurley, JJ Kulagowski, N Lewin-Koh, HS Dengler, AR Johnson, N Ghilardi, M Zak, J Liang, WS Blair, S Magnuson, LC Wu |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Imbalanced frequencies of Th17 and Treg cells in acute coronary syndromes are mediated by IL-6-STAT3 signaling
Y Ma, X Yuan, L Deng, W Xu, Y Zheng, C Yue, G Zhang, F Xie, YH Yang, MP Gantier, JP Liu, D Xu, L Shen |
PloS one | 2013 |
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Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)
C Garbers, F Kuck, S Aparicio-Siegmund, K Konzak, M Kessenbrock, A Sommerfeld, D Häussinger, PA Lang, D Brenner, TW Mak, S Rose-John, F Essmann, K Schulze-Osthoff, RP Piekorz, J Scheller |
Cell cycle (Georgetown, Tex.) | 2013 |
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Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis
B Trinschek, F Luessi, F Lüssi, J Haas, B Wildemann, F Zipp, H Wiendl, C Becker, H Jonuleit |
PloS one | 2013 |
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Stabilized Interleukin-6 receptor binding RNA aptamers
C Meyer, K Berg, K Eydeler-Haeder, I Lorenzen, J Grötzinger, S Rose-John, U Hahn |
RNA biology | 2013 |
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miR-203, a Tumor Suppressor Frequently Down-regulated by Promoter Hypermethylation in Rhabdomyosarcoma
Y Diao, X Guo, L Jiang, G Wang, C Zhang, J Wan, Y Jin, Z Wu |
The Journal of biological chemistry | 2013 |
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Metalloproteinases and their natural inhibitors in inflammation and immunity
R Khokha, A Murthy, A Weiss |
Nature Reviews Immunology | 2013 |
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Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts
A Lee, Y Qiao, G Grigoriev, J Chen, KH Park-Min, SH Park, LB Ivashkiv, GD Kalliolias |
Arthritis & Rheumatism | 2013 |
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Interleukin-6: a new therapeutic target in systemic sclerosis?
S O'Reilly, R Cant, M Ciechomska, JM van Laar |
IBMS BoneKEy | 2013 |
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Inflammation and liver tumorigenesis
B Sun, M Karin |
Frontiers of Medicine | 2013 |
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The problem of choice: current biologic agents and future prospects in RA
EH Choy, AF Kavanaugh, SA Jones |
Nature Reviews Rheumatology | 2013 |
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Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy
Y Makuuchi, K Honda, Y Osaka, K Kato, T Kojima, H Daiko, H Igaki, Y Ito, S Hoshino, S Tachibana, T Watanabe, K Furuta, S Sekine, T Umaki, Y Watabe, N Miura, M Ono, A Tsuchida, T Yamada |
Cancer Science | 2013 |
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Serum levels of IL-6 and IL-1β can predict the efficacy of gemcitabine in patients with advanced pancreatic cancer
S Mitsunaga, M Ikeda, S Shimizu, I Ohno, J Furuse, M Inagaki, S Higashi, H Kato, K Terao, A Ochiai |
British Journal of Cancer | 2013 |
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Impact of interleukin-6 in hematological malignancies
R Burger |
Transfusion Medicine and Hemotherapy | 2013 |
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Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys
A Thanou, JT Merrill |
Nature Reviews Rheumatology | 2013 |
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Tocilizumab: A Review of Its Use in the Treatment of Juvenile Idiopathic Arthritis
JE Frampton |
Pediatric Drugs | 2013 |
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The 2013 ACR meeting: mad macs at the Marina
DS Pisetsky |
Arthritis Research & Therapy | 2013 |
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Juzentaihoto Failed to Augment Antigen-Specific Immunity but Prevented Deterioration of Patients' Conditions in Advanced Pancreatic Cancer under Personalized Peptide Vaccine
S Yutani, N Komatsu, S Matsueda, M Yoshitomi, T Shirahama, A Yamada, K Itoh, T Sasada |
Evidence-Based Complementary and Alternative Medicine | 2013 |
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Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
RC Ferreira, DF Freitag, AJ Cutler, JM Howson, DB Rainbow, DJ Smyth, S Kaptoge, P Clarke, C Boreham, RM Coulson, ML Pekalski, WM Chen, S Onengut-Gumuscu, SS Rich, AS Butterworth, A Malarstig, J Danesh, JA Todd |
PLoS genetics | 2013 |
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Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling
P Baran, R Nitz, J Grötzinger, J Scheller, C Garbers |
The Journal of biological chemistry | 2013 |
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IL-6-Mediated Induction of Matrix Metalloproteinase-9 Is Modulated by JAK-Dependent IL-10 Expression in Macrophages
P Kothari, R Pestana, R Mesraoua, R Elchaki, KM Khan, AJ Dannenberg, DJ Falcone |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
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Modulation of inflammation by interleukin-27
M Bosmann, PA Ward |
Journal of leukocyte biology | 2013 |
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How Cytokine Networks Fuel Inflammation: Toward a cytokine-based disease taxonomy
G Schett, D Elewaut, IB McInnes, JM Dayer, MF Neurath |
Nature Medicine | 2013 |
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Phase II study of personalized peptide vaccination for refractory bone and soft tissue sarcoma patients
R Takahashi, Y Ishibashi, K Hiraoka, S Matsueda, K Kawano, A Kawahara, M Kage, K Ohshima, R Yamanaka, S Shichijo, K Shirouzu, K Itoh, T Sasada |
Cancer Science | 2013 |
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Leptin and mucosal immunity
NM Mackey-Lawrence, WA Petri |
Mucosal Immunology | 2012 |
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Targeting interleukin-6: all the way to treat autoimmune and inflammatory diseases
T Tanaka, T Kishimoto |
International journal of biological sciences | 2012 |
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Innate Immune Cells in Liver Inflammation
E Liaskou, DV Wilson, YH Oo |
Mediators of Inflammation | 2012 |
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Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
S Vicent, LC Sayles, D Vaka, P Khatri, O Gevaert, R Chen, Y Zheng, AK Gillespie, N Clarke, Y Xu, J Shrager, CD Hoang, S Plevritis, AJ Butte, EA Sweet-Cordero |
Cancer research | 2012 |
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Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?
C Finelli, G Tarantino |
World journal of gastroenterology : WJG | 2012 |
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HHV-8-encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice
J Suthaus, C Stuhlmann-Laeisz, VS Tompkins, TR Rosean, W Klapper, G Tosato, S Janz, J Scheller, S Rose-John |
Blood | 2012 |
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Cardiovascular risk biomarkers in CKD: the inflammation link and the road less traveled
U Elewa, MD Sanchez-Niño, C Martin-Cleary, B Fernandez-Fernandez, J Egido, A Ortiz |
International Urology and Nephrology | 2012 |
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Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer
C Johnson, Y Han, N Hughart, J McCarra, G Alpini, F Meng |
Translational gastrointestinal cancer | 2012 |
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A designer hyper interleukin 11 (H11) is a biologically active cytokine
H Dams-Kozlowska, K Gryska, E Kwiatkowska-Borowczyk, D Izycki, S Rose-John, A Mackiewicz |
BMC Biotechnology | 2012 |
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The Stress-Induced Cytokine Interleukin-6 Decreases the Inhibition/Excitation Ratio in the Rat Temporal Cortex via Trans-Signaling
F Garcia-Oscos, H Salgado, S Hall, F Thomas, GE Farmer, J Bermeo, LC Galindo, RD Ramirez, S D'Mello, S Rose-John, M Atzori |
Biological Psychiatry | 2012 |
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JAK/STAT3 pathway inhibition blocks skeletal muscle wasting downstream of IL-6 and in experimental cancer cachexia
A Bonetto, T Aydogdu, X Jin, Z Zhang, R Zhan, L Puzis, LG Koniaris, TA Zimmers |
American journal of physiology. Endocrinology and metabolism | 2012 |
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Interleukin-6, a major cytokine in the central nervous system
M Erta, A Quintana, J Hidalgo |
International journal of biological sciences | 2012 |
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d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers
E Magbanua, T Zivkovic, B Hansen, N Beschorner, C Meyer, I Lorenzen, J Grötzinger, J Hauber, AE Torda, G Mayer, S Rose-John, U Hahn |
RNA biology | 2012 |
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Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3
KW Park, SE Nozell, EN Benveniste |
PloS one | 2012 |
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An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer
C Garbers, B Spudy, S Aparicio-Siegmund, GH Waetzig, J Sommer, C Hölscher, S Rose-John, J Grötzinger, I Lorenzen, J Scheller |
The Journal of biological chemistry | 2012 |
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Interleukin-6--a key regulator of colorectal cancer development
MJ Waldner, S Foersch, MF Neurath |
International journal of biological sciences | 2012 |
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IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6
S Rose-John |
International journal of biological sciences | 2012 |
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Influence of hypothalamic IL-6/gp130 receptor signaling on the HPA axis response to chronic stress
M Girotti, JJ Donegan, DA Morilak |
Psychoneuroendocrinology | 2012 |
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Role of inflammatory cytokines in peripheral nerve injury
Federica Fregnan, Federica Fregnan, Luisa Muratori, Luisa Muratori, Anabel Rodriguez Simões, Maria Giuseppina Giacobini-Robecchi, Stefania Raimondo |
Neural Regeneration Research | 2012 |
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New insights into the role and signalling processes of gp130
Rose-John S |
Arthritis Research & Therapy | 2011 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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