The discovery that certain high-risk strains of human papillomavirus (HR-HPV) cause nearly 100% of invasive cervical cancer has spurred a revolution in cervical cancer prevention by promoting the development of viral vaccines. Although the efficacy of these vaccines has already been demonstrated, a complete understanding of viral latency and natural immunity is lacking, and solving these mysteries could help guide policies of cervical cancer screening and vaccine use. Here, we examine the epidemiological and biological understanding of the natural history of HPV infection, with an eye toward using these studies to guide the implementation of cervical cancer prevention strategies.
Patti E. Gravitt
Title and authors | Publication | Year |
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The CXCL12/CXCR4 Signaling Pathway: A New Susceptibility Factor in Human Papillomavirus Pathogenesis
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PLoS pathogens | 2016 |
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Cancer Medicine | 2016 |
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Medical Microbiology and Immunology | 2016 |
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International Journal of Cancer | 2016 |
Human Papillomavirus DNA Detection in Older Women—Implications for Cancer Screening and Prevention
AC Ermel, KH Fife |
The Journal of Infectious Diseases | 2016 |
Pre-vaccine era cervical human papillomavirus infection among screening population of women in west Austria
W Borena, M Grünberger, A Widschwendter, KH Kraxner, E Marth, P Mayr, J Meier, N Ruth, AT Guerrero, C Marth, DH Laer |
BMC Public Health | 2016 |
Similar Risk Patterns After Cervical Screening in Two Large U.S. Populations: Implications for Clinical Guidelines
JC Gage, WC Hunt, M Schiffman, HA Katki, LA Cheung, O Myers, J Cuzick, N Wentzensen, W Kinney, PE Castle, CM Wheeler |
Obstetrics & Gynecology | 2016 |
Trends and determinants of human papillomavirus concordance among HIV-positive and HIV-negative heterosexual couples in Rakai, Uganda
MK Grabowski, PE Gravitt, RH Gray, D Serwadda, AD Redd, G Kigozi, X Kong, F Nalugoda, MJ Wawer, TC Quinn, AA Tobian |
The Journal of Infectious Diseases | 2016 |
O-linked N-acetylglucosamine transferase promotes cervical cancer tumorigenesis through human papillomaviruses E6 and E7 oncogenes
M Kim, YS Kim, H Kim, MY Kang, J Park, DH Lee, GS Roh, HJ Kim, SS Kang, GJ Cho, JK Park, JW Cho, JK Shin, WS Choi |
Oncotarget | 2016 |