The discovery that certain high-risk strains of human papillomavirus (HR-HPV) cause nearly 100% of invasive cervical cancer has spurred a revolution in cervical cancer prevention by promoting the development of viral vaccines. Although the efficacy of these vaccines has already been demonstrated, a complete understanding of viral latency and natural immunity is lacking, and solving these mysteries could help guide policies of cervical cancer screening and vaccine use. Here, we examine the epidemiological and biological understanding of the natural history of HPV infection, with an eye toward using these studies to guide the implementation of cervical cancer prevention strategies.
Patti E. Gravitt
Title and authors | Publication | Year |
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High-Risk Oral Human Papillomavirus Load in the US Population, National Health and Nutrition Examination Survey 2009-2010
AK Chaturvedi, BI Graubard, RK Pickard, W Xiao, ML Gillison |
The Journal of Infectious Diseases | 2014 |
Immunologic treatments for precancerous lesions and uterine cervical cancer
P Vici, L Mariani, L Pizzuti, D Sergi, LD Lauro, E Vizza, F Tomao, S Tomao, C Cavallotti, F Paolini, A Venuti |
Journal of Experimental & Clinical Cancer Research | 2014 |
Seroprevalence of 8 Oncogenic Human Papillomavirus Genotypes and Acquired Immunity Against Reinfection
L Wilson, M Pawlita, PE Castle, T Waterboer, V Sahasrabuddhe, PE Gravitt, M Schiffman, N Wentzensen |
The Journal of Infectious Diseases | 2014 |
Six-Month Incidence and Persistence of Oral HPV Infection in HIV-Negative and HIV-Infected Men Who Have Sex with Men
SH Mooij, HJ Boot, AG Speksnijder, CJ Meijer, AJ King, DW Verhagen, HJ de Vries, WG Quint, A Molijn, MN de Koning, MA van der Sande, MF van der Loeff |
PloS one | 2014 |
The impact of HPV female immunization in Italy: model based predictions
G Guzzetta, L Faustini, D Panatto, R Gasparini, P Manfredi |
PloS one | 2014 |
Cervical cancer screening in older women: new evidence and knowledge gaps
AF Rositch, MI Silver, PE Gravitt |
PLoS Medicine | 2014 |
Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection: Risks after enrollment versus newly detected HPV
JC Gage, HA Katki, M Schiffman, B Fetterman, NE Poitras, T Lorey, LC Cheung, PE Castle, WK Kinney |
International Journal of Cancer | 2014 |
Vaccination against HPV-Associated Neoplasias
G Gross, N Becker, N Brockmeyer, S Esser, U Freitag, M Gebhardt, L Gissmann, P Hillemanns, H Grundhewer, H Ikenberg, H Jessen, A Kaufmann, S Klug, J Klußmann, A Nast, D Pathirana, K Petry, H Pfister, U Röllinghof, P Schneede, A Schneider, E Selka, S Singer, S Smola, B Sporbeck, MK Doeberitz, P Wutzler |
Geburtshilfe und Frauenheilkunde | 2014 |
HPV and anal cancer in HIV-infected individuals: a review.
Schim van der Loeff MF, Mooij SH, Richel O, de Vries HJ, Prins JM |
Current HIV/AIDS Reports | 2014 |
Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men
Machado AP, Gatto de Almeida F, Bonin CM, Martins Prata TT, Sobrinho Ávilla L, Junqueira Padovani CT, Teixeira Ferreira AM, dos Santos Fernandes CE, Tozetti IA |
The Brazilian Journal of Infectious Diseases | 2014 |