Breast cancer, rather than constituting a monolithic entity, comprises heterogeneous tumors with different clinical characteristics, disease courses, and responses to specific treatments. Tumor-intrinsic features, including classical histological and immunopathological classifications as well as more recently described molecular subtypes, separate breast tumors into multiple groups. Tumor-extrinsic features, including microenvironmental configuration, also have prognostic significance and further expand the list of tumor-defining variables. A better understanding of the features underlying heterogeneity, as well as of the mechanisms and consequences of their interactions, is essential to improve targeting of existing therapies and to develop novel agents addressing specific combinations of features.
Nicholas R. Bertos, Morag Park
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Clinical and Translational Medicine | 2024 |
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Cancers | 2024 |
A retrospective cohort study to evaluate disease burden, health care resource utilization, and costs in patients with breast cancer in Dubai, UAE
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BMC health services research | 2024 |
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
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Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 2023 |
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BMC bioinformatics | 2023 |
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Cancer Medicine | 2023 |
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Cancers | 2022 |
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Cancers | 2022 |
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PloS one | 2021 |
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World journal of clinical oncology | 2021 |
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Cancers | 2020 |
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Oncotarget | 2019 |
The Detection and Morphological Analysis of Circulating Tumor and Host Cells in Breast Cancer Xenograft Models
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Cells | 2019 |
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Molecules (Basel, Switzerland) | 2019 |
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Molecular Oncology | 2019 |
Image-based Classification of Tumor Type and Growth Rate using Machine Learning: a preclinical study
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Scientific Reports | 2019 |
In Vitro and In Vivo Study on the Effect of Lysosome-associated Protein Transmembrane 4 Beta on the Progression of Breast Cancer
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Journal of Breast Cancer | 2019 |
Association between MRI background parenchymal enhancement and lymphovascular invasion and estrogen receptor status in invasive breast cancer
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British Journal of Radiology | 2019 |
Response to immunohistochemical markers' conversion after neoadjuvant chemotherapy in breast cancer patients: association between imaging and histopathologic analysis.
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Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico | 2019 |
Breast cancer stem cells and the challenges of eradication: a review of novel therapies
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Stem Cell Investigation | 2018 |
Stromal PTEN determines mammary epithelial response to radiotherapy
GM Sizemore, S Balakrishnan, KA Thies, AM Hammer, ST Sizemore, AJ Trimboli, MC Cuitiño, SA Steck, G Tozbikian, RD Kladney, N Shinde, M Das, D Park, S Majumder, S Krishnan, L Yu, SA Fernandez, A Chakravarti, PG Shields, JR White, LD Yee, TJ Rosol, T Ludwig, M Park, G Leone, MC Ostrowski |
Nature Communications | 2018 |
Breast cancer identification via modeling of peripherally circulating miRNAs
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PeerJ | 2018 |
Breast Cancer Heterogeneity: A focus on Epigenetics and In Vitro 3D Model Systems
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Cell Journal (Yakhteh) | 2018 |
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
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Nature Communications | 2018 |
Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration
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Scientific Reports | 2017 |
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EBioMedicine | 2016 |
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Journal of Developmental Biology | 2016 |
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Bioscience Reports | 2016 |
Proteogenomics connects somatic mutations to signalling in breast cancer
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Nature | 2016 |
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Oncogene | 2016 |
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American Journal of Epidemiology | 2016 |
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Stem Cell Reports | 2016 |
HER2 intratumoral heterogeneity analyses by concurrent HER2 gene and protein assessment for the prognosis of HER2 negative invasive breast cancer patients
S Kurozumi, M Padilla, M Kurosumi, H Matsumoto, K Inoue, J Horiguchi, I Takeyoshi, T Oyama, J Ranger-Moore, DC Allred, E Dennis, H Nitta |
Breast Cancer Research and Treatment | 2016 |
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D Netanely, A Avraham, A Ben-Baruch, E Evron, R Shamir |
Breast Cancer Research | 2016 |
Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells
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International journal of molecular sciences | 2016 |
Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
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Breast cancer : targets and therapy | 2016 |
Validation of the CancerMath prognostic tool for breast cancer in Southeast Asia
H Miao, M Hartman, HM Verkooijen, NA Taib, HS Wong, S Subramaniam, CH Yip, EY Tan, P Chan, SC Lee, N Bhoo-Pathy |
BMC Cancer | 2016 |
Screening and characterization of novel specific peptides targeting MDA-MB-231 claudin-low breast carcinoma by computer-aided phage display methodologies
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BMC Cancer | 2016 |
Novel aromatase inhibitors selection using induced fit docking and extra precision methods: Potential clinical use in ER-alpha-positive breast cancer
R Kumavath, M Azad, P Devarapalli, S Tiwari, S Kar, D Barh, V Azevedo, AP Kumar |
Bioinformation | 2016 |
Inhibition of the autocrine IL-6–JAK2–STAT3–calprotectin axis as targeted therapy for HR − /HER2 + breast cancers
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Genes & development | 2015 |
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Oncogene | 2015 |
Triple Negative Breast Cancer: Nanosolutions for a Big Challenge
TF Mendes, LD Kluskens, LR Rodrigues |
Advanced Science | 2015 |
The Changing World of Breast Cancer: A Radiologistʼs Perspective
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Investigative Radiology | 2015 |
Prognostic and predictive values of long non-coding RNA LINC00472 in breast cancer
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Oncotarget | 2015 |
Prognostic value of receptor conversion after neoadjuvant chemotherapy in breast cancer patients: a prospective observational study
Jin X, Jiang YZ, Chen S, Yu KD, Shao ZM, Di GH |
Oncotarget | 2015 |
Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen ¿ urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression
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Breast Cancer Research | 2014 |
Regulation of mammary epithelial cell homeostasis by lncRNAs
AN Shore, JM Rosen |
The International Journal of Biochemistry & Cell Biology | 2014 |
Changing genetic paradigms: creating next-generation genetic databases as tools to understand the emerging complexities of genotype/phenotype relationships
B Gottlieb, LK Beitel, M Trifiro |
Human genomics | 2014 |
PARP inhibitor reduces proliferation and increases apoptosis in breast cancer cells
Y Shi, F Zhou, F Jiang, H Lu, J Wang, C Cheng |
Chinese Journal of Cancer Research | 2014 |
Evidence for the Existence of Triple-Negative Variants in the MCF-7 Breast Cancer Cell Population
E Leung, JE Kim, M Askarian-Amiri, GJ Finlay, BC Baguley |
BioMed Research International | 2014 |
Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression
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Scientific Reports | 2014 |
Illuminating breast cancer invasion: diverse roles for cell–cell interactions
KJ Cheung, AJ Ewald |
Current Opinion in Cell Biology | 2014 |
Chromosome-breakage genomic instability and chromothripsis in breast cancer
E Przybytkowski, E Lenkiewicz, MT Barrett, K Klein, S Nabavi, CM Greenwood, M Basik |
BMC Genomics | 2014 |
Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration
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Science signaling | 2014 |
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A Matsumoto, H Jinno, T Murata, T Seki, M Takahashi, T Hayashida, K Kameyama, Y Kitagawa |
International Journal of Clinical Oncology | 2014 |
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Huang O, Jiang M, Zhang X, Chen X, Wu J, Shen K |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 2014 |
Diffusion magnetic resonance imaging in breast cancer characterisation: correlations between the apparent diffusion coefficient and major prognostic factors.
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La radiologia medica | 2014 |
Peroxisome proliferator activated receptor-α/hypoxia inducible factor-1α interplay sustains carbonic anhydrase IX and apoliprotein E expression in breast cancer stem cells
A Papi, G Storci, T Guarnieri, SD Carolis, S Bertoni, N Avenia, A Sanguinetti, A Sidoni, D Santini, C Ceccarelli, M Taffurelli, M Orlandi, M Bonafé |
PloS one | 2013 |
In triple negative breast tumor cells, PLC-β2 promotes the conversion of CD133high to CD133low phenotype and reduces the CD133-related invasiveness
F Brugnoli, S Grassilli, M Piazzi, M Palomba, E Nika, A Bavelloni, S Capitani, V Bertagnolo |
Molecular Cancer | 2013 |
Systems biology of cancer: entropy, disorder, and selection-driven evolution to independence, invasion and "swarm intelligence"
M Tarabichi, A Antoniou, M Saiselet, JM Pita, G Andry, JE Dumont, V Detours, C Maenhaut |
Cancer metastasis reviews | 2013 |
Phenotypic Drift as a Cause for Intratumoral Morphological Heterogeneity of Invasive Ductal Breast Carcinoma Not Otherwise Specified
MV Zavyalova, EV Denisov, LA Tashireva, TS Gerashchenko, NV Litviakov, NA Skryabin, SV Vtorushin, NS Telegina, EM Slonimskaya, NV Cherdyntseva, VM Perelmuter |
BioResearch Open Access | 2013 |
STAT signaling in different breast cancer sub-types
PA Furth |
Molecular and Cellular Endocrinology | 2013 |
Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer
Q Peng, L Zhao, Y Hou, Y Sun, L Wang, H Luo, H Peng, M Liu |
PloS one | 2013 |
Repression of Zeb1 and Hypoxia Cause Sequential Mesenchymal-to-Epithelial Transition and Induction of Aid, Oct4, and Dnmt1, Leading to Immortalization and Multipotential Reprogramming of Fibroblasts in Spheres
Y Liu, P Mukhopadhyay, MM Pisano, X Lu, L Huang, Q Lu, DC Dean |
Stem Cells | 2013 |
No association between genetic variants in angiogenesis and inflammation pathway genes and breast cancer survival among Chinese women
T Dorjgochoo, Y Zheng, YT Gao, X Ma, J Long, P Bao, B Zhang, W Wen, W Lu, W Zheng, XO Shu, A Beeghly-Fadiel |
Cancer Epidemiology | 2013 |
Wnt signaling in triple negative breast cancer is associated with metastasis
N Dey, BG Barwick, CS Moreno, M Ordanic-Kodani, Z Chen, G Oprea-Ilies, W Tang, C Catzavelos, KF Kerstann, GW Sledge, M Abramovitz, M Bouzyk, P De, BR Leyland-Jones |
BMC Cancer | 2013 |
XRCC1 R399Q polymorphism and risk of normal tissue injury after radiotherapy in breast cancer patients
Y Zhou, W Zhou, Q Liu, Z Fan, Z Yang, Q Tu, L Li, H Liu |
Tumor Biology | 2013 |
The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
D Sisci, P Maris, MG Cesario, W Anselmo, R Coroniti, GE Trombino, F Romeo, A Ferraro, M Lanzino, S Aquila, M Maggiolini, L Mauro, C Morelli, S Andò |
Cell cycle (Georgetown, Tex.) | 2013 |
Transglutaminase 2 overexpression in tumor stroma identifies invasive ductal carcinomas of breast at high risk of recurrence
J Assi, G Srivastava, A Matta, MC Chang, PG Walfish, R Ralhan |
PloS one | 2013 |
Mass spectrometry imaging for in situ kinetic histochemistry
KB Louie, BP Bowen, S McAlhany, Y Huang, JC Price, J Mao, M Hellerstein, TR Northen |
Scientific Reports | 2013 |
Collective migration of cancer-associated fibroblasts is enhanced by overexpression of tight junction-associated proteins claudin-11 and occludin
GS Karagiannis, DF Schaeffer, CK Cho, N Musrap, P Saraon, I Batruch, A Grin, B Mitrovic, R Kirsch, RH Riddell, EP Diamandis |
Molecular Oncology | 2013 |
Characterising the tumour morphological response to therapeutic intervention: an ex vivo model
A Savage, E Katz, A Eberst, RE Falconer, A Houston, DJ Harrison, J Bown |
Disease models & mechanisms | 2013 |
Association between vitamin D receptor poly(A) polymorphism and breast cancer risk: a meta-analysis.
Xu J, Li H, Gu L, Zhou X |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine | 2013 |
Multiscale Models of Breast Cancer Progression
A Chakrabarti, S Verbridge, AD Stroock, C Fischbach, JD Varner |
Annals of Biomedical Engineering | 2012 |
Intra-tumour heterogeneity: a looking glass for cancer?
A Marusyk, V Almendro, K Polyak |
Nature Reviews Cancer | 2012 |
Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy: Figure 1
MA Swartz, N Iida, EW Roberts, S Sangaletti, MH Wong, FE Yull, LM Coussens, YA DeClerck |
Cancer research | 2012 |
PARP inhibition potentiates the cytotoxic activity of C-1305, a selective inhibitor of topoisomerase II, in human BRCA1-positive breast cancer cells
J Węsierska-Gądek, N Zulehner, F Ferk, A Składanowski, O Komina, M Maurer |
Biochemical Pharmacology | 2012 |
Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells
JW Ruan, YC Liao, I Lua, MH Li, CY Hsu, JH Chen |
Breast Cancer Research | 2012 |
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients
M Svoboda, J Sana, M Redova, J Navratil, M Palacova, P Fabian, O Slaby, R Vyzula |
Diagnostic Pathology | 2012 |
Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases
JC Hall, L Casciola-Rosen, AE Berger, EK Kapsogeorgou, C Cheadle, AG Tzioufas, AN Baer, A Rosen |
Proceedings of the National Academy of Sciences | 2012 |
Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo
L Waldmeier, N Meyer-Schaller, M Diepenbruck, G Christofori |
PloS one | 2012 |
Heterogeneity in breast cancer
Kornelia Polyak |
Journal of Clinical Investigation | 2011 |
MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b
G Roscigno, C Quintavalle, E Donnarumma, I Puoti, A Diaz-Lagares, M Iaboni, D Fiore, V Russo, M Todaro, G Romano, R Thomas, G Cortino, M Gaggianesi, M Esteller, CM Croce, G Condorelli |
Oncotarget | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |