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Abstract
The Fas ligand is predominantly expressed in activated T lymphocytes and is one of the major effector molecules of cytotoxic T lymphocytes and natural killer cells. Previously, we found excessive apoptosis of epithelial cells and infiltrating lymphocytes expressing Fas ligand mRNA in the lung tissue of bleomycin-induced pulmonary fibrosis in mice. Here we demonstrated that the administration of a soluble form of Fas antigen or anti-Fas ligand antibody prevented the development of this model and that lpr and gld mice were resistant against the induction of pneumopathy. These results suggest that the Fas-Fas ligand pathway plays an essential role in the development of pulmonary fibrosis and that preventing this pathway could have therapeutic value in lung injury and fibrosis.
Authors
Kazuyoshi Kuwano, Naoki Hagimoto, Masayuki Kawasaki, Takehiro Yatomi, Norio Nakamura, Shigekazu Nagata, Takashi Suda, Ritsuko Kunitake, Takashige Maeyama, Hiroyuki Miyazaki, Nobuyuki Hara
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Citations to this article (394)
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Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Apoptosis and the Airway Epithelium
SR White |
Journal of allergy | 2011 |
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Myofibroblast differentiation and survival in fibrotic disease
K Kis, X Liu, JS Hagood |
Expert Reviews in Molecular Medicine | 2011 |
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Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation
T Xie, J Liang, R Guo, N Liu, PW Noble, D Jiang |
Physiological genomics | 2011 |
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TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment
AL Degryse, H Tanjore, XC Xu, VV Polosukhin, BR Jones, CS Boomershine, C Ortiz, TP Sherrill, FB McMahon, LA Gleaves, TS Blackwell, WE Lawson |
AJP Lung Cellular and Molecular Physiology | 2011 |
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Redox-Based Regulation of Apoptosis: S-Glutathionylation as a Regulatory Mechanism to Control Cell Death
V Anathy, EC Roberson, AS Guala, KE Godburn, RC Budd, YM Janssen-Heininger |
Antioxidants & Redox Signaling | 2011 |
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The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis
G Pirzad, M Jafari, S Tavana, H Sadrayee, S Ghavami, A Shajiei, M Ghanei |
Journal of Toxicology | 2011 |
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The Role of Dimethylarginine Dimethylaminohydrolase in Idiopathic Pulmonary Fibrosis
SS Pullamsetti, R Savai, R Dumitrascu, BK Dahal, J Wilhelm, M Konigshoff, D Zakrzewicz, HA Ghofrani, N Weissmann, O Eickelberg, A Guenther, J Leiper, W Seeger, F Grimminger, RT Schermuly |
Science Translational Medicine | 2011 |
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Dual role of TGF-β1 on Fas-induced apoptosis in lung epithelial cells
L Bai, Z Yu, C Wang, G Qian, G Wang |
Respiratory Physiology & Neurobiology | 2011 |
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STY39, a Novel Alpha-Melanocyte-Stimulating Hormone Analogue, Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice
P Xu, Y Mao, H Meng, Y Tian, X Deng |
Shock | 2011 |
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Decoy receptor 3: A pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer
WW Lin, SL Hsieh |
Biochemical Pharmacology | 2011 |
|
Imaging in detecting sites of pulmonary fibrosis induced by paraquat
XL Xu, W Wang, ZJ Song, H Ding, XH Duan, HC Meng, J Chong |
World Journal of Emergency Medicine | 2011 |
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Apoptosis Modulation as a Promising Target for Treatment of Systemic Sclerosis
S Chabaud, VJ Moulin |
International Journal of Rheumatology | 2011 |
|
TGFβ signaling in lung epithelium regulates bleomycin-induced alveolar injury and fibroblast recruitment
AL Degryse, H Tanjore, XC Xu, VV Polosukhin, BR Jones, CS Boomershine, C Ortiz, TP Sherrill, FB McMahon, LA Gleaves, TS Blackwell, WE Lawson |
American journal of physiology. Lung cellular and molecular physiology | 2011 |
|
Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation
T Xie, J Liang, R Guo, N Liu, PW Noble, D Jiang |
Physiological genomics | 2011 |
|
Modern Concepts on the Role of Inflammation in Pulmonary Fibrosis
RJ Homer, JA Elias, CG Lee, E Herzog |
Archives of pathology & laboratory medicine | 2011 |
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Inhibition of Pulmonary Fibrosis by CXCL10 Requires Glycosaminoglycan Binding and Syndecan-4
Dianhua Jiang, Jiurong Liang, Gabriele Campanella, Rishu Guo, Shuang Yu, Ting Xie, Ningshan Liu, Yoosun Jung, Robert Homer, Eric B. Meltzer, Yuejuan Li, Andrew Tager, Paul Goetinck, Andrew D Luster, Paul W. Noble |
Journal of Clinical Investigation | 2010 |
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Modulation of lung inflammation by the Epstein-Barr virus protein Zta
JF Guenther, JE Cameron, HT Nguyen, Y Wang, DE Sullivan, B Shan, JA Lasky, EK Flemington, GF Morris |
AJP Lung Cellular and Molecular Physiology | 2010 |
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Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells
O Mungunsukh, AJ Griffin, YH Lee, RM Day |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
|
Apoptosis and Cell Death: Relevance to Lung
Saikumar P, Kar R |
2010 | |
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Regulation of apoptosis through cysteine oxidation: implications for fibrotic lung disease
YM Janssen-Heininger, SW Aesif, J der Velden, AS Guala, JN Reiss, EC Roberson, RC Budd, NL Reynaert, V Anathy |
Annals of the New York Academy of Sciences | 2010 |
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Inhibition of transforming growth factor-beta signalling attenuates interleukin (IL)-18 plus IL-2-induced interstitial lung disease in mice
S Segawa, D Goto, Y Yoshiga, M Sugihara, T Hayashi, Y Chino, I Matsumoto, S Ito, T Sumida |
Clinical & Experimental Immunology | 2010 |
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IPF: new insight on pathogenesis and treatment
S Harari, A Caminati |
Allergy | 2010 |
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Abnormal expression of telomerase/apoptosis limits type II alveolar epithelial cell replication in the early remodeling of usual interstitial pneumonia/idiopathic pulmonary fibrosis
DR Waisberg, JV Barbas-Filho, ER Parra, S Fernezlian, CR de Carvalho, RA Kairalla, VL Capelozzi |
Human Pathology | 2010 |
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Murray and Nadel's Textbook of Respiratory Medicine
MA Matthay, TR Martin |
Murray and Nadel's Textbook of Respiratory Medicine | 2010 |
|
Bleomycin induces the extrinsic apoptotic pathway in pulmonary endothelial cells
O Mungunsukh, AJ Griffin, YH Lee, RM Day |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
|
Modulation of lung inflammation by the Epstein-Barr virus protein Zta
JF Guenther, JE Cameron, HT Nguyen, Y Wang, DE Sullivan, B Shan, JA Lasky, EK Flemington, GF Morris |
American journal of physiology. Lung cellular and molecular physiology | 2010 |
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Production and Activation of Matrix Metalloproteinase 7 (Matrilysin 1) in the Lungs of Patients With Idiopathic Pulmonary Fibrosis
S Fujishima, T Shiomi, S Yamashita, Y Yogo, Y Nakano, T Inoue, M Nakamura, S Tasaka, N Hasegawa, N Aikawa, A Ishizaka, Y Okada |
Archives of pathology & laboratory medicine | 2010 |
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WISP1, a matricellular protein of the CCN family, is a novel mediator of pulmonary fibrosis
Melanie Königshoff, Monika Kramer, Nisha Balsara, Jochen Wilhelm, Oana Veronica Amarie, Andreas Jahn, Frank Rose, Ludger Fink, Werner Seeger, Liliana Schaefer, Andreas Günther, Oliver Eickelberg |
Journal of Clinical Investigation | 2009 |
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Mfge8 regulates tissue fibrosis by binding and targeting collagen for uptake by macrophages
Kamran Atabai, Sina Jame, Nabil Azhar, Alex Kuo, Michael Lam, William Mckleroy, Greg DeHart, Salman Rahman, Dee Dee Xia, Andrew Melton, Claire Emson, Scott Turner, Paul Wolters, Zena Werb, Dean Sheppard |
Journal of Clinical Investigation | 2009 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Pulmonary fibrosis: pathogenesis, etiology and regulation
MS Wilson, TA Wynn |
Mucosal Immunology | 2009 |
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Possible mechanisms of kidney repair
P Romagnani, R Kalluri |
Fibrogenesis & Tissue Repair | 2009 |
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Systemic Inhibition of NF-κB Activation Protects from Silicosis
MD Giuseppe, F Gambelli, GW Hoyle, G Lungarella, SM Studer, T Richards, S Yousem, K McCurry, J Dauber, N Kaminski, G Leikauf, LA Ortiz, PJ Barnes |
PloS one | 2009 |
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Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis
SI Cha, SD Groshong, SK Frankel, BL Edelman, GP Cosgrove, JL Terry-Powers, LK Remigio, D Curran-Everett, KK Brown, CD Cool, DW Riches |
American journal of respiratory cell and molecular biology | 2009 |
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Is the Fas/Fas-L Pathway a Promising Target for Treating Inflammatory Heart Disease?
A Henriques-Pons, GM de Oliveira |
Journal of Cardiovascular Pharmacology | 2009 |
|
Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses
TY Chen, KH Chi, JS Wang, CL Chien, WW Lin |
Free radical biology & medicine | 2009 |
|
A Six-Nucleotide Insertion-Deletion Polymorphism in theCASP8Promoter is Associated with Risk of Coal Workers' Pneumoconiosis
C Ni, Y Ye, M Wang, H Qian, Z Song, X Jia, J Zhou |
Journal of Toxicology and Environmental Health, Part A | 2009 |
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Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice
T Hoshino, M Okamoto, Y Sakazaki, S Kato, HA Young, H Aizawa |
American journal of respiratory cell and molecular biology | 2009 |
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EFFECTS OF ELASTASE INHIBITOR ON THE EPITHELIAL CELL APOPTOSIS IN BLEOMYCIN-INDUCED PULMONARY FIBROSIS
JS Song, CM Kang, CK Rhee, HK Yoon, YK Kim, HS Moon, SH Park |
Experimental Lung Research | 2009 |
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Amphiregulin attenuates bleomycin-induced pneumopathy in mice
J Fukumoto, C Harada, T Kawaguchi, S Suetsugu, T Maeyama, I Inoshima, N Hamada, K Kuwano, Y Nakanishi |
American journal of physiology. Lung cellular and molecular physiology | 2009 |
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Differential Role of the Fas/Fas Ligand Apoptotic Pathway in Inflammation and Lung Fibrosis Associated with Reovirus 1/L-Induced Bronchiolitis Obliterans Organizing Pneumonia and Acute Respiratory Distress Syndrome
AD Lopez, S Avasarala, S Grewal, AK Murali, L London |
Journal of immunology (Baltimore, Md. : 1950) | 2009 |
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Essentials of Apoptosis
Z Dong, XM Yin |
2009 | |
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Involvement of C-jun NH 2 -terminal kinase and apoptosis induced factor in apoptosis induced by deglycosylated bleomycin in laryngeal carcinoma cells
S Brahim, S Aroui, K Abid, A Kenani |
Cell Biology International | 2009 |
|
CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model
K Komura, K Yanaba, M Horikawa, F Ogawa, M Fujimoto, TF Tedder, S Sato |
Arthritis & Rheumatism | 2008 |
|
Fibrogenesis of parenchymal organs
T Kisseleva, DA Brenner |
Proceedings of the American Thoracic Society | 2008 |
|
Escape from the matrix: multiple mechanisms for fibroblast activation in pulmonary fibrosis
GJ Laurent, RJ McAnulty, M Hill, R Chambers |
Proceedings of the American Thoracic Society | 2008 |
|
Involvement of Epithelial Cell Apoptosis in Interstitial Lung Diseases
K Kuwano |
Internal Medicine | 2008 |
|
Morphological and molecular markers in idiopathic pulmonary fibrosis
F Calabrese, C Giacometti, F Lunardi, M Valente |
Expert Review of Respiratory Medicine | 2008 |
|
The Immunobiology of Systemic Sclerosis
YS Gu, J Kong, GS Cheema, CL Keen, G Wick, ME Gershwin |
Seminars in Arthritis and Rheumatism | 2008 |
|
TGF-β1 as a therapeutic target for pulmonary fibrosis and COPD
HR Kang, JY Lee, CG Lee |
Expert Review of Clinical Pharmacology | 2008 |
|
Stress in the ER (endoplasmic reticulum): a matter of life and death for epithelial cells
JC Horowitz, AH Limper |
American journal of respiratory and critical care medicine | 2008 |
|
Dimeric Galectin-8 induces phosphatidylserine exposure in leukocytes through polylactosamine recognition by the C-terminal domain
SR Stowell, CM Arthur, KA Slanina, JR Horton, DF Smith, RD Cummings |
The Journal of biological chemistry | 2008 |
|
Apoptosis, airway inflammation and anti-asthma therapy: From immunobiology to clinical application
F Spinozzi, D Benedictis, FM Benedictis |
Pediatric Allergy and Immunology | 2008 |
|
Epithelial cell fate following lung injury
K Kuwano, J Araya, K Nakayama |
Expert Review of Respiratory Medicine | 2008 |
|
Recombinant human erythropoietin reduces epithelial cell apoptosis and attenuates bleomycin-induced pneumonitis in mice
M YOSHIMI, T MAEYAMA, M YAMADA, N HAMADA, J FUKUMOTO, T KAWAGUCHI, K KUWANO, Y NAKANISHI |
Respirology | 2008 |
|
The Role of High Mobility Group Box1 in Pulmonary Fibrosis
N Hamada, T Maeyama, T Kawaguchi, M Yoshimi, J Fukumoto, M Yamada, S Yamada, K Kuwano, Y Nakanishi |
American journal of respiratory cell and molecular biology | 2008 |
|
The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation1
L Wang, N Azad, L Kongkaneramit, F Chen, Y Lu, BH Jiang, Y Rojanasakul |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
PULMONARY AND SYSTEMIC TOXICITY OF BLEOMYCIN ON SEVERE COMBINED IMMUNE DEFICIENCY MICE
H Miyazawa, Y Takiguchi, K Hiroshima, K Kurosu, Y Tada, Y Kasahara, S Sakao, N Tanabe, K Tatsumi, T Kuriyama |
Experimental Lung Research | 2008 |
|
Dimeric Galectin-8 Induces Phosphatidylserine Exposure in Leukocytes through Polylactosamine Recognition by the C-terminal Domain
SR Stowell, CM Arthur, KA Slanina, JR Horton, DF Smith, RD Cummings |
The Journal of biological chemistry | 2008 |
|
Mechanisms of Fibrogenesis
T Kisseleva, DA Brenner |
Experimental biology and medicine (Maywood, N.J.) | 2008 |
|
Transforming Growth Factor-β in Cancer Therapy, Volume I
SB Jakowlew |
2008 | |
|
Molecular Pathology of Lung Diseases
DS Zander, HH Popper, J Jagirdar, AK Haque, PT Cagle, R Barrios |
2008 | |
|
The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation
L Wang, N Azad, L Kongkaneramit, F Chen, Y Lu, BH Jiang, Y Rojanasakul |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |
|
Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury
LA Ortiz, M Dutreil, C Fattman, AC Pandey, G Torres, K Go, DG Phinney |
Proceedings of the National Academy of Sciences | 2007 |
|
THE FAS/FAS-LIGAND PATHWAY DOES NOT MEDIATE THE APOPTOSIS IN ELASTASE-INDUCED EMPHYSEMA IN MICE
M Sawada, Y Ohno, BL La, N Funaguchi, T Asai, H Yuhgetsu, G Takemura, S Minatoguchi, H Fujiwara, T Fujiwara |
Experimental Lung Research | 2007 |
|
P21 regulates TGF-beta1-induced pulmonary responses via a TNF-alpha-signaling pathway
M Yamasaki, HR Kang, RJ Homer, SP Chapoval, SJ Cho, BJ Lee, JA Elias, CG Lee |
American journal of respiratory cell and molecular biology | 2007 |
|
Susceptibility of Hermansky-Pudlak mice to bleomycin-induced type II cell apoptosis and fibrosis
LR Young, R Pasula, PM Gulleman, GH Deutsch, FX McCormack |
American journal of respiratory cell and molecular biology | 2007 |
|
Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production
N Matsumoto, R Imamura, T Suda |
FEBS Journal | 2007 |
|
Fas ligand-dependent inflammatory regulation in acute myocarditis induced by Trypanosoma cruzi infection
GM de Oliveira, RL Diniz, W Batista, MM Batista, CB Correa, TC de Araújo-Jorge, A Henriques-Pons |
The American Journal of Pathology | 2007 |
|
THE SPECIFIC FREE RADICAL SCAVENGER EDARAVONE SUPPRESSES BLEOMYCIN-INDUCED ACUTE PULMONARY INJURY IN RABBITS
T Asai, Y Ohno, S Minatoguchi, N Funaguchi, H Yuhgetsu, M Sawada, G Takemura, A Komada, T Fujiwara, H Fujiwara |
Clinical and Experimental Pharmacology and Physiology | 2007 |
|
Anti-fibrotic effect of meloxicam in a murine lung fibrosis model
HM Arafa, MH Abdel-Wahab, MF El-Shafeey, OA Badary, FM Hamada |
European Journal of Pharmacology | 2007 |
|
Vascular endothelial growth factor promotes physical wound repair and is anti-apoptotic in primary distal lung epithelial and A549 cells:
JR Roberts, GD Perkins, T Fujisawa, KA Pettigrew, F Gao, A Ahmed, DR Thickett |
Critical Care Medicine | 2007 |
|
Deglycosylated bleomycin induces apoptosis in lymphoma cell via c-jun NH2-terminal kinase but not reactive oxygen species
B Souhir, P Laurent, Y Sonia, M Delphine, C Marion, R Cédric, M Olivier, K Abderraouf, B Ali |
Biochemical Pharmacology | 2007 |
|
Intoxication pulmonaire fatale à la bléomycine
K Znati, N Cherradi, N Lamaalmi, A Mikou, S Ec-Charif, A Malihy, ZA Hamany |
Antibiotiques | 2007 |
|
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
E Abraham, M Singer |
2007 | |
|
E- and P-Selectins Synergistically Inhibit Bleomycin-Induced Pulmonary Fibrosis
M Horikawa, M Fujimoto, M Hasegawa, T Matsushita, Y Hamaguchi, A Kawasuji, Y Matsushita, T Fujita, F Ogawa, K Takehara, DA Steeber, S Sato |
The American Journal of Pathology | 2006 |
|
Soluble TNF mediates the transition from pulmonary inflammation to fibrosis
N Oikonomou, V Harokopos, J Zalevsky, C Valavanis, A Kotanidou, DE Szymkowski, G Kollias, V Aidinis |
PloS one | 2006 |
|
Epithelial-mesenchymal interactions in pulmonary fibrosis
JC Horowitz, VJ Thannickal |
Seminars in respiratory and critical care medicine | 2006 |
|
Microarray identifies ADAM family members as key responders to TGF-β1 in alveolar epithelial cells
DT Keating, DM Sadlier, A Patricelli, SM Smith, D Walls, JJ Egan, PP Doran |
Respiratory Research | 2006 |
|
Proapoptotic Bid is required for pulmonary fibrosis
GR Budinger, GM Mutlu, J Eisenbart, AC Fuller, AA Bellmeyer, CM Baker, M Wilson, K Ridge, TA Barrett, VY Lee, NS Chandel |
Proceedings of the National Academy of Sciences | 2006 |
|
The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?
T Yamamoto |
Archives of Dermatological Research | 2006 |
|
Idiopathic Pulmonary Fibrosis
JC Horowitz, VJ Thannickal |
Treatments in Respiratory Medicine | 2006 |
|
Idiopathic pulmonary fibrosis : new concepts in pathogenesis and implications for drug therapy
JC Horowitz, VJ Thannickal |
Treatments in Respiratory Medicine | 2006 |
|
Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte–dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18
IG Luzina, JC Papadimitriou, R Anderson, K Pochetuhen, SP Atamas |
Arthritis & Rheumatism | 2006 |
|
Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma
T Yamamoto, H Yokozeki, K Nishioka |
Archives of Dermatological Research | 2006 |
|
Hypoxia-targeted bioreductive tyrosine kinase inhibitors with glutathione-depleting function
R Sarangarajan, SP Apte, SO Ugwu |
Anti-Cancer Drugs | 2006 |
|
Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
L Wang, JF Scabilloni, JM Antonini, V Castranova, Y Rojanasakul, JR Roberts, Z Zhang, RR Mercer |
Laboratory Investigation | 2006 |
|
Irradiation-Induced Pneumonitis Mediated by the CD95/CD95-Ligand System
F Heinzelmann, V Jendrossek, K Lauber, K Nowak, T Eldh, R Boras, R Handrick, M Henkel, C Martin, S Uhlig, D Kohler, HK Eltzschig, M Wehrmann, W Budach, C Belka |
JNCI Journal of the National Cancer Institute | 2006 |
|
Idiopathic Pulmonary Fibrosis: New Concepts in Pathogenesis and Implications for Drug Therapy
JC Horowitz, VJ Thannickal |
Treatments in Respiratory Medicine | 2006 |
|
Alterations of Fas and Fas-related molecules in patients with silicosis
T Otsuki, Y Miura, Y Nishimura, F Hyodoh, A Takata, M Kusaka, H Katsuyama, M Tomita, A Ueki, T Kishimoto |
Experimental biology and medicine (Maywood, N.J.) | 2006 |
|
Particle Toxicology
D Brown, G Hutchison, V Stone, P Barlow |
Particle Toxicology | 2006 |
|
Sequential Gene Expression Profiling in Lung Transplant Recipients With Chronic Rejection
BS Lu, AD Yu, X Zhu, ER Garrity, WT Vigneswaran, SM Bhorade |
Chest | 2006 |
|
Bleomycin initiates apoptosis of lung epithelial cells by ROS but not by Fas/FasL pathway
SB Wallach-Dayan, G Izbicki, PY Cohen, R Gerstl-Golan, A Fine, R Breuer |
American journal of physiology. Lung cellular and molecular physiology | 2006 |
|
Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats
L Wang, JF Scabilloni, JM Antonini, Y Rojanasakul, V Castranova, RR Mercer |
American journal of physiology. Lung cellular and molecular physiology | 2006 |
|
Principles of Molecular Medicine
MS Runge, C Patterson |
2006 | |
|
Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells
SR Stowell, S Karmakar, CJ Stowell, M Dias-Baruffi, RP McEver, RD Cummings |
Blood | 2006 |
|
Gene Therapy for Lung Diseases
Alton EW, Davies JC, Geddes DM |
2006 | |
|
Expression of apoptotic and antiapoptotic markers in epithelial cells in idiopathic pulmonary fibrosis
M Plataki, AV Koutsopoulos, K Darivianaki, G Delides, NM Siafakas, D Bouros |
Chest | 2005 |
|
Natural killer T (NKT) cells attenuate bleomycin-induced pulmonary fibrosis by producing interferon-gamma
JH Kim, HY Kim, S Kim, JH Chung, WS Park, DH Chung |
The American Journal of Pathology | 2005 |
|
TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis
SK Frankel, GP Cosgrove, SI Cha, CD Cool, MW Wynes, BL Edelman, KK Brown, DW Riches |
American journal of respiratory cell and molecular biology | 2005 |
|
Modulation of Prosurvival Signaling in Fibroblasts by a Protein Kinase Inhibitor Protects against Fibrotic Tissue Injury
R Vittal, JC Horowitz, BB Moore, H Zhang, FJ Martinez, GB Toews, TJ Standiford, VJ Thannickal |
The American Journal of Pathology | 2005 |
|
Regulation of lung injury and repair by Toll-like receptors and hyaluronan
D Jiang, J Liang, J Fan, S Yu, S Chen, Y Luo, GD Prestwich, MM Mascarenhas, HG Garg, DA Quinn, RJ Homer, DR Goldstein, R Bucala, PJ Lee, R Medzhitov, PW Noble |
Nature Medicine | 2005 |
|
Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis
M Watanabe, M Ebina, FM Orson, A Nakamura, K Kubota, D Koinuma, K Akiyama, M Maemondo, S Okouchi, M Tahara, K Matsumoto, T Nakamura, T Nukiwa |
Molecular Therapy | 2005 |
|
Role of vascular cell adhesion molecules and leukocyte apoptosis in the lymphopenia and thrombocytopenia of patients with severe acute respiratory syndrome (SARS)
RF Chen, JC Chang, WT Yeh, CH Lee, JW Liu, HL Eng, KD Yang |
Microbes and infection / Institut Pasteur | 2005 |
|
Apoptosis and epithelial injury in the lungs
TR Martin, N Hagimoto, M Nakamura, G Matute-Bello |
Proceedings of the American Thoracic Society | 2005 |
|
Anti-Vascular Endothelial Growth Factor Gene Therapy Attenuates Lung Injury and Fibrosis in Mice
N Hamada, K Kuwano, M Yamada, N Hagimoto, K Hiasa, K Egashira, N Nakashima, T Maeyama, M Yoshimi, Y Nakanishi |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
|
Relationship of Acute Lung Inflammatory Injury to Fas/FasL System
TA Neff, RF Guo, SB Neff, JV Sarma, CL Speyer, H Gao, KD Bernacki, M Huber-Lang, S McGuire, LM Hoesel, NC Riedemann, B Beck-Schimmer, FS Zetoune, PA Ward |
The American Journal of Pathology | 2005 |
|
Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective
T Yamamoto, K Nishioka |
Experimental Dermatology | 2005 |
|
Increased and prolonged pulmonary fibrosis in surfactant protein C-deficient mice following intratracheal bleomycin
WE Lawson, VV Polosukhin, GT Stathopoulos, O Zoia, W Han, KB Lane, B Li, EF Donnelly, GE Holburn, KG Lewis, RD Collins, WM Hull, SW Glasser, JA Whitsett, TS Blackwell |
The American Journal of Pathology | 2005 |
|
Apoptosis and release of CD44s in bleomycin-treated L132 cells
R Koslowski, F Fichtner, K Barth, C Roehlecke, D Seidel, M Kasper |
Journal of Cellular Biochemistry | 2005 |
|
Fas/FasL interaction: A novel immune therapy approach with immobilized biologicals
M Scholz, J Cinatl |
Medicinal Research Reviews | 2005 |
|
Tacrolimus (FK506) has protective actions against murine bleomycin-induced acute lung injuries
T Koshika, Y Hirayama, Y Ohkubo, S Mutoh, A Ishizaka |
European Journal of Pharmacology | 2005 |
|
Mécanismes de la fibrogenèse pulmonaire
P Bonniaud |
Revue des Maladies Respiratoires | 2005 |
|
Side Effects and Good Effects from New Chemotherapeutic Agents: CASE 1. Gefitinib-Induced Interstitial Fibrosis
NC Nagaria, J Cogswell, JK Choe, B Kasimis |
Journal of Clinical Oncology | 2005 |
|
Bleomycin induces alveolar epithelial cell death through JNK-dependent activation of the mitochondrial death pathway
VY Lee, C Schroedl, JK Brunelle, LJ Buccellato, OI Akinci, H Kaneto, C Snyder, J Eisenbart, GR Budinger, NS Chandel |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
|
Keratinocyte growth factor induces Akt kinase activity and inhibits Fas-mediated apoptosis in A549 lung epithelial cells
S Bao, Y Wang, P Sweeney, A Chaudhuri, AI Doseff, CB Marsh, DL Knoell |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
|
Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts
GS Bogatkevich, E Gustilo, JC Oates, C Feghali-Bostwick, RA Harley, RM Silver, A Ludwicka-Bradley |
American journal of physiology. Lung cellular and molecular physiology | 2005 |
|
Fas Ligand Induces Cell-Autonomous IL-23 Production in Dendritic Cells, a Mechanism for Fas Ligand-Induced IL-17 Production
H Kidoya, M Umemura, T Kawabe, G Matsuzaki, A Yahagi, R Imamura, T Suda |
Journal of immunology (Baltimore, Md. : 1950) | 2005 |
|
Skeletal muscle targeting in vivo electroporation-mediated HGF gene therapy of bleomycin-induced pulmonary fibrosis in mice
Y Umeda, T Marui, Y Matsuno, K Shirahashi, H Iwata, H Takagi, K Matsumoto, T Nakamura, A Kosugi, Y Mori, H Takemura |
Laboratory Investigation | 2004 |
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Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β 1 –induced Pulmonary Fibrosis
CG Lee, SJ Cho, MJ Kang, SP Chapoval, PJ Lee, PW Noble, T Yehualaeshet, B Lu, RA Flavell, J Milbrandt, RJ Homer, JA Elias |
Journal of Experimental Medicine | 2004 |
|
The central role of Fas-ligand cell signaling in inflammatory lung diseases
GA DosReis, VM Borges, WA Zin |
Journal of Cellular and Molecular Medicine | 2004 |
|
Mechanisms of Pulmonary Fibrosis
VJ Thannickal, GB Toews, ES White, JP Lynch, FJ Martinez |
Annual Review of Medicine | 2004 |
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Understanding the mechanisms of drug-associated interstitial lung disease
T Higenbottam, K Kuwano, B Nemery, Y Fujita |
British Journal of Cancer | 2004 |
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Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses
T Takehara, T Tatsumi, T Suzuki, EB Rucker, L Hennighausen, M Jinushi, T Miyagi, Y Kanazawa, N Hayashi |
Gastroenterology | 2004 |
|
Functional dichotomy: glutathione and vitamin E in homeostasis relevant to primary open-angle glaucoma
J Veach |
British Journal of Nutrition | 2004 |
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The perforin mediated apoptotic pathway in lung injury and fibrosis
H Miyazaki, K Kuwano, K Yoshida, T Maeyama, M Yoshimi, M Fujita, N Hagimoto, R Yoshida, Y Nakanishi |
Journal of clinical pathology | 2004 |
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Idiopathic pulmonary fibrosis: new insights into pathogenesis
PW Noble, RJ Homer |
Clinics in Chest Medicine | 2004 |
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Long-term Clinical Follow-up, without Antiretroviral Therapy, of Patients with Chronic HIV-1 Infection with Good Virological Response to Structured Treatment Interruption
E Florence, F Garcia, M Plana, E Fumero, P Castro, A Lopez, A Cruceta, C Gil, M Arnedo, JM Miro, T Pumarola, T Gallart, JM Gatell |
Clinical Infectious Diseases | 2004 |
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Possible Role of Apoptosis in the Pathogenesis of Bleomycin-Induced Scleroderma
T Yamamoto, K Nishioka |
Journal of Investigative Dermatology | 2004 |
|
The influence of dexamethasone on the proliferation and apoptosis of pulmonary inflammatory cells in bleomycin-induced pulmonary fibrosis in rats
H Li, X Li, G He, X Yi, AP Kaplan |
Respirology | 2004 |
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Mechanisms in pulmonary toxicology
LM Delaunois |
Clinics in Chest Medicine | 2004 |
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Evaluation of the apoptogenic potential of hard metal dust (WC–Co), tungsten carbide and metallic cobalt
N Lombaert, MD Boeck, I Decordier, E Cundari, D Lison, M Kirsch-Volders |
Toxicology Letters | 2004 |
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Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice
I Inoshima, K Kuwano, N Hamada, N Hagimoto, M Yoshimi, T Maeyama, A Takeshita, S Kitamoto, K Egashira, N Hara |
American journal of physiology. Lung cellular and molecular physiology | 2004 |
|
Induction of CDK inhibitor p21 gene as a new therapeutic strategy against pulmonary fibrosis
I Inoshima, K Kuwano, N Hamada, M Yoshimi, T Maeyama, N Hagimoto, Y Nakanishi, N Hara |
American journal of physiology. Lung cellular and molecular physiology | 2004 |
|
Balance of proliferation and cell death between thyrocytes and myofibroblasts regulates thyroid fibrosis in granulomatous experimental autoimmune thyroiditis (G-EAT)
K Chen, Y Wei, GC Sharp, H Braley-Mullen |
Journal of leukocyte biology | 2004 |
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Increased level of soluble E-selectin in the serum from patients with idiopathic pulmonary fibrosis
S Hayashi, K Abe, H Matsuoka, S Goya, H Morishita, M Mori, T Arai, H Kida, K Nishino, Y Takeda, T Osaki, I Tachibana, K Kimura, S Yokota, Y Inoue, M Sakatani |
Inflammation | 2004 |
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The mechanisms of idiopathic pulmonary fibrosis: can we see the elephant?
K Gibson, N Kaminski |
Drug Discovery Today: Disease Mechanisms | 2004 |
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Inhibitors of Poly(ADP-Ribose) Polymerase Modulate Signal Transduction Pathways and the Development of Bleomycin-Induced Lung Injury
T Genovese |
The Journal of pharmacology and experimental therapeutics | 2004 |
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Differential Response of Human Lung Epithelial Cells to Fas-Induced Apoptosis
M Nakamura, G Matute-Bello, WC Liles, S Hayashi, O Kajikawa, SM Lin, CW Frevert, TR Martin |
The American Journal of Pathology | 2004 |
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T Cell–specific Ablation of Fas Leads to Fas Ligand–mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis
Z Hao, B Hampel, H Yagita, K Rajewsky |
Journal of Experimental Medicine | 2004 |
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Involvement of IL-17 in Fas ligand-induced inflammation
M Umemura, T Kawabe, K Shudo, H Kidoya, M Fukui, M Asano, Y Iwakura, G Matsuzaki, R Imamura, T Suda |
International Immunology | 2004 |
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Fas Ligand Induces Cell-autonomous NF-κB Activation and Interleukin-8 Production by a Mechanism Distinct from That of Tumor Necrosis Factor-α
R Imamura, K Konaka, N Matsumoto, M Hasegawa, M Fukui, N Mukaida, T Kinoshita, T Suda |
The Journal of biological chemistry | 2004 |
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Apoptosis in lung injury and remodeling
X Li, R Shu, G Filippatos, BD Uhal |
Journal of applied physiology | 2004 |
|
Role of IFN-γ and IL-2 in rat lung epithelial cell migration and apoptosis after oxidant injury
O Lesur, M Brisebois, A Thibodeau, F Chagnon, D Lane, T Füllöp |
American journal of physiology. Lung cellular and molecular physiology | 2004 |
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Perioperative and Critical Care Medicine
A Gullo, G Berlot, U Lucangelo, T Pellis |
2004 | |
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Differential response of human lung epithelial cells to fas-induced apoptosis.
Nakamura M, Matute-Bello G, Liles WC, Hayashi S, Kajikawa O, Lin SM, Frevert CW, Martin TR |
The American Journal of Pathology | 2004 |
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Science review: apoptosis in acute lung injury
G Matute-Bello, TR Martin |
Critical Care | 2003 |
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The role of apoptosis in acute lung injury
TR Martin, M Nakamura, G Matute-Bello |
Critical Care Medicine | 2003 |
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Alveolar macrophages from subjects with chronic obstructive pulmonary disease are deficient in their ability to phagocytose apoptotic airway epithelial cells
S Hodge, G Hodge, R Scicchitano, PN Reynolds, M Holmes |
Immunology and Cell Biology | 2003 |
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Bleomycin-induced pulmonary toxicity in chemotherapy for testicular cancer
K Kawai, H Akaza |
Expert Opinion on Drug Safety | 2003 |
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Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction
M Moss, EL Burnham |
Critical Care Medicine | 2003 |
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Epithelial apoptosis in experimental obliterative airway disease after lung transplantation
HS Alho, US Salminen, PK Maasilta, P Pääkkö, AL Harjula |
The Journal of Heart and Lung Transplantation | 2003 |
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Role of Fas/Fas ligand-mediated apoptosis in murine contact hypersensitivity
B Xu, S Bulfone-Paus, K Aoyama, S Yu, P Huang, K Morimoto, T Matsushita, T Takeuchi |
International Immunopharmacology | 2003 |
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Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients
IG Luzina, SP Atamas, R Wise, FM Wigley, J Choi, HQ Xiao, B White |
Arthritis & Rheumatism | 2003 |
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Drugs and the Pharmaceutical Sciences
D Thompson |
Drugs and the Pharmaceutical Sciences | 2003 |
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Lung Biology in Health and Disease
N Zamel |
Lung Biology in Health and Disease: Experimental Models and Therapeutic Potential | 2003 |
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Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization, and recognition of phosphatidylserine
VE Kagan, GG Borisenko, BF Serinkan, YY Tyurina, VA Tyurin, J Jiang, SX Liu, AA Shvedova, JP Fabisiak, W Uthaisang, B Fadeel |
American journal of physiology. Lung cellular and molecular physiology | 2003 |
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Repression of Bleomycin-Induced Pneumopathy by TNF
M Kuroki, Y Noguchi, M Shimono, K Tomono, T Tashiro, Y Obata, E Nakayama, S Kohno |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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Acceleration of Human Neutrophil Apoptosis by TRAIL
SA Renshaw, JS Parmar, V Singleton, SJ Rowe, DH Dockrell, SK Dower, CD Bingle, ER Chilvers, MK Whyte |
Journal of immunology (Baltimore, Md. : 1950) | 2003 |
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TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells
N Hagimoto, K Kuwano, I Inoshima, M Yoshimi, N Nakamura, M Fujita, T Maeyama, N Hara |
Journal of immunology (Baltimore, Md. : 1950) | 2002 |
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Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans
F Zuo, N Kaminski, E Eugui, J Allard, Z Yakhini, A Ben-Dor, L Lollini, D Morris, Y Kim, B DeLustro, D Sheppard, A Pardo, M Selman, RA Heller |
Proceedings of the National Academy of Sciences | 2002 |
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Adenovirus-Mediated Transfer and Overexpression of Heme Oxygenase 1 cDNA in Lung Prevents Bleomycin-Induced Pulmonary Fibrosis via a Fas–Fas Ligand-Independent Pathway
T Tsuburai, M Suzuki, Y Nagashima, S Suzuki, S Inoue, T Hashiba, A Ueda, K Ikehara, T Matsuse, Y Ishigatsubo |
Human Gene Therapy | 2002 |
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Activation of the Fas/Fas ligand pathway in hypertensive renal disease in Dahl/Rapp rats
PW Sanders, PX Wang |
BMC Nephrology | 2002 |
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Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
KH Albertine, MF Soulier, Z Wang, A Ishizaka, S Hashimoto, GA Zimmerman, MA Matthay, LB Ware |
The American Journal of Pathology | 2002 |
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Fas-Ligand—Iron Fist or Achilles' Heel?
AM Hohlbaum, RR Saff, A Marshak-Rothstein |
Clinical Immunology | 2002 |
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Increased circulating levels of soluble Fas ligand are correlated with disease activity in patients with fibrosing lung diseases
K Kuwano, T Maeyama, I Inoshima, K Ninomiya, N Hagimoto, M Yoshimi, M Fujita, N Nakamura, K Shirakawa, N Hara |
Respirology | 2002 |
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POTENTIATION OF FAS- AND TRAIL-MEDIATED APOPTOSIS BY IFN-γ IN A549 LUNG EPITHELIAL CELLS: ENHANCEMENT OF CASPASE-8 EXPRESSION THROUGH IFN-RESPONSE ELEMENT
KB Kim, YH Choi, IK Kim, CW Chung, BJ Kim, YM Park, YK Jung |
Cytokine | 2002 |
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Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells
CR Timblin, A Shukla, I Berlanger, KA BeruBe, A Churg, BT Mossman |
Toxicology and Applied Pharmacology | 2002 |
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Hydrogen Peroxide Induces Upregulation of Fas in Human Airway Epithelial Cells via the Activation of PARP-p53 Pathway
T Fujita, M Maruyama, J Araya, K Sassa, Y Kawagishi, R Hayashi, S Matsui, T Kashii, N Yamashita, E Sugiyama, M Kobayashi |
American journal of respiratory cell and molecular biology | 2002 |
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Matrilysin Shedding of Syndecan-1 Regulates Chemokine Mobilization and Transepithelial Efflux of Neutrophils in Acute Lung Injury
Q Li, PW Park, CL Wilson, WC Parks |
Cell | 2002 |
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Apoptosis in Lung Fibrosis and Repair*
BD Uhal |
Chest | 2002 |
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A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis
H Matsuoka, T Arai, M Mori, S Goya, H Kida, H Morishita, H Fujiwara, I Tachibana, T Osaki, S Hayashi |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
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Inhibition of proteasome activity is involved in cobalt-induced apoptosis of human alveolar macrophages
J Araya, M Maruyama, A Inoue, T Fujita, J Kawahara, K Sassa, R Hayashi, Y Kawagishi, N Yamashita, E Sugiyama, M Kobayashi |
American journal of physiology. Lung cellular and molecular physiology | 2002 |
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Yearbook of Intensive Care and Emergency Medicine 2002
JL Vincent |
2002 | |
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The importance of balanced pro-inflammatory and anti-inflammatory mechanisms in diffuse lung disease
MP Keane, RM Strieter |
Respiratory Research | 2001 |
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Effect of Chronic Ethanol Ingestion on Alveolar Type II Cell: Glutathione and Inflammatory Mediator-Induced Apoptosis
LA Brown, FL Harris, R Bechara, DM Guidot |
Alcoholism, clinical and experimental research | 2001 |
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Fas (CD95) Induces Alveolar Epithelial Cell Apoptosis in Vivo
G Matute-Bello, RK Winn, M Jonas, EY Chi, TR Martin, WC Liles |
The American Journal of Pathology | 2001 |
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Growth factors in idiopathic pulmonary fibrosis: relative roles
JT Allen, MA Spiteri |
Respiratory Research | 2001 |
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Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo
T Hisatomi, T Sakamoto, T Murata, I Yamanaka, Y Oshima, Y Hata, T Ishibashi, H Inomata, SA Susin, G Kroemer |
The American Journal of Pathology | 2001 |
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Fas-mediated hepatocyte apoptosis is increased by hepatitis C virus infection and alcohol consumption, and may be associated with hepatic fibrosis: mechanisms of liver cell injury in chronic hepatitis C virus infection
S Pianko, S Patella, G Ostapowicz, P Desmond, W Sievert |
Journal of Viral Hepatitis | 2001 |
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Apoptosis and JNK activation are differentially regulated by Fas expression level in renal tubular epithelial cells
S Khan, A Koepke, G Jarad, K Schlessman, RP Cleveland, B Wang, M Konieczkowski, JR Schelling |
Kidney International | 2001 |
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Immunological capabilities of skeletal muscle cells
K Nagaraju |
Acta Physiologica Scandinavica | 2001 |
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Inflammation
JA Hunt |
Encyclopedia of Materials Science and Technology | 2001 |
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Hypersensitivity pneumonitis: Current concepts and future questions
AM Patel, JH Ryu, CE Reed |
Journal of Allergy and Clinical Immunology | 2001 |
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Attenuation of bleomycin-induced pneumopathy in mice by monoclonal antibody to interleukin-12
T Maeyama, K Kuwano, M Kawasaki, R Kunitake, N Hagimoto, N Hara |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
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Recombinant human Fas ligand induces alveolar epithelial cell apoptosis and lung injury in rabbits
G Matute-Bello, WC Liles, CW Frevert, M Nakamura, K Ballman, C Vathanaprida, PA Kiener, TR Martin |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
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IL-12 attenuates bleomycin-induced pulmonary fibrosis
MP Keane, JA Belperio, MD Burdick, RM Strieter |
American journal of physiology. Lung cellular and molecular physiology | 2001 |
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Type II Pneumocyte–CD8 + T-Cell Interactions: Relationship between Target Cell Cytotoxicity and Activation
MQ Zhao, MK Amir, WR Rice, RI Enelow |
American journal of respiratory cell and molecular biology | 2001 |
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Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
S Natori, C Rust, LM Stadheim, A Srinivasan, LJ Burgart, GJ Gores |
Journal of Hepatology | 2001 |
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Perforin and Fas in murine gammaherpesvirus-specific CD8+ T cell control and morbidity
GT Belz, RC Cardin, JW Brooks, PC Doherty, JP Christensen, DJ Topham |
Journal of General Virology | 2001 |
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Bleomycin-Induced Pneumonitis
S Sleijfer |
Chest | 2001 |
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Gene Therapy for Acute and Acquired Diseases
P Factor |
2001 | |
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Fas/Fas Ligand System Mediates Epithelial Injury, but Not Pulmonary Host Defenses, in Response to Inhaled Bacteria
EI Tuomanen, G Matute-Bello, CW Frevert, WC Liles, M Nakamura, JT Ruzinski, K Ballman, VA Wong, C Vathanaprida, TR Martin |
Infection and immunity | 2001 |
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Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac
KM Giles, K Ross, AG Rossi, NA Hotchin, C Haslett, I Dransfield |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
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Impairment of Bleomycin-Induced Lung Fibrosis in CD28-Deficient Mice
T Okazaki, A Nakao, H Nakano, F Takahashi, K Takahashi, O Shimozato, K Takeda, H Yagita, K Okumura |
Journal of immunology (Baltimore, Md. : 1950) | 2001 |
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Role of Apoptosis in Pseudomonas aeruginosa Pneumonia
RS Hotchkiss, WM Dunne, PE Swanson, CG Davis, KW Tinsley, KC Chang, TG Buchman, IE Karl |
Science | 2001 |
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Alveolar epithelial type II cell: defender of the alveolus revisited.
Fehrenbach H |
Respiratory Research | 2001 |
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Lung fibrosis
C Fonseca, D Abraham, CM Black |
Springer Seminars in Immunopathology | 2000 |
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Induction of apoptosis during development of hypertensive nephrosclerosis1
WZ Ying, PX Wang, PW Sanders |
Kidney International | 2000 |
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Circulating levels of soluble Fas ligand and soluble Fas in patients with chronic obstructive pulmonary disease
N Takabatake, H Nakamura, S Inoue, K Terashita, H Yuki, S Kato, S Yasumura, H Tomoike |
Respiratory Medicine | 2000 |
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Over-expression of the decoy receptor 3 (DcR3) gene in peripheral blood mononuclear cells (PBMC) derived from silicosis patients
T Otsuki, A Tomokuni, H Sakaguchi, T Aikoh, T Matsuki, Y Isozaki, F Hyodoh, H Ueki, M Kusaka, S Kita, A Ueki |
Clinical & Experimental Immunology | 2000 |
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MECHANISMS OF REPAIR AND REMODELING FOLLOWING ACUTE LUNG INJURY
DH Ingbar |
Clinics in Chest Medicine | 2000 |
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Signal Transduction Pathways in Hyperoxia-Induced Lung Cell Death
LL Mantell, PJ Lee |
Molecular Genetics and Metabolism | 2000 |
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Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis
H Zhang, J Cook, J Nickel, R Yu, K Stecker, K Myers, NM Dean |
Nature Biotechnology | 2000 |
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Th2-type cytokines and the Fas way to pulmonary fibrosis: Comment on the article by Atamas et al
F Spinozzi, E Agea, A Russano, O Bistoni, G Bassotti, FM DeBenedictis, A Bertotto |
Arthritis & Rheumatism | 2000 |
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Measurement of soluble Fas antigen and ligand in circulating serum and intra-abdominal or cerebrospinal fluid during gastrointestinal or cerebrovascular surgery
H Iwama, M Kato, S Ohmori, K Akimaru, K Tsutsumi, J Tohma, N Nakamura |
Journal of Critical Care | 2000 |
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Pulmonary Fibrosis: Pathways Are Slowly Coming into Light
JA Cooper |
American journal of respiratory cell and molecular biology | 2000 |
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The Fas/Fas-Ligand System Is Not Required for Bleomycin-induced Pulmonary Fibrosis in Mice
K Aoshiba, S Yasui, J Tamaoki, A Nagai |
American journal of respiratory and critical care medicine | 2000 |
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Mesenchymal Regulation of Alveolar Repair in Pulmonary Fibrosis
KC Fang |
American journal of respiratory cell and molecular biology | 2000 |
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Signal Transduction Pathways of Apoptosis and Inflammation Induced by the Tumor Necrosis Factor Receptor Family
K Kuwano, N Hara |
American journal of respiratory cell and molecular biology | 2000 |
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Bleomycin-Mediated Pulmonary Toxicity: Evidence for a p53-Mediated Response
A Mishra, NA Doyle, WJ Martin |
American journal of respiratory cell and molecular biology | 2000 |
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Mechanisms of COPD
R M. |
Chest | 2000 |
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Apoptosis in lung pathophysiology
A Fine, Y Janssen-Heininger, RP Soultanakis, SG Swisher, BD Uhal |
American journal of physiology. Lung cellular and molecular physiology | 2000 |
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C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis
J Hughes, M Nangaku, CE Alpers, SJ Shankland, WG Couser, RJ Johnson |
American journal of physiology. Renal physiology | 2000 |
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The Inhibition of Apoptosis in Myositis and in Normal Muscle Cells
K Nagaraju, L Casciola-Rosen, A Rosen, C Thompson, L Loeffler, T Parker, C Danning, PJ Rochon, J Gillespie, P Plotz |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
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Pivotal Role of CCR1-Positive Leukocytes in Bleomycin- Induced Lung Fibrosis in Mice
A Tokuda, M Itakura, N Onai, H Kimura, T Kuriyama, K Matsushima |
Journal of immunology (Baltimore, Md. : 1950) | 2000 |
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Weak anti-HIV CD8+ T-cell effector activity in HIV primary infection
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Journal of Clinical Investigation | 1999 |
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A Fas pathway to pulmonary fibrosis
HA Chapman |
Journal of Clinical Investigation | 1999 |
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Apoptosis in Human Disease: A New Skin for the Old Ceremony?
B Fadeel, S Orrenius, B Zhivotovsky |
Biochemical and Biophysical Research Communications | 1999 |
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Sepsis and Organ Dysfunction
AE Baue, G Berlot, A Gullo, JL Vincent |
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