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Citations to this article

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
My G. Mahoney, … , Masayuki Amagai, John R. Stanley
My G. Mahoney, … , Masayuki Amagai, John R. Stanley
Published February 15, 1999
Citation Information: J Clin Invest. 1999;103(4):461-468. https://doi.org/10.1172/JCI5252.
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Article Article has an altmetric score of 19

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris

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Abstract

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV blisters are due to loss of keratinocyte cell–cell adhesion in the superficial and deep epidermis, respectively. PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodies bind Dsg3 or both Dsg3 and Dsg1. In this study, we test the hypothesis that coexpression of Dsg1 and Dsg3 in keratinocytes protects against pathology due to antibody-induced dysfunction of either one alone. Using passive transfer of pemphigus IgG to normal and DSG3null neonatal mice, we show that in the areas of epidermis and mucous membrane that coexpress Dsg1 and Dsg3, antibodies against either desmoglein alone do not cause spontaneous blisters, but antibodies against both do. In areas (such as superficial epidermis of normal mice) where Dsg1 without Dsg3 is expressed, anti-Dsg1 antibodies alone can cause blisters. Thus, the anti-desmoglein antibody profiles in pemphigus sera and the normal tissue distributions of Dsg1 and Dsg3 determine the sites of blister formation. These studies suggest that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and demonstrate that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.

Authors

My G. Mahoney, Zhihong Wang, Kyle Rothenberger, Peter J. Koch, Masayuki Amagai, John R. Stanley

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1991 Total
Citations: 6 6 10 12 5 11 21 12 4 17 13 17 15 16 20 12 13 18 28 15 11 13 11 24 16 4 1 351
Citation information
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Citations to this article in year 2009 (12)

Title and authors Publication Year
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
The desmosome
E Delva, DK Tucker, AP Kowalczyk
Cold Spring Harbor perspectives in biology 2009
Diagnostic significance of immunofluorescent tests in dermatology
L Medenica, D Skiljevic
Medicinski pregled 2009
The molecular logic of pemphigus and impetigo: the desmoglein story
M Amagai
Veterinary Dermatology 2009
Autoantibodies against desmocollins in European patients with pemphigus
R Müller, B Heber, T Hashimoto, G Messer, R Müllegger, A Niedermeier, M Hertl
Clinical and Experimental Dermatology 2009
Pemphiguserkrankungen bei Kindern und Jugendlichen
M Meurer
Der Hautarzt 2009
Who Will Develop Pemphigus Foliaceus?
J Tzu, Y Romagosa, RS Kirsner
Journal of Investigative Dermatology 2009
Investigations on the nature and pathogenicity of circulating antikeratinocyte antibodies in dogs with pemphigus foliaceus
T Olivry, SM Dunston, RH Walker, Z Alhaidari, L Messinger, Z Liu
Veterinary Dermatology 2009
Anin vitromodel of human oral explants to study early effects of radiation mucositis
E Donetti, M Bedoni, P Capone, A Gualerzi, G Tartaglia, C Sforza
European Journal of Oral Sciences 2009
Dermatoses bolhosas auto-imunes
PR Cunha, SR Barraviera
Anais Brasileiros de Dermatologia 2009
Fortschritte der praktischen Dermatologie und Venerologie
T Ruzicka, H Wolff, P Thomas, J Prinz
2009
Braun-Falco’s Dermatology
WH Burgdorf, G Plewig, HH Wolff, M Landthaler, O Braun-Falco
2009

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