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Citations to this article

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
My G. Mahoney, … , Masayuki Amagai, John R. Stanley
My G. Mahoney, … , Masayuki Amagai, John R. Stanley
Published February 15, 1999
Citation Information: J Clin Invest. 1999;103(4):461-468. https://doi.org/10.1172/JCI5252.
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Article Article has an altmetric score of 19

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris

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Abstract

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV blisters are due to loss of keratinocyte cell–cell adhesion in the superficial and deep epidermis, respectively. PF autoantibodies are directed against desmoglein (Dsg) 1; PV autoantibodies bind Dsg3 or both Dsg3 and Dsg1. In this study, we test the hypothesis that coexpression of Dsg1 and Dsg3 in keratinocytes protects against pathology due to antibody-induced dysfunction of either one alone. Using passive transfer of pemphigus IgG to normal and DSG3null neonatal mice, we show that in the areas of epidermis and mucous membrane that coexpress Dsg1 and Dsg3, antibodies against either desmoglein alone do not cause spontaneous blisters, but antibodies against both do. In areas (such as superficial epidermis of normal mice) where Dsg1 without Dsg3 is expressed, anti-Dsg1 antibodies alone can cause blisters. Thus, the anti-desmoglein antibody profiles in pemphigus sera and the normal tissue distributions of Dsg1 and Dsg3 determine the sites of blister formation. These studies suggest that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and demonstrate that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.

Authors

My G. Mahoney, Zhihong Wang, Kyle Rothenberger, Peter J. Koch, Masayuki Amagai, John R. Stanley

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1991 Total
Citations: 6 6 10 12 5 11 21 12 4 17 13 17 15 16 20 12 13 18 28 15 11 13 11 24 16 4 1 351
Citation information
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Citations to this article in year 2007 (18)

Title and authors Publication Year
Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3
V Spindler, D Drenckhahn, D Zillikens, J Waschke
The American Journal of Pathology 2007
Pemphigus vulgaris immunoglobulin G can recognize a 130 000 MW antigen other than desmoglein 3 on peripheral blood mononuclear cell surface
N Cirillo, F Gombos, A Lanza
Immunology 2007
A Perspective of Pemphigus from Bedside and Laboratory-Bench
Y Kitajima, Y Aoyama
Clinical Reviews in Allergy & Immunology 2007
What’s new in blistering disorders?
P Chaudhari, MP Marinkovich
Current Allergy and Asthma Reports 2007
Imaging and Force Spectroscopy on Desmoglein 1 Using Atomic Force Microscopy Reveal Multivalent Ca2+-Dependent, Low-Affinity Trans-Interaction
J Waschke, C Menendez-Castro, P Bruggeman, R Koob, M Amagai, HJ Gruber, D Drenckhahn, W Baumgartner
Journal of Membrane Biology 2007
Mucocutaneous pemphigus vulgaris carrying high-titre antidesmoglein 1 antibodies with skin lesions resembling pemphigus erythematosus
N Cirillo, R Santoro, M Lanza, P Annese, F Gombos, A Lanza
Clinical and Experimental Dermatology 2007
IgG against extracellular subdomains of desmoglein 3 relates to clinical phenotype of pemphigus vulgaris
R Müller, V Svoboda, E Wenzel, HH Müller, M Hertl
Experimental Dermatology 2007
Beyond steric hindrance: The role of adhesion signaling pathways in the pathogenesis of pemphigus
P Sharma, X Mao, AS Payne
Journal of Dermatological Science 2007
If pemphigus vulgaris IgG are the cause of acantholysis, new IgG-independent mechanisms are the concause
N Cirillo, M Lanza, F Femiano, GM Gaeta, AD Rosa, F Gombos, A Lanza
Journal of Cellular Physiology 2007
Intraperitoneal injection of pemphigus vulgaris-IgG into mouse depletes epidermal keratinocytes of desmoglein 3 associated with generation of acantholysis
E Shu, Y Yamamoto, Y Aoyama, Y Kitajima
Archives of Dermatological Research 2007
No activation of urokinase plasminogen activator by anti-desmoglein 3 monoclonal IgG antibodies in cultured human keratinocytes
Y Yamamoto, Y Aoyama, E Shu, K Tsunoda, M Amagai, Y Kitajima
Journal of Dermatological Science 2007
Pemphigus vulgaris presenting in a radiation portal
AC Robbins, Z Lazarova, MM Janson, JA Fairley
Journal of the American Academy of Dermatology 2007
Caspase-dependent cleavage of desmoglein 1 depends on the apoptotic stimulus
A Lanza, N Cirillo
British Journal of Dermatology 2007
Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes
N Cirillo, F Femiano, F Gombos, A Lanza
Oral Diseases 2007
IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus
K Nishifuji, T Olivry, K Ishii, T Iwasaki, M Amagai
Veterinary Immunology and Immunopathology 2007
Using Desmoglein 1 and 3 Enzyme-linked Immunosorbent Assay as an Adjunct Diagnostic Tool for Pemphigus
CH Huang, CC Chen, CJ Wang, YT Chang, HN Liu
Journal of the Chinese Medical Association 2007
Internalization of Non-Clustered Desmoglein 1 without Depletion of Desmoglein 1 from Adhesion Complexes in An Experimental Model of the Autoimmune Disease Pemphigus Foliaceus
A Lanza, AD Rosa, F Femiano, P Annese, E Ruocco, F Gombos, M Lanza, N Cirillo
International journal of immunopathology and pharmacology 2007
Anti-desmoglein 3 (Dsg3) Monoclonal Antibodies Deplete Desmosomes of Dsg3 and Differ in Their Dsg3-depleting Activities Related to Pathogenicity
Y Yamamoto, Y Aoyama, E Shu, K Tsunoda, M Amagai, Y Kitajima
The Journal of biological chemistry 2007

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