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Citations to this article

Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation
Gesine Hansen, … , Rosemarie H. DeKruyff, Dale T. Umetsu
Gesine Hansen, … , Rosemarie H. DeKruyff, Dale T. Umetsu
Published January 15, 1999
Citation Information: J Clin Invest. 1999;103(2):175-183. https://doi.org/10.1172/JCI5155.
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Allergen-specific Th1 cells fail to counterbalance Th2 cell–induced airway hyperreactivity but cause severe airway inflammation

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Abstract

Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5. Because Th1 cells antagonize Th2 cell functions, it has been proposed that immune deviation toward Th1 can protect against asthma and allergies. Using an adoptive transfer system, we assessed the roles of Th1, Th2, and Th0 cells in a mouse model of asthma and examined the capacity of Th1 cells to counterbalance the proasthmatic effects of Th2 cells. Th1, Th2, and Th0 lines were generated from ovalbumin (OVA)-specific T-cell receptor (TCR) transgenic mice and transferred into lymphocyte-deficient, OVA-treated severe combined immunodeficiency (SCID) mice. OVA-specific Th2 and Th0 cells induced significant airway hyperreactivity and inflammation. Surprisingly, Th1 cells did not attenuate Th2 cell–induced airway hyperreactivity and inflammation in either SCID mice or in OVA-immunized immunocompetent BALB/c mice, but rather caused severe airway inflammation. These results indicate that antigen-specific Th1 cells may not protect or prevent Th2-mediated allergic disease, but rather may cause acute lung pathology. These findings have significant implications with regard to current therapeutic goals in asthma and allergy and suggest that conversion of Th2-dominated allergic inflammatory responses into Th1-dominated responses may lead to further problems.

Authors

Gesine Hansen, Gerald Berry, Rosemarie H. DeKruyff, Dale T. Umetsu

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Citations to this article in year 2016 (12)

Title and authors Publication Year
Role of Anti-inflammatory Cytokines IL-35 and IL-37 in Asthma
D Hu
Inflammation 2016
IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity
Y Ohne, JS Silver, LA Thompson-Snipes, MA Collet, JP Blanck, BL Cantarel, AM Copenhaver, AA Humbles, YJ Liu
Nature Immunology 2016
Mucosal expression of DEC-205 targeted allergen alleviates an asthmatic phenotype in mice
A Maaske, FC Devos, T Niezold, D Lapuente, A Tannapfel, JA Vanoirbeek, K Überla, M Peters, M Tenbusch
Journal of Controlled Release 2016
Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responses
NM Troy, EM Hollams, PG Holt, A Bosco
BMC Medical Genomics 2016
Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
H Hosokawa, T Tanaka, Y Endo, M Kato, K Shinoda, A Suzuki, S Motohashi, M Matsumoto, KI Nakayama, T Nakayama
Nature Communications 2016
Role of neutralizing anti-murine interleukin-17A monoclonal antibody on chronic ozone-induced airway inflammation in mice
M Zhang, X Fei, G Zhang, P Zhang, F Li, W Bao, Y Zhang, X Zhou
Biomedicine & Pharmacotherapy 2016
Critical role of CD44 in antigen-induced Th2- but not Th17-madiated murine airway inflammation
T Nishimura, S Katoh, A Mori, T Ohtomo, M Saeki, T Hiroi, O Kaminuma
Allergology International 2016
Selected CC and CXC chemokines in children with atopic asthma
E Machura, M Szczepanska, B Mazur, E Chrobak, K Ziora, D Ziora, A Kasperska-Zajac
POSTEP DERM ALERGOL 2016
iNKT Cells Are Responsible for the Apoptotic Reduction of Basophils That Mediate Th2 Immune Responses Elicited by Papain in Mice Following γPGA Stimulation
HJ Park, SW Lee, SH Park, S Hong, M Leite-de-Moraes
PloS one 2016
Secondary allergic T cell responses are regulated by dendritic cell-derived thrombospondin-1 in the setting of allergic eye disease
RE Smith, NJ Reyes, P Khandelwal, SL Schlereth, HS Lee, S Masli, DR Saban
Journal of leukocyte biology 2016
Blomia tropicalis –Specific TCR Transgenic Th2 Cells Induce Inducible BALT and Severe Asthma in Mice by an IL-4/IL-13–Dependent Mechanism
YL Chua, KH Liong, CH Huang, HS Wong, Q Zhou, SS Ler, Y Tang, CP Low, HY Koh, IC Kuo, Y Zhang, WS Wong, HY Peh, HY Lim, MQ Ge, A Haczku, V Angeli, PA MacAry, KY Chua, DM Kemeny
Journal of immunology (Baltimore, Md. : 1950) 2016
An early innate response underlies severe influenza-induced exacerbations of asthma in a novel steroid-insensitive and anti-IL-5-responsive mouse model
L Ravanetti, A Dijkhuis, YS Pineros, SM Bal, BS Dierdorp, T Dekker, A Logiantara, IM Adcock, NL Rao, L Boon, G Villetti, PJ Sterk, F Facchinetti, R Lutter
Allergy 2016

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